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Glycolic acid and hexapeptide-9

Rated by Lovi · Unbiased, science-based skincare AI trained on real user outcomes · How the Fit score works

Glycolic acid and hexapeptide-9: keep them apart

Keep them apart

Use them at different times of day with the acid first, because the acid breaks down the peptide and stops it from working. The strong acid ruins the peptide, so your skin misses out on the firming benefits. You can easily fix this by using the acid in the morning and the peptide at night.

Glycolic acid products

Hexapeptide-9 products

Questions and answers

Can you use glycolic acid and hexapeptide-9 together?

No, you should keep glycolic acid and hexapeptide-9 apart in your routine. The low pH of glycolic acid may destabilize peptide bonds and reduce the bioactivity of hexapeptide-9.

Which goes first, glycolic acid or hexapeptide-9?

Keep glycolic acid and hexapeptide-9 apart by using them in separate steps or routines, such as alternating between morning and evening. The low pH of glycolic acid destabilizes the peptide bonds in hexapeptide-9, which may reduce its bioactivity.

Are glycolic acid and hexapeptide-9 good for sensitive skin?

Glycolic acid and hexapeptide-9 should be kept apart in your routine because the acidic environment of glycolic acid may destabilize peptide bonds and reduce their bioactivity. Use them in separate steps or routines to protect sensitive skin.

Research on glycolic acid and hexapeptide-9

Behind this pairing advice

Lovi checks every pairing with brand-independent rules our dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update.

  • Nadia Kapleva, MS

    Nadia Kapleva, MS

    Co-founder, Medical Director

    Cosmetic chemist, cosmetologist, aesthetic products developer

  • Alexey Shagraev, PhD

    Alexey Shagraev, PhD

    Co-founder, CEO and CTO

    PhD in computer science, 3x US patent holder, ex-Google, ex-Yandex

  • Dr. Sofía Perea Pérez, MD, MSc

    Dr. Sofía Perea Pérez, MD, MSc

    Medical Board

    Aesthetic medicine practitioner, MSc in Longevity and Anti-Aging Medicine

  • Aishani Shah, MD

    Aishani Shah, MD

    Medical Board

    Specialist dermatologist, MBBS, MD, IFAAD

  • Asya Zubkova, MS

    Asya Zubkova, MS

    Medical Board

    Cosmetic chemist, SCS, IFSCC member

  • Hanna Kurets, MD

    Hanna Kurets, MD

    Medical Board, Medical Advisor

    Dermatology MD

  • Elina Nazarenko, MD

    Elina Nazarenko, MD

    Medical Board

    Dermatology and diagnostic consultant

  • Victoria Derkova, MS

    Victoria Derkova, MS

    Medical Board

    Cosmetic chemist, cosmetic development technologist

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