Adapalene and palmitoyl tripeptide-1
Keep them apart
Use them at different times of day by applying palmitoyl tripeptide-1 in the morning and adapalene at night. Using both together can cause extra skin irritation because they are both very active. You can prevent this by switching to a lower strength or giving your skin more time between them.
Adapalene products
- Differin Gel
- Galderma Epiduo Gel
- La Roche-Posay Effaclar Adapalene Gel 0.1% Acne Treatment
Palmitoyl tripeptide-1 products
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The Ordinary
Multi-Peptide + Copper Peptides 1% Serum
拢28.90
-
The Ordinary
Multi-Peptide + HA Serum
拢12.72
-
Medik8
Liquid Peptides
拢51.15
-
Shiseido
Benefiance Wrinkle Smoothing Eye Cream
拢42.45
-
Clinique
Smart Clinical Repair Wrinkle Correcting Serum
拢46.87
- Alastin Skincare Regenerating Skin Nectar
-
The Ordinary
Matrixyl 10% + HA
拢8.32
- ZO Skin Health Daily Power Defense
- The INKEY List Collagen Peptide Serum
- Alastin Ultra Nourishing Moisturizer
-
DRMTLGY
Needle-less Serum
拢51.98
- Valmont Prime Renewing Pack
Questions and answers
Can you use adapalene and palmitoyl tripeptide-1 together?
Keep adapalene and palmitoyl tripeptide-1 apart because combined stimulation may increase irritation. Alternate usage by applying your retinoid in the PM and peptides in the AM.
Which goes first, adapalene or palmitoyl tripeptide-1?
Keep adapalene and palmitoyl tripeptide-1 apart in your routine because combining them may increase irritation. Use adapalene in the evening and palmitoyl tripeptide-1 in the morning.
Are adapalene and palmitoyl tripeptide-1 good for sensitive skin?
Keep adapalene and palmitoyl tripeptide-1 apart in your routine, as combining strong retinoids like adapalene with peptides may increase irritation on sensitive skin. Instead, alternate their usage by applying your retinoid in the PM and peptides in the AM.
Research on adapalene and palmitoyl tripeptide-1
Behind this pairing advice
Lovi checks every pairing with brand-independent rules our dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update.
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Co-founder, Medical Director
Cosmetic chemist, cosmetologist, aesthetic products developer
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Co-founder, CEO and CTO
PhD in computer science, 3x US patent holder, ex-Google, ex-Yandex
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Dr. Sof铆a Perea P茅rez, MD, MSc
Medical Board
Aesthetic medicine practitioner, MSc in Longevity and Anti-Aging Medicine
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Medical Board
Specialist dermatologist, MBBS, MD, IFAAD
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Medical Board
Cosmetic chemist, SCS, IFSCC member
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Medical Board, Medical Advisor
Dermatology MD
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Elina Nazarenko, MD
Medical Board
Dermatology and diagnostic consultant
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Victoria Derkova, MS
Medical Board
Cosmetic chemist, cosmetic development technologist
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