Adapalene and acetyl hexapeptide-3
Keep them apart
Use them at different times of day by applying acetyl hexapeptide-3 in the morning and adapalene at night, because strong retinoids should not be mixed with peptides in the same routine. Using them together can overwhelm your skin and cause extra redness or irritation, but you can easily avoid this by leaving more time between the two or switching to a gentler formula.
Adapalene products
- Differin Gel
- Galderma Epiduo Gel
- La Roche-Posay Effaclar Adapalene Gel 0.1% Acne Treatment
Acetyl hexapeptide-3 products
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The Ordinary
Multi-Peptide + Copper Peptides 1% Serum
拢28.90
-
The Ordinary
Multi-Peptide + HA Serum
拢12.72
-
Medik8
Liquid Peptides
拢51.15
-
La Mer
The Treatment Lotion
拢209.56
-
Rhode
Peptide Glazing Fluid
拢35.00
-
The Ordinary
Argireline Solution 10%
拢7.36
-
Good Molecules
Super Peptide Serum
拢17.00
-
Clinique
Smart Clinical Repair Wrinkle Correcting Serum
拢46.87
-
La Mer
The Renewal Oil
拢175.50
-
Est茅e Lauder
Micro Essence Treatment Lotion
拢42.00
- The INKEY List Collagen Peptide Serum
-
La Mer
The Eye Concentrate
拢199.00
Questions and answers
Can you use adapalene and acetyl hexapeptide-3 together?
Keep adapalene and acetyl hexapeptide-3 apart because combining them may increase skin irritation. Instead, alternate their usage by applying adapalene in the PM and peptides in the AM.
Which goes first, adapalene or acetyl hexapeptide-3?
Keep adapalene and acetyl hexapeptide-3 apart because combined stimulation may increase irritation. Alternate usage by applying your retinoid in the PM and peptides in the AM.
Are adapalene and acetyl hexapeptide-3 good for sensitive skin?
Keep adapalene and acetyl hexapeptide-3 apart because combined stimulation may increase irritation, making them unsuitable to use together on sensitive skin. Instead, alternate usage by applying the retinoid in the PM and peptides in the AM.
Research on adapalene and acetyl hexapeptide-3
Behind this pairing advice
Lovi checks every pairing with brand-independent rules our dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update.
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Dr. Sof铆a Perea P茅rez, MD, MSc
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Medical Board
Specialist dermatologist, MBBS, MD, IFAAD
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Cosmetic chemist, SCS, IFSCC member
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Medical Board, Medical Advisor
Dermatology MD
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Elina Nazarenko, MD
Medical Board
Dermatology and diagnostic consultant
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Victoria Derkova, MS
Medical Board
Cosmetic chemist, cosmetic development technologist
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