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Good Molecules vs Sesderma

Rated by Lovi · Unbiased, science-based skincare AI trained on real user outcomes · How the Fit score works

Good Molecules and Sesderma are distinguished skincare brands that offer thoughtful serums, moisturizers, eye products, and exfoliants featuring key ingredients like glycerin and hyaluronic acid alongside advanced botanical extracts. The American line suits sensitive and acne-prone skin best, while the Spanish counterpart caters well to sensitive, hyperpigmented, and aging skin types. Both deliver notable benefits through meticulously engineered formulas, though the first focuses on restoring barrier function and hydration while the second emphasizes refining texture and promoting radiance.

Good Molecules is an American skincare brand founded in 2019 and owned by Beautylish, Inc..

beautymatter.comgoodmolecules.compitchbook.compreqin.com

Sesderma is a Spanish skincare brand founded in 1989 and owned by Grupo Sesderma since 2026.

skinexpert.sesderma.comsesderma.com

This page compares some of the most popular Good Molecules and Sesderma products; for every product of both brands, with a fit score for your own skin, use the Lovi app.

Popular Good Molecules vs Sesderma products

Good Molecules vs Sesderma serums and treatments

Questions and answers

Good Molecules or Sesderma: which is better?

Good Molecules is the better choice for shoppers looking for a wider variety of options, as the products on this page cover multiple skincare categories with no fragrance listed across the entire range, whereas Sesderma only features a single serum that contains fragrance.

What is the difference between Good Molecules and Sesderma?

Good Molecules offers a much wider range of products on this page compared to Sesderma, and every Good Molecules product lists no fragrance. In addition, Good Molecules fits sensitive skin, acne-prone skin, and dry sensitive skin best.

Which is more affordable, Good Molecules or Sesderma?

Good Molecules is more affordable, offering budget-friendly serums that reviewers frequently praise for great value.

Which causes fewer breakouts, Good Molecules or Sesderma?

Good Molecules has multiple acne-prone skin options on this page, whereas Sesderma lists only one serum that has a High fit level for acne-prone skin. Reviewers note that Good Molecules sometimes causes breakouts.

How do the founding years and countries of origin compare between Good Molecules and Sesderma?

Good Molecules was founded in 2019 in the United States, whereas Sesderma was founded earlier in 1989 in Spain.

Which brand has more fragrance-free options among their listed products, Good Molecules or Sesderma?

Good Molecules has more fragrance-free options because every product on its page lists no fragrance, whereas the single Sesderma product on this page includes fragrance.

What is the Lovi fit level of Sesderma's Azelac RU Serum for dry skin compared to Good Molecules serums?

Sesderma's Azelac RU Serum has a Low Lovi fit level for dry skin, whereas Good Molecules serums range from Average to High or Superior for dry skin.

Research behind their key ingredients

Behind this comparison

Lovi compares products by their fit scores, calculated from the full ingredient list with brand-independent rules our dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update.

  • Nadia Kapleva, MS

    Nadia Kapleva, MS

    Co-founder, Medical Director

    Cosmetic chemist, cosmetologist, aesthetic products developer

  • Alexey Shagraev, PhD

    Alexey Shagraev, PhD

    Co-founder, CEO and CTO

    PhD in computer science, 3x US patent holder, ex-Google, ex-Yandex

  • Dr. Sofía Perea Pérez, MD, MSc

    Dr. Sofía Perea Pérez, MD, MSc

    Medical Board

    Aesthetic medicine practitioner, MSc in Longevity and Anti-Aging Medicine

  • Aishani Shah, MD

    Aishani Shah, MD

    Medical Board

    Specialist dermatologist, MBBS, MD, IFAAD

  • Asya Zubkova, MS

    Asya Zubkova, MS

    Medical Board

    Cosmetic chemist, SCS, IFSCC member

  • Hanna Kurets, MD

    Hanna Kurets, MD

    Medical Board, Medical Advisor

    Dermatology MD

  • Elina Nazarenko, MD

    Elina Nazarenko, MD

    Medical Board

    Dermatology and diagnostic consultant

  • Victoria Derkova, MS

    Victoria Derkova, MS

    Medical Board

    Cosmetic chemist, cosmetic development technologist

How does it fit your skin?

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