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Good Molecules vs Sesderma

Rated by Lovi · Unbiased, science-based skincare AI trained on real user outcomes · How the Fit score works

Good Molecules and Sesderma are distinguished skincare brands that offer thoughtful serums, moisturizers, eye products, and exfoliants featuring key ingredients like glycerin and hyaluronic acid alongside advanced botanical extracts. The American line suits sensitive and acne-prone skin best, while the Spanish counterpart caters well to sensitive, hyperpigmented, and aging skin types. Both deliver notable benefits through meticulously engineered formulas, though the first focuses on restoring barrier function and hydration while the second emphasizes refining texture and promoting radiance.

Good Molecules is an American skincare brand founded in 2019 and owned by Beautylish, Inc..

beautymatter.comgoodmolecules.compitchbook.compreqin.com

Sesderma is a Spanish skincare brand founded in 1989 and owned by Grupo Sesderma since 2026.

skinexpert.sesderma.comsesderma.com

This page compares some of the most popular Good Molecules and Sesderma products; for every product of both brands, with a fit score for your own skin, use the Lovi app.

Popular Good Molecules vs Sesderma products

Good Molecules vs Sesderma serums and treatments

Questions and answers

Good Molecules or Sesderma: which is better?

Good Molecules provides a much wider selection of fragrance-free products on this page compared to Sesderma, and Lovi rates its Sheer Mineral Sunscreen SPF 30 as a Superior fit for dry and sensitive skin.

What is the difference between Good Molecules and Sesderma?

Good Molecules offers a wide range of products that list no fragrance and fit sensitive skin and skin with dark spots well, whereas Sesderma currently features just one product on this page, which contains fragrance.

Which is more affordable, Good Molecules or Sesderma?

Good Molecules is the more affordable brand, with reviewers frequently highlighting its affordable and great value serums and moisturizers. In contrast, Sesderma features a high-end positioning with products like its Azelac RU Serum priced at higher points without comparable bulk affordability.

Which causes fewer breakouts, Good Molecules or Sesderma?

Good Molecules may cause fewer breakouts than Sesderma because every product on the Good Molecules page lists no fragrance, whereas the Azelac RU Serum from Sesderma contains fragrance.

Which brand has more fragrance-free products, Good Molecules or Sesderma?

Good Molecules has more fragrance-free products, as every single product on its page lists no fragrance in its ingredients, whereas Sesderma has fragrance in its only product listed on the page.

Which company was founded earlier and in which country, Good Molecules or Sesderma?

Sesderma was founded earlier in Spain in 1989, while Good Molecules was founded in the United States in 2019.

How does the Lovi fit level for dry skin compare between Good Molecules and Sesderma products?

Good Molecules offers several products on this page with a Superior or High Lovi fit level for dry skin, such as the Lightweight Daily Moisturizer and Sheer Mineral Sunscreen SPF 30. In contrast, Sesderma has only one product on this page, the Azelac RU Serum, which has a Low fit level for dry skin.

Research behind their key ingredients

Behind this comparison

Lovi compares products by their fit scores, calculated from the full ingredient list with brand-independent rules our dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update.

  • Nadia Kapleva, MS

    Nadia Kapleva, MS

    Co-founder, Medical Director

    Cosmetic chemist, cosmetologist, aesthetic products developer

  • Alexey Shagraev, PhD

    Alexey Shagraev, PhD

    Co-founder, CEO and CTO

    PhD in computer science, 3x US patent holder, ex-Google, ex-Yandex

  • Dr. Sofía Perea Pérez, MD, MSc

    Dr. Sofía Perea Pérez, MD, MSc

    Medical Board

    Aesthetic medicine practitioner, MSc in Longevity and Anti-Aging Medicine

  • Aishani Shah, MD

    Aishani Shah, MD

    Medical Board

    Specialist dermatologist, MBBS, MD, IFAAD

  • Asya Zubkova, MS

    Asya Zubkova, MS

    Medical Board

    Cosmetic chemist, SCS, IFSCC member

  • Hanna Kurets, MD

    Hanna Kurets, MD

    Medical Board, Medical Advisor

    Dermatology MD

  • Elina Nazarenko, MD

    Elina Nazarenko, MD

    Medical Board

    Dermatology and diagnostic consultant

  • Victoria Derkova, MS

    Victoria Derkova, MS

    Medical Board

    Cosmetic chemist, cosmetic development technologist

How does it fit your skin?

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