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Good Molecules vs Sesderma

Rated by Lovi · Unbiased, science-based skincare AI trained on real user outcomes · How the Fit score works

Good Molecules and Sesderma are skincare brands that offer a thoughtful array of targeted treatments for diverse complexions. The American line from 2019 features serums, moisturizers, eye products, and exfoliants with glycerin and hyaluronic acid that suit dry skin, oily skin, acne-prone skin, dark spots, and mature skin best. Meanwhile, the Spanish brand from 1989 is known for advanced serums and engineered formulas with botanical extracts and active compounds that suit sensitive skin, hyperpigmented skin, aging skin, and acne-prone skin best. While both brands emphasize effective formulations, the first relies on barrier-supporting hydration and gentle exfoliation, whereas the second focuses on synergistic active compounds for radiant texture.

Good Molecules is an American skincare brand founded in 2019 and owned by Beautylish, Inc..

beautymatter.comgoodmolecules.compitchbook.compreqin.com

Sesderma is a Spanish skincare brand founded in 1989 and owned by Grupo Sesderma since 2026.

skinexpert.sesderma.comsesderma.com

This page compares some of the most popular Good Molecules and Sesderma products; for every product of both brands, with a fit score for your own skin, use the Lovi app.

Popular Good Molecules vs Sesderma products

Good Molecules vs Sesderma serums and treatments

Questions and answers

Good Molecules or Sesderma: which is better?

Good Molecules is the better choice for shoppers seeking fragrance-free formulas, as every product on its page lists no fragrance compared to Sesderma's Azelac RU Serum which contains fragrance.

What is the difference between Good Molecules and Sesderma?

Good Molecules offers a wide range of fragrance-free products that fit dry, oily, and mature skin best, whereas Sesderma features a single serum on this page that contains fragrance. Reviewers often mention that Good Molecules serums are affordable, lightweight, and gentle.

Which is more affordable, Good Molecules or Sesderma?

Good Molecules reviewers mostly mention the brand as affordable and offering great value serums alongside affordable and hydrating moisturizers, while the page features no such affordability details for Sesderma.

Which causes fewer breakouts, Good Molecules or Sesderma?

Good Molecules may cause fewer breakouts than Sesderma because every product on the Good Molecules page lists no fragrance, whereas the Azelac RU Serum by Sesderma includes fragrance.

Which brand has been on the market longer, Good Molecules or Sesderma?

Sesderma has been on the market longer, having been founded in Spain in 1989, whereas Good Molecules was founded in the United States in 2019.

Do any products from Good Molecules contain fragrance compared to Sesderma?

Every product on the Good Molecules page lists no fragrance in its ingredients, whereas the Azelac RU Serum from Sesderma contains fragrance.

Which skin types does the Azelac RU Serum by Sesderma fit best?

The Azelac RU Serum by Sesderma has a Lovi fit level of High for acne-prone skin, skin with dark spots, and combination skin.

Research behind their key ingredients

Behind this comparison

Lovi compares products by their fit scores, calculated from the full ingredient list with brand-independent rules our dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update.

  • Nadia Kapleva, MS

    Nadia Kapleva, MS

    Co-founder, Medical Director

    Cosmetic chemist, cosmetologist, aesthetic products developer

  • Alexey Shagraev, PhD

    Alexey Shagraev, PhD

    Co-founder, CEO and CTO

    PhD in computer science, 3x US patent holder, ex-Google, ex-Yandex

  • Dr. Sofía Perea Pérez, MD, MSc

    Dr. Sofía Perea Pérez, MD, MSc

    Medical Board

    Aesthetic medicine practitioner, MSc in Longevity and Anti-Aging Medicine

  • Aishani Shah, MD

    Aishani Shah, MD

    Medical Board

    Specialist dermatologist, MBBS, MD, IFAAD

  • Asya Zubkova, MS

    Asya Zubkova, MS

    Medical Board

    Cosmetic chemist, SCS, IFSCC member

  • Hanna Kurets, MD

    Hanna Kurets, MD

    Medical Board, Medical Advisor

    Dermatology MD

  • Elina Nazarenko, MD

    Elina Nazarenko, MD

    Medical Board

    Dermatology and diagnostic consultant

  • Victoria Derkova, MS

    Victoria Derkova, MS

    Medical Board

    Cosmetic chemist, cosmetic development technologist

How does it fit your skin?

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