SKIN1004 Probio-Cica Essence Toner for mature skin

How to apply

Questions and answers

What the research says

• Topical application of 1.0% Lactobacillus ferment from jojoba cake significantly increased skin collagen fluorescence compared to baseline and placebo cream over 56 days in 46 individuals.

  International Journal of Cosmetic Science, 2026

• A new topical panthenol-containing emollient significantly improved transepidermal water loss reduction, stratum corneum hydration, and intercellular lipid lamellae length compared with control in healthy subjects without negatively impacting bacterial viability.

  The Journal of Dermatological Treatment, 2017

• Topical hyaluronic acid filler serum combined with Botulinum toxin type A lengthened the duration of the toxin's effect in reducing wrinkles compared to Botulinum toxin type A alone.

  Dermatologic Therapy, 2022

• Topical dexpanthenol acts as a moisturizer, improves stratum corneum hydration, accelerates wound healing and epidermal regeneration, reduces erythema, and improves symptoms of skin irritation compared to vehicle or no pretreatment.

  American Journal of Clinical Dermatology, 2002

• A topical formulation containing panthenol, niacinamide, and dipotassium glycyrrhizate increased skin hydration by 74.1% and reduced transepidermal water loss by 13.5% at 28 days compared to baseline and untreated control in 35 individuals with xerosis.

  Journal of Cosmetic Dermatology, 2026

• Topical application of 0.05% w/w ECa 233 gel reduced erythema index by 0.03 U and improved early crusting and general wound appearance compared to placebo in thirty individuals undergoing facial laser resurfacing.

  Journal of Alternative and Complementary Medicine, 2020

• A single application of a moisturizing fluid containing hyaluronic acid 1%, glycerin 5%, and Centella asiatica stem cells extract significantly increased skin hydration by 29% and reduced transepidermal water loss at 24 hours compared to baseline and an untreated control site in twenty healthy women.

  Clinical, Cosmetic and Investigational Dermatology, 2017

• Moisturizer containing 5% panthenol, madecassoside, and copper-zinc-manganese decreased adverse reactions and downtime after ablative fractional carbon dioxide laser resurfacing with comparable efficacy to 0.02% triamcinolone acetonide cream in 20 subjects.

  Journal of Cosmetic Dermatology, 2019

• Topical application of 0.1% hyaluronic acid formulations of different molecular weights led to significant improvements in skin hydration and elasticity, with low-molecular-weight formulations also significantly reducing wrinkle depth in seventy-six female subjects compared to a vehicle control.

  Journal of Drugs in Dermatology, 2011

• Topical application of hyaluronic acid in conjunction with free gingival graft significantly reduced donor site postoperative pain until day 7 compared to normal saline, with no significant differences in graft dimensions or patient satisfaction.

  Clinical Oral Investigations, 2022

• Treatment with a hyaluronic acid-containing mouth rinse or topical gel led to significant lesion reduction, pain relief, and normalization of lesion color in adult patients with minor recurrent aphthous stomatitis, with the gel formulation showing an earlier healing onset at 3 days.

  BMC Oral Health, 2019

• Topical dexpanthenol formulated in lipophilic vehicles improved stratum corneum hydration and reduced transepidermal water loss compared to vehicle control in humans.

  Arzneimittel-Forschung, 2000

• Hyaluronic acid, hyaluronic acid plus dexpanthenol, and isotonic saline nasal sprays all significantly improved dry nose symptoms over four weeks in 240 patients, with hyaluronic acid plus dexpanthenol providing superior nasal moisturisation compared to the other two.

  Auris, Nasus, Larynx, 2020

• A combination serum containing galactomyces ferment filtrate, dexpanthenol, and Centella asiatica effectively treated post-acne hyperpigmentation in subjects with colored skin by significantly increasing lightness scores in Fitzpatrick skin type V and reducing the melanin index in Fitzpatrick skin type IV compared to placebo.

  Skinmed, 2021

Ingredients

Water, Butylene Glycol, Glycerin, Propanediol, 1,2-Hexanediol, Centella Asiatica Extract, Polyglyceryl-10 Laurate, Acrylates C10-30 Alkyl Acrylate Crosspolymer, Panthenol, Trehalose, Ethylhexylglycerin, Xanthan Gum, Sodium Citrate, Tromethamine, Dipotassium Glycyrrhizate, Caprylic Capric Triglyceride, Citric Acid, Sodium Phytate, Hydrogenated Lecithin, Polyglyceryl-10 Myristate, Ceramide Np, Sucrose Distearate, Lactobacillus Ferment, Sodium Hyaluronate Crosspolymer, Asiaticoside, Madecassic Acid, Hydrolyzed Glycosaminoglycans, Asiatic Acid, Phytosterols, Lauric Acid, Sodium Hyaluronate, Betaine, Hydroxystearic Acid, Benzyl Glycol, Hydrolyzed Hyaluronic Acid, Macadamia Ternifolia Seed Oil, Raspberry Ketone, Phytosphingosine

Behind this fit score

Lovi calculates every fit score from the full ingredient list with brand-independent rules our dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update.