NEOCUTIS Bio Serum Firm for skin with dark spots

How to apply

Questions and answers

What the research says

• Chronomodulated daytime application of baicalin and nighttime application of palmitoyl tripeptide-1 synergistically improved skin luminance by 16.29%, nasolabial fold depth by -36.35%, and firmness by 24.35% in 30 female participants.

  Journal of Cosmetic Dermatology, 2026

• A multi-modal methodology combining MALDI-MSI, in vivo RCM, echography, and histology revealed age-related decreases in extracellular matrix and epidermal-dermal junction proteins and undulation depth, while a blend of palmitoyl oligopeptide and palmitoyl tetrapeptide-7 improved subepidermal low-echogenic band thickness, density, and extracellular matrix structure compared to placebo.

  Journal of Cosmetic Dermatology, 2015

• Palmitoyl tetrapeptide-7, acetyl hexapeptide-8, palmitoyl tripeptide-1, and palmitoyl tetrapeptide-10 significantly increased type III collagen levels in human dermal fibroblasts following UV exposure, with their combination demonstrating a greater effect in vitro and enhancing type I, III, and IV collagen levels in ex vivo skin tissues compared to individual components.

  International Journal of Cosmetic Science, 2026

• A single application of a moisturizing fluid containing hyaluronic acid 1%, glycerin 5%, and Centella asiatica stem cells extract significantly increased skin hydration by 29% and reduced transepidermal water loss at 24 hours compared to baseline and an untreated control site in twenty healthy women.

  Clinical, Cosmetic and Investigational Dermatology, 2017

• Topical application of 0.1% hyaluronic acid formulations of different molecular weights led to significant improvements in skin hydration and elasticity, with low-molecular-weight formulations also significantly reducing wrinkle depth in seventy-six female subjects compared to a vehicle control.

  Journal of Drugs in Dermatology, 2011

• Topical application of hyaluronic acid in conjunction with free gingival graft significantly reduced donor site postoperative pain until day 7 compared to normal saline, with no significant differences in graft dimensions or patient satisfaction.

  Clinical Oral Investigations, 2022

• Treatment with a hyaluronic acid-containing mouth rinse or topical gel led to significant lesion reduction, pain relief, and normalization of lesion color in adult patients with minor recurrent aphthous stomatitis, with the gel formulation showing an earlier healing onset at 3 days.

  BMC Oral Health, 2019

• Topical 2% N-acetyl glucosamine reduced facial hyperpigmentation in an 8-week split-face clinical test, with an even greater effect observed when combined with 4% niacinamide.

  Journal of Cosmetic Dermatology, 2007

• N-acetyl-glucosamine-loaded nanostructured lipid carriers successfully delivered the hydrophilic agent through the skin and reduced melanin distribution in healthy volunteers.

  Advanced Pharmaceutical Bulletin, 2016

• Topical cosmetic products containing hyaluronic acid, N-acetyl glucosamine, and gamma-amino butyric acid improved skin hydration by 24.28% to 33.60%, elasticity by 11.98%, and skin lightening by 5.26% over 2 months in 20 female participants.

  Journal of Cosmetic and Laser Therapy, 2019

• Topical application of 5% vitamin C cream significantly improved global clinical scores, increased skin microrelief density, and induced elastic tissue repair in photoaged skin compared to excipient control in healthy female volunteers.

  Experimental Dermatology, 2003

• Ascorbic acid 2-glucoside gel significantly reduced gingival melanin pigmentation after 4 weeks compared to placebo in 73 subjects with symmetric pigmentation.

  Journal of Periodontology, 2009

• Topical application of VC-IP cream twice daily for 8 weeks reduces periorbital wrinkles in female subjects compared to a placebo cream.

  Journal of Cosmetic Dermatology, 2022

Ingredients

Water, Glycerin, Caprylic Capric Triglyceride, Hydroxyethyl Acrylate Sodium Acryloyldimethyl Taurate Copolymer, Squalane, Aminopropyl Ascorbyl Phosphate, Sodium Hyaluronate, Hydrolyzed Sodium Hyaluronate, Cutaneous Lysate, Tetrapeptide-21, Palmitoyl Tripeptide-1 Acetate, Butylene Glycol, Ethylhexylglycerin, Pullulan, Acetyl Glucosamine, Ethylene Acrylic Acid Copolymer, Polysorbate 60, Proline, Arginine, Glycine, Glutamine, Chlorphenesin, Nannochloropsis Oculata Extract, Capryloyl Carnosine, Poloxamer 338, Silica, Trifluoroacetyl Tripeptide-2, Dextran, Sorbitan Isostearate, Potassium Sorbate, Sodium Benzoate, Tocopherol, Disodium Edta, Sodium Hydroxide, Phenoxyethanol

Behind this fit score

Lovi calculates every fit score from the full ingredient list with brand-independent rules our dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update.