Benefits of topical hyaluronic acid for skin quality and signs of skin aging: From literature review to clinical evidence
Sodium hyaluronate, Hyaluronic acid 路 Dermatologic Therapy, 2022Topical use of dexpanthenol in skin disorders
Panthenol 路 American Journal of Clinical Dermatology, 2002Bifidobacterium longum lysate, a new ingredient for reactive skin
1 路 Experimental Dermatology, 2010Final report on the safety assessment of BHT(1)
Butylated hydroxytoluene 路 International Journal of Toxicology, 2002The efficacy of 5% topical tea tree oil gel in mild to moderate acne vulgaris: a randomized, double-blind placebo-controlled study
Melaleuca alternifolia oil leaf 路 Indian Journal of Dermatology, Venereology and Leprology, 2007Prospective, randomized, double-blind assessment of topical bakuchiol and retinol for facial photoageing
Bakuchiol 路 The British Journal of Dermatology, 2019Moisturizing and Antiinflammatory Properties of Cosmetic Formulations Containing Centella asiatica Extract
Centella asiatica extract, Madecassoside, Madecassic acid, Centella asiatica 路 Indian Journal of Pharmaceutical Sciences, 2016Skin penetration and stabilization of formulations containing microfine titanium dioxide as physical UV filter
Titanium dioxide 路 International Journal of Cosmetic Science, 2000Topical Application of Centella asiatica in Wound Healing: Recent Insights into Mechanisms and Clinical Efficacy
Centella asiatica extract 路 Pharmaceutics, 2024Treatment of acne with a combination of propolis, tea tree oil, and Aloe vera compared to erythromycin cream: two double-blind investigations
Aloe barbadensis leaf extract, Melaleuca alternifolia oil leaf 路 Clinical Pharmacology, 2018Clinical Assessment of New Topical Cream Containing Two Essential Oils Combined with Tretinoin in the Treatment of Acne
Tretinoin 路 Clinical, Cosmetic and Investigational Dermatology, 2020Ceramide 1 and ceramide 3 act synergistically on skin hydration and the transepidermal water loss of sodium lauryl sulfate-irritated skin
Ceramide np 路 International Journal of Dermatology, 2008Comparison of clinical and histological effects between lactobacillus-fermented Chamaecyparis obtusa and tea tree oil for the treatment of acne: an eight-week double-blind randomized controlled split-face study
Melaleuca alternifolia oil leaf 路 Dermatology, 2014The 24-hour skin hydration and barrier function effects of a hyaluronic 1%, glycerin 5%, and Centella asiatica stem cells extract moisturizing fluid: an intra-subject, randomized, assessor-blinded study
Glycerin, Madecassoside, Madecassic acid 路 Clinical, Cosmetic and Investigational Dermatology, 2017Randomized controlled study for the anti-aging effect of human adipocyte-derived mesenchymal stem cell media combined with niacinamide after laser therapy
Niacinamide 路 Journal of Cosmetic Dermatology, 2021The Effects of a Standardized Extract of Centella asiatica on Postlaser Resurfacing Wound Healing on the Face: A Split-Face, Double-Blind, Randomized, Placebo-Controlled Trial
Madecassoside, Madecassic acid 路 Journal of Alternative and Complementary Medicine, 2020The human stratum corneum layer: an effective barrier against dermal uptake of different forms of topically applied micronised titanium dioxide
Titanium dioxide 路 Skin Pharmacology and Applied Skin Physiology, 2001The anti-wrinkle efficacy of argireline, a synthetic hexapeptide, in Chinese subjects: a randomized, placebo-controlled study
Acetyl hexapeptide-8 路 American Journal of Clinical Dermatology, 2013Senomorphic activity of a combination of niacinamide and hyaluronic acid: correlation with clinical improvement of skin aging
Niacinamide 路 Scientific Reports, 2024A new topical panthenol-containing emollient: Results from two randomized controlled studies assessing its skin moisturization and barrier restoration potential, and the effect on skin microflora
Panthenol 路 The Journal of Dermatological Treatment, 2017A Double-Blinded, Randomized, Vehicle-Controlled Study of the Efficacy of Moisturizer Containing Licochalcone A, Decanediol, L-Carnitine, and Salicylic Acid for Prevention of Acne Relapse in Asian Population
Salicylic acid 路 BioMed Research International, 2020Adenosine-loaded dissolving microneedle patches to improve skin wrinkles, dermal density, elasticity and hydration
Adenosine 路 International Journal of Cosmetic Science, 2018A topical gel of tea tree oil nanoemulsion containing adapalene versus adapalene marketed gel in patients with acne vulgaris: a randomized clinical trial
Melaleuca alternifolia oil leaf 路 Archives of Dermatological Research, 2022Comparative study of efficacy and safety of 45% mandelic acid versus 30% salicylic acid peels in mild-to-moderate acne vulgaris
Mandelic acid 路 Journal of Cosmetic Dermatology, 2020High molecular compounds (polysaccharides and proanthocyanidins) from Hamamelis virginiana bark: influence on human skin keratinocyte proliferation and differentiation and influence on irritated skin
Witch hazel 路 Phytochemistry, 2001Self-Assembled Cubic Liquid Crystalline Nanoparticles for Transdermal Delivery of Paeonol
Paeonia suffruticosa root extract 路 Medical Science Monitor, 2015Efficacy of a topical gel containing chitosan, chlorhexidine, allantoin and dexpanthenol for pain and inflammation control after third molar surgery: A randomized and placebo-controlled clinical trial
Panthenol, Allantoin 路 Medicina Oral, Patologia Oral Y Cirugia Bucal, 2020The efficacy of glycolic acid, salicylic acid, gluconolactone, and licochalcone A combined with 0.1% adapalene vs adapalene monotherapy in mild-to-moderate acne vulgaris: a double-blinded within-person comparative study
Gluconolactone 路 Clinical, Cosmetic and Investigational Dermatology, 2019Efficacy assessments of tretinoin-loaded nano lipid carriers in acne vulgaris: a double blind, split-face randomized clinical study
Tretinoin 路 Archives of Dermatological Research, 2022Topical tretinoin for treating photoaging: A systematic review of randomized controlled trials
Tretinoin 路 International Journal of Women's Dermatology, 2022Systematic Study of Paeonol/Madecassoside Co-Delivery Nanoemulsion Transdermal Delivery System for Enhancing Barrier Repair and Anti-Inflammatory Efficacy
Centella asiatica extract, Madecassoside, Centella asiatica 路 Molecules, 2023A comparative study of gluconolactone versus benzoyl peroxide in the treatment of acne
Gluconolactone 路 The Australasian Journal of Dermatology, 1992Phyllanthus emblica L. (amla) branch: A safe and effective ingredient against skin aging
1 路 Journal of Traditional and Complementary Medicine, 2021Anti-Wrinkle Efficacy of Cross-Linked Hyaluronic Acid-Based Microneedle Patch with Acetyl Hexapeptide-8 and Epidermal Growth Factor on Korean Skin
Acetyl hexapeptide-8 路 Annals of Dermatology, 2019Efficacy of a multitargeted, salicylic acid-based dermocosmetic cream compared to benzoyl peroxide 5% in Acne vulgaris: Results from a randomized study
Salicylic acid 路 Journal of Cosmetic Dermatology, 2024Biomimetic hyaluronic acid-stabilized zinc oxide nanoparticles in acne treatment: A preclinical and clinical approach
Zinc oxide 路 Journal of Controlled Release, 2025Clay jojoba oil facial mask for lesioned skin and mild acne--results of a prospective, observational pilot study
Jojoba seed oil 路 Forschende Komplementarmedizin, 2012A Lipid Mixture Enriched by Ceramide NP with Fatty Acids of Diverse Chain Lengths Contributes to Restore the Skin Barrier Function Impaired by Topical Corticosteroid
Ceramide np 路 Skin Pharmacology and Physiology, 2022A dermocosmetic containing bakuchiol, Ginkgo biloba extract and mannitol improves the efficacy of adapalene in patients with acne vulgaris: result from a controlled randomized trial
Ginkgo biloba leaf extract, Bakuchiol 路 Clinical, Cosmetic and Investigational Dermatology, 2015The influence of alkane chain length on the skin irritation potential of 1,2-alkanediols
2-hexanediol 路 International Journal of Cosmetic Science, 2011Effects of a lotion containing probiotic ferment lysate as the main functional ingredient on enhancing skin barrier: a randomized, self-control study
1 路 Scientific Reports, 2023A Salicylic Acid-Based Dermocosmetic is Effective as an Adjunct to Benzoyl Peroxide for Mild to Moderate Acne and as Monotherapy in Maintenance Post Benzoyl Peroxide
Salicylic acid 路 Journal of Drugs in Dermatology, 2023Chemical peels for acne vulgaris: a systematic review of randomised controlled trials
Mandelic acid 路 BMJ Open, 2018Nanogel Containing Gamma-Oryzanol-Loaded Nanostructured Lipid Carriers and TiO2/MBBT: A Synergistic Nanotechnological Approach of Potent Natural Antioxidants and Nanosized UV Filters for Skin Protection
Xanthan gum 路 Pharmaceuticals, 2023Botulinum toxin injection as a single or combined treatment with non-cross-linked high molecular weight and low molecular weight hyaluronic acid gel for neck rejuvenation: A randomized clinical trial
Hydrolyzed hyaluronic acid 路 Dermatologic Therapy, 2022Topical application of jojoba (Simmondsia chinensis L.) wax enhances the synthesis of pro-collagen III and hyaluronic acid and reduces inflammation in the ex-vivo human skin organ culture model
Jojoba seed oil 路 Frontiers in Pharmacology, 2024Clinical evaluation of the efficacy of a facial serum containing dioic acid, glycolic acid, salicylic acid, LHA, citric acid, and HEPES in treating post-inflammatory hyperchromia and controlling oily skin in patients with acne vulgaris
Capryloyl salicylic acid 路 Journal of Cosmetic Dermatology, 2021Annurca Apple Oleolite as Functional Ingredient for the Formulation of Cosmetics with Skin-Antiaging Activity
1 路 International Journal of Molecular Sciences, 2024Effect of a botanical cleansing lotion on skin sebum and erythema of the face: A randomized controlled blinded half-side comparison
Willow bark extract 路 Journal of Cosmetic Dermatology, 2019Clinical tolerance and efficacy of capryloyl salicylic acid peel compared to a glycolic acid peel in subjects with fine lines/wrinkles and hyperpigmented skin
Capryloyl salicylic acid 路 Journal of Cosmetic Dermatology, 2008Synergetic Effects of Aloe Vera Extract with Trimethylglycine for Targeted Aquaporin 3 Regulation and Long-Term Skin Hydration
Betaine 路 Molecules, 2024Two-phase delivery using a horse oil and adenosine-loaded dissolving microneedle patch for skin barrier restoration, moisturization, and wrinkle improvement
Adenosine 路 Journal of Cosmetic Dermatology, 2019Clinical Development and Evaluation of a Multi-Component Dissolving Microneedle Patch for Skin Pigmentation Disorders
3-o-ethyl ascorbic acid 路 Polymers, 2023Effects of topical copper tripeptide complex on CO2 laser-resurfaced skin
Copper tripeptide-1 路 Archives of Facial Plastic Surgery, 2006Treatment of mild to moderate acne with a fixed combination of hydroxypinacolone retinoate, retinol glycospheres and papain glycospheres
Carica papaya fruit extract 路 Giornale Italiano Di Dermatologia E Venereologia, 2015Randomized prospective study of low-dose isotretinoin alone and combination with salicylic acid and mandelic peel against acne tarda
Mandelic acid 路 Journal of Cosmetic Dermatology, 2022Topical application of highly concentrated water-in-oil emulsions: Physiological skin parameters and skin penetration in vivo - A pilot study
Isopropyl myristate 路 International Journal of Pharmaceutics, 2019Influence of Panax ginseng formulation on skin microbiota: A randomized, split face comparative clinical study
2-hexanediol 路 Journal of Ginseng Research, 2022Starch- and carboxymethyl cellulose-based films as active beauty masks with papain incorporation
Carica papaya fruit extract 路 International Journal of Biological Macromolecules, 2023Topical Zinc Oxide Nanoparticle Formulations for Acne Vulgaris: A Systematic Review of Pre-Clinical and Early-Phase Clinical Evidence
Zinc oxide 路 Biomedicines, 2025Efficacy and Tolerability of Stable Hybrid Cooperative Complexes of High- and Low-Molecular Weight Hyaluronic Acid in Asian Patients: An Open-Label Study
Hydrolyzed hyaluronic acid 路 Aesthetic Plastic Surgery, 2026Evaluation of the Efficacy and Safety of a Panthenol-Enriched Mask for Skin Barrier Recovery After Facial Laser Treatment: Results of a Double-Blind Randomized Controlled Study
Panthenol 路 Journal of Cosmetic Dermatology, 2025Safety of a preservative system containing 1,2-hexanediol and caprylyl glycol
2-hexanediol 路 Cutaneous and Ocular Toxicology, 2009Antioxidant and membrane-protective effects of the 3-O-ethyl ascorbic acid-cannabigerol system on UVB-irradiated human keratinocytes
3-o-ethyl ascorbic acid 路 Free Radical Biology & Medicine, 2025Moisturizing effect of alcohol-based hand rub containing okra polysaccharide
Hibiscus esculentus fruit extract 路 International Journal of Cosmetic Science, 2012The anti wrinkle efficacy of synthetic hexapeptide (Argireline) in Chinese Subjects
Acetyl hexapeptide-8 路 Journal of Cosmetic and Laser Therapy, 2013Translational Evaluation of a Disodium Adenosine Monophosphate (AMP2Na)-Based Topical Formulation for Physiology-Aligned Skin Rejuvenation: Integrated In Vitro, Ex Vivo, and Clinical Evidence
Adenosine 路 International Journal of Molecular Sciences, 2026Protective effects of Paeonia suffruticosa callus extract in skin through anti-inflammation and repair UVB-induced damage
Paeonia suffruticosa root extract 路 International Journal of Cosmetic Science, 2025Thermostable hyaluronic acid-based dissolving microneedles with high-loading capacity: design, optimization, and transdermal delivery of anti-aging ingredients
3-o-ethyl ascorbic acid 路 International Journal of Biological Macromolecules, 2026Liposomal formulation of a vitamin C derivative: a promising strategy to increase skin permeability
3-o-ethyl ascorbic acid 路 Journal of Liposome Research, 2025Poly-纬-Glutamic Acid from a Novel Bacillus subtilis Strain: Strengthening the Skin Barrier and Improving Moisture Retention in Keratinocytes and a Reconstructed Skin Model
Polyglutamic acid 路 International Journal of Molecular Sciences, 2025Functional properties and skin care effects of sodium trehalose sulfate
Trehalose 路 Skin Research and Technology, 2024Effects of a Postbiotic Saccharomyces and Lactobacillus Ferment Complex on the Scalp Microbiome of Chinese Women with Sensitive Scalp Syndrome
Lactobacillus ferment 路 Clinical, Cosmetic and Investigational Dermatology, 2023Comparison of clindamycin 1% and benzoyl peroxide 5% gel to a novel composition containing salicylic acid, capryloyl salicylic acid, HEPES, glycolic acid, citric acid, and dioic acid in the treatment of acne vulgaris
Capryloyl salicylic acid 路 Journal of Drugs in Dermatology, 2013Split-face evaluation: Gluconolactone plus oxybrasion versus gluconolactone plus microneedling. The effects on skin parameters
Gluconolactone 路 Skin Research and Technology, 2023Efficacy of a Topical Formulation on Skin Hydration and Barrier Function in Individuals With Xerosis: A 28-Day Randomized, Split-Leg, Untreated-Controlled Trial
Dipotassium glycyrrhizate 路 Journal of Cosmetic Dermatology, 2026Prospective, Randomized, Double-Blind Assessment of Supramolecular Bakuchiol and Terminalia Chebula Extract for Facial Photoaging in Chinese Sensitive Skin Population
Bakuchiol 路 Health Science Reports, 2025Simmondsia chinensis (jojoba) cake fermentation: A new, sustainable technology for advanced skin and scalp care ingredients
Lactobacillus ferment 路 International Journal of Cosmetic Science, 2026
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