Glycolic acid and acetyl hexapeptide-3
Keep them apart
Use them at different times of day with glycolic acid in the morning and acetyl hexapeptide-3 at night because acid ruins peptide strength. Glycolic acid is too acidic and breaks down the peptide, making it stop working. You can use a gentler acid or wait longer between applying them.
Glycolic acid products
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The Ordinary
Glycolic Acid 7% Toning Solution
€12.19
-
RoC
Retinol Correxion Deep Wrinkle Night Cream
€44.90
-
First Aid Beauty
KP Bump Eraser Body Scrub
€26.45
-
First Aid Beauty
Facial Radiance Pads
€124.67
- Murad Rapid Dark Spot Correcting Serum
- Skinbetter Science AlphaRet Overnight Cream
- St. Ives Apricot Scrub
-
COSRX
AHA/BHA Clarifying Treatment Toner
€20.23
-
Dr. Dennis Gross
Alpha Beta Universal Daily Peel
€199.00
-
Pixi
Glow Tonic
€18.05
-
Good Molecules
Overnight Exfoliating Treatment
€22.99
- CeraVe Skin Renewing Nightly Exfoliating Treatment
Acetyl hexapeptide-3 products
-
The Ordinary
Multi-Peptide + Copper Peptides 1% Serum
€34.95
-
The Ordinary
Multi-Peptide + HA Serum
€18.29
-
Medik8
Liquid Peptides
€98.05
-
La Mer
The Treatment Lotion
€143.70
- Rhode Peptide Glazing Fluid
-
The Ordinary
Argireline Solution 10%
€10.58
-
Good Molecules
Super Peptide Serum
€23.92
-
Clinique
Smart Clinical Repair Wrinkle Correcting Serum
€93.33
-
La Mer
The Renewal Oil
€201.44
-
Estée Lauder
Micro Essence Treatment Lotion
€85.99
- The INKEY List Collagen Peptide Serum
-
La Mer
The Eye Concentrate
€189.00
Questions and answers
Can you use glycolic acid and acetyl hexapeptide-3 together?
Keep glycolic acid and acetyl hexapeptide-3 apart because the low pH of glycolic acid destabilizes the peptide and reduces its bioactivity. Use them in separate steps or routines, such as AM and PM separation.
Which goes first, glycolic acid or acetyl hexapeptide-3?
Keep glycolic acid and acetyl hexapeptide-3 apart by using them in separate routines, such as AM and PM, because the low pH of glycolic acid may destabilize the peptide.
Are glycolic acid and acetyl hexapeptide-3 good for sensitive skin?
No, you should keep glycolic acid and acetyl hexapeptide-3 apart because the acidic environment destabilizes peptide bonds and reduces bioactivity. Sensitive skin should avoid low-pH overlap by using these ingredients in separate routines.
Research on glycolic acid and acetyl hexapeptide-3
Behind this pairing advice
Lovi checks every pairing with brand-independent rules our dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update.
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Co-founder, Medical Director
Cosmetic chemist, cosmetologist, aesthetic products developer
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Co-founder, CEO and CTO
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Dr. Sofía Perea Pérez, MD, MSc
Medical Board
Aesthetic medicine practitioner, MSc in Longevity and Anti-Aging Medicine
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Medical Board
Specialist dermatologist, MBBS, MD, IFAAD
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Medical Board
Cosmetic chemist, SCS, IFSCC member
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Medical Board, Medical Advisor
Dermatology MD
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Elina Nazarenko, MD
Medical Board
Dermatology and diagnostic consultant
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Victoria Derkova, MS
Medical Board
Cosmetic chemist, cosmetic development technologist
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