Avène Cleanance Comedomed for dry skin
Salicylic Acid
Glycolic Acid
Zinc Gluconate
Silybum Marianum Fruit Extract
Pumpkin Seed OilCaution
- CautionDry Skin Fit
- HighEffectiveness
- ConcerningSafety
A poor match for dry skin; the serums alongside fit it better.
This fit is calculated for the concerns frequently associated with dry skin: flakiness, tightness, dehydration, fine lines, and wrinkles. For scores and recommendations based on your full skin profile, including your 12D face scan results and any goals or preferences you have, please use the Lovi app.
Page built Nov 8, 2026How the Fit score works
Lovi Assistant explains
- Offers moderate exfoliation for your dry skin due to the presence of glycolic acid and salicylic acid, which can cause excessive dryness and irritation, rather than providing the emollient and humectant actions needed for dry skin.
- While the product contains soothing ingredients like Dipotassium Glycyrrhizate and Tocopherol, the exfoliating acids are not ideal for your dry skin type.
How to apply
- Apply this serum PM, starting 3×/week and working up to daily use as your skin adjusts.
- Place the serum after cleansing and toner, but right before your moisturizer.
- Gently press 2-3 drops of the serum into your skin and let it absorb for a minute.
- Apply the serum on slightly damp skin to help lock in extra moisture.
- Avoid the eye area and do a patch test before your first use.
People Say
★4.4Overall rating based on 700+ reviewsThis treatment is frequently praised for its effectiveness on oily, blemish-prone, and sensitive skin, particularly in managing blackheads and closed comedones, with many users reporting clearer skin and fewer breakouts. A significant number of users also appreciate its lightweight texture and matte finish. Some users note a strong chemical scent and a drying effect, with a few experiencing irritation or a sticky consistency.
Highlights
Reduces blemishes Mostly Mentioned
- “Significant reduction in blemishes”
- “Keeps breakouts at bay”
- “Effective for whiteheads/blackheads”
Lightweight texture Often Mentioned
- “Ultra-light fluid”
- “Absorbs quickly”
- “Non-greasy finish”
Strong chemical scent Often Mentioned
- “Smells like rubbing alcohol”
- “Overpowering chemical smell”
- “Smell is horrible”
Matte finish Sometimes Noted
- “Leaves skin mattified”
- “Non-oily daily moisturizer”
- “Great for layering”
Prevents recurrence Sometimes Noted
- “Prevents future breakouts”
- “Anti-recurrence action”
- “Keeps pores clean”
Drying effect Sometimes Noted
- “Made my face peel”
- “Dried it out too much”
- “Left my skin really dry”
Can cause irritation Rarely Noted
- “Made skin red and irritated”
- “Not a fit for me”
- “Caused dry patches”
Sticky consistency Rarely Noted
- “It does get quite sticky”
- “Leaves residue”
Sources: lovi.care, avene.co.uk, beautycrew.com.au, dermapproved.com, escentual.com, reddit.com, and more
Questions and answers
Why does Lovi advise caution with Avene Cleanance Comedomed for dry skin?
Lovi advises caution because this treatment offers moderate exfoliation from glycolic acid and salicylic acid, which can cause excessive dryness and irritation on dry skin. Instead of these acids, a product for dry skin needs nourishing and soothing ingredients that provide rich hydration, ceramides, niacinamide, or peptides to support the skin barrier.
Which ingredients make this treatment a poor fit for dry skin?
Glycolic acid and salicylic acid make this treatment a poor fit because they offer moderate exfoliation that may cause excessive dryness and irritation on dry skin. Dry skin needs products with nourishing, barrier-supporting ingredients and moisture-binding agents to provide deep hydration and soothing relief.
What does Salicylic Acid do for dry skin?
Salicylic acid is generally not a good fit for dry skin, as it is meant to clear out pores and remove dead skin rather than hydrate. Because dry skin needs soothing and moisture rather than exfoliation, a product for dry skin needs nourishing ingredients like urea to lock in moisture and keep the skin soft.
What does Glycolic Acid do for dry skin?
Glycolic acid helps smooth and soften dry skin by speeding up the shedding of older surface cells. Because it can also cause the skin to lose more moisture, dry skin needs extra hydrating ingredients like glycerin or hyaluronic acid alongside it to keep the skin comfortable.
Where does this treatment go in a skincare routine for dry skin?
This treatment goes in the evening routine for dry skin, but because exfoliating acids can cause dryness and irritation, a product for this skin needs rich hydrating and softening ingredients instead. Lovi routines start exfoliating steps just once a week, increasing frequency only if well tolerated.
Can I use this treatment with retinol, and in what order?
How often should I use this treatment?
This treatment is a poor fit for dry skin, so use it carefully just once a week to check for irritation, as the exfoliating acids may cause excessive dryness. Dry skin needs products that provide heavy moisture and hydration to keep it soft and smooth.
Can this treatment clog pores, cause breakouts or purging for dry skin?
This treatment is unlikely to clog pores on dry skin, but its exfoliating acids may cause excessive dryness and irritation. A product for this skin type needs rich moisturizing ingredients and soothing agents to lock in hydration and keep the skin soft and smooth.
Is this treatment fragrance-free and alcohol-free?
It has no drying alcohol and contains fragrance (parfum). Cetearyl alcohol is a fatty alcohol, which soften the skin.
What the research says
Cryotherapy with liquid nitrogen achieved a higher cure rate (39%) than salicylic acid (24%) and a wait-and-see approach (16%) for cutaneous warts at 13 weeks in primary care patients.
CMAJ, 2010A moisturizer containing licochalcone A, 1,2-decanediol, L-carnitine, and salicylic acid significantly reduced noninflammatory, inflammatory, and total acne lesion counts compared to a vehicle control in Thai patients during a 12-week maintenance phase.
BioMed Research International, 2020Treatment with 2% supramolecular salicylic acid hydrogel resulted in a regression and markedly improvement rate of 51.01% compared to 43.10% for Adapaline gel in patients with mild to moderate facial acne vulgaris, showing no significant difference in efficacy.
Journal of Cosmetic Dermatology, 2024Repeated short-contact 70% glycolic acid peels provided superior results in atrophic acne scars compared to daily low-strength glycolic acid cream or placebo in 58 women over 24 weeks.
International Journal of Dermatology, 2000Serial glycolic acid peels combined with a modified Kligman formula significantly reduced facial PIH severity in Indian patients compared to the modified Kligman formula alone.
Dermatologic Surgery, 2017A dermocosmetic cream containing Punica granatum Pericarp extract, Salicylic acid, Niacinamide, Zinc gluconate, and Aqua Posae Filiformis significantly decreased inflammatory, non-inflammatory, and total lesion counts in subjects with mild to moderate acne compared to untreated hemi-faces after 15 days.
Journal of Cosmetic Dermatology, 2026Daily use of a deep cleansing gel containing salicylic acid 2%, zinc gluconate 0.2% and lipohydroxy acid 0.05% significantly reduced total lesion count by 56.3% after 84 days in 35 subjects with mild to moderate truncal acne.
Clinical, Cosmetic and Investigational Dermatology, 2023Different strains of Propionibacterium acnes modulate cutaneous innate immunity with varying pro-inflammatory potentials, with P. acnes type III showing the highest and P. avidum the weakest, and zinc gluconate down-regulates the expression of most induced immune markers.
Experimental Dermatology, 2013Silybum marianum flower extract increased human hair follicle dermal papilla cell proliferation and VEGF production while suppressing cellular senescence, and in a clinical study using hair shampoo, it significantly increased hair density and total hair count at 16 and 24 weeks compared with a placebo group.
Journal of Cosmetic Dermatology, 2024Topical 0.5% silymarin-loaded antioxidant serum applied twice daily significantly reduced clinical acne severity, lesion counts, and melanin pigmentation in 22 Korean acne patients over 4 weeks without associated adverse events.
Journal of Cosmetic Dermatology, 2023Topical silymarin cream 1.4% showed comparable results to salicylic acid 30% peels in reducing acne severity in 30 patients with mild to moderate acne vulgaris.
Journal of Cutaneous Medicine and Surgery, 2024Topical treatment with pumpkin seed oil healed uniform wounds in rats, achieving full re-epithelialization, reappearance of skin appendages, and well-organized collagen fibers compared to untreated controls.
Lipids in Health and Disease, 2016A combinational sunscreen formulation of UV filters, melatonin, and pumpkin seed oil ameliorated UV radiation-induced photoaging in adult Wistar albino rats by increasing SOD, GSH-Px, CAT, and collagen levels, while decreasing skin edema, skin thickness, and inflammatory cytokines compared to UV-exposed controls.
European Journal of Pharmaceutical Sciences, 2019Topical pumpkin seed oil increased hair follicle proliferation in mice without causing liver toxicity, oxidative stress, or genotoxicity.
Acta Histochemica, 2022
Ingredients
Water, Propanediol, Proylene Glycol, Glycerin, Cetearyl Alcohol, Cetearyl Glucoside, Glyceryl Stearate, Peg-100 Stearate, Silica, Dimethicone, Bht, Caprylic Capric Triglyceride, Pumpkin Seed Oil, Sodium Hydroxide, Sodium Polyacrylate, Sodium Stearoyl Glutamate, Zinc Gluconate, Capryloyl Glycine, Citric Acid, Parfum, Disodium Edta, Sodium Benzoate, Potassium Sorbate, Glyceryl Laurate, Monolaurin, Silybum Marianum Fruit Extract, Butylene Glycol, Silymarin, Dipotassium Glycyrrhizate, Tocopherol, Glycolic Acid, Salicylic Acid, Xanthan Gum
Behind this fit score
Lovi calculates every fit score from the full ingredient list with brand-independent rules our dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update.
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Co-founder, Medical Director
Cosmetic chemist, cosmetologist, aesthetic products developer
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Co-founder, CEO and CTO
PhD in computer science, 3x US patent holder, ex-Google, ex-Yandex
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Dr. Sofía Perea Pérez, MD, MSc
Medical Board
Aesthetic medicine practitioner, MSc in Longevity and Anti-Aging Medicine
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Medical Board
Specialist dermatologist, MBBS, MD, IFAAD
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Medical Board
Cosmetic chemist, SCS, IFSCC member
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Medical Board, Medical Advisor
Dermatology MD
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Elina Nazarenko, MD
Medical Board
Dermatology and diagnostic consultant
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Victoria Derkova, MS
Medical Board
Cosmetic chemist, cosmetic development technologist
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