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Glycolic acid and palmitoyl tripeptide-1

Rated by Lovi · Unbiased, science-based skincare AI trained on real user outcomes · How the Fit score works

Glycolic acid and palmitoyl tripeptide-1: keep them apart

Keep them apart

Use them at different times of day, applying glycolic acid in the morning and the peptide in the evening, because the acid cancels out the peptide. The strong acid breaks down the peptide and stops it from firming your skin. You can use the acid in the morning and the peptide at night to get the benefits of both.

Glycolic acid products

Palmitoyl tripeptide-1 products

Questions and answers

Can you use glycolic acid and palmitoyl tripeptide-1 together?

Keep glycolic acid and palmitoyl tripeptide-1 apart in your routine because the low pH of the acid may destabilize the peptide bonds and reduce their bioactivity. Use them in separate steps or routines, such as AM and PM, to protect your skin.

Which goes first, glycolic acid or palmitoyl tripeptide-1?

Keep glycolic acid and palmitoyl tripeptide-1 apart in your routine because the low pH of glycolic acid destabilizes the peptide bonds and reduces bioactivity.

Are glycolic acid and palmitoyl tripeptide-1 good for sensitive skin?

No, you should keep glycolic acid and palmitoyl tripeptide-1 apart because the low pH of the acid can destabilize the peptide bonds and reduce its effectiveness. For sensitive skin, it is best to use them in separate steps or routines, such as using one in the morning and the other at night.

Research on glycolic acid and palmitoyl tripeptide-1

Behind this pairing advice

Lovi checks every pairing with brand-independent rules our dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update.

  • Nadia Kapleva, MS

    Nadia Kapleva, MS

    Co-founder, Medical Director

    Cosmetic chemist, cosmetologist, aesthetic products developer

  • Alexey Shagraev, PhD

    Alexey Shagraev, PhD

    Co-founder, CEO and CTO

    PhD in computer science, 3x US patent holder, ex-Google, ex-Yandex

  • Dr. Sofía Perea Pérez, MD, MSc

    Dr. Sofía Perea Pérez, MD, MSc

    Medical Board

    Aesthetic medicine practitioner, MSc in Longevity and Anti-Aging Medicine

  • Aishani Shah, MD

    Aishani Shah, MD

    Medical Board

    Specialist dermatologist, MBBS, MD, IFAAD

  • Asya Zubkova, MS

    Asya Zubkova, MS

    Medical Board

    Cosmetic chemist, SCS, IFSCC member

  • Hanna Kurets, MD

    Hanna Kurets, MD

    Medical Board, Medical Advisor

    Dermatology MD

  • Elina Nazarenko, MD

    Elina Nazarenko, MD

    Medical Board

    Dermatology and diagnostic consultant

  • Victoria Derkova, MS

    Victoria Derkova, MS

    Medical Board

    Cosmetic chemist, cosmetic development technologist

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