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Acetyl hexapeptide-3

Rated by Lovi · Unbiased, science-based skincare AI trained on real user outcomes · How the Fit score works

Acetyl hexapeptide-3

Acetyl hexapeptide-3 softens the look of wrinkles, lessens skin roughness, and boosts skin hydration. It suits dry skin and oily skin best, and comes in serums, creams, eye creams, and masks. It fits well into a routine with panthenol, green tea, and ceramide-building complex, but you should keep it apart from adapalene, glycolic acid, and benzoyl peroxide.

American Journal of Clinical Dermatology, 2013Annals of Dermatology, 2019Journal of Cosmetic Dermatology, 2017

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Acetyl hexapeptide-3 serums

What reviewers say about popular acetyl hexapeptide-3 products

The highlight reviewers mention most for each popular acetyl hexapeptide-3 product on Lovi.

Acetyl hexapeptide-3 creams

Acetyl hexapeptide-3 eye creams

Acetyl hexapeptide-3 masks

Acetyl hexapeptide-3 for dry skin

Acetyl hexapeptide-3 for oily skin

Acetyl hexapeptide-3 for combination skin

All acetyl hexapeptide-3 products

See all 49 acetyl hexapeptide-3 products

What to combine acetyl hexapeptide-3 with

IngredientTogetherHow to use them
Panthenol Works well Use them together in the same routine, applying panthenol first and acetyl hexapeptide-3 second, for better anti-aging and skin repair. Acetyl hexapeptide-3 and panthenol
Green tea Works well Use them together, applying the green tea first and the peptide second, for better protection against everyday skin aging. Acetyl hexapeptide-3 and green tea
Ceramide-building complex Works well Use them together in the same routine, applying the peptide serum first and following with the ceramide cream. Acetyl hexapeptide-3 and ceramide-building complex
Glycerin Works well Use them together by applying the glycerin serum before the peptide product, because hydration helps the peptide work better. Acetyl hexapeptide-3 and glycerin
Coenzyme Q10 Works well Use them together in the same routine, applying the coenzyme Q10 first and the peptide second for the best anti-aging results. Acetyl hexapeptide-3 and coenzyme q10
Vitamin E Works well Use them together in the same routine, applying the peptide first and the vitamin E right after, because vitamin E keeps peptides fresh and strong. Acetyl hexapeptide-3 and vitamin E
Bakuchiol Works well Use them together in the same routine, applying bakuchiol first and acetyl hexapeptide-3 right after for smoother, firmer skin. Acetyl hexapeptide-3 and bakuchiol
Silk amino acids Works well Use them together, applying silk amino acids first and acetyl hexapeptide-3 right after, to boost hydration and repair. Acetyl hexapeptide-3 and silk amino acids
Arginine Works well Use them together, applying the amino acid first and the peptide right after, because they help each other keep your skin hydrated and firm. Acetyl hexapeptide-3 and arginine
Liposome Works well Use them together by applying the liposome product first, because the liposome protects the peptide from breaking down. Acetyl hexapeptide-3 and liposome
Taurine Works well Use them together in the morning and evening, because taurine helps peptides work better for your skin. Acetyl hexapeptide-3 and taurine
Hyaluronic acid Works well Apply the hyaluronic acid first and the peptide product right after, because they work wonderfully when used in the same routine. Acetyl hexapeptide-3 and hyaluronic acid
Microcapsule Works well Use them together in the same routine, applying the microcapsule first to help the peptide absorb better and last longer. Acetyl hexapeptide-3 and microcapsule
Cholesterol Works well Use them together in the same routine, applying the peptide first and the cholesterol right after. Acetyl hexapeptide-3 and cholesterol
Phytosphingosine Works well Use them together in the same routine, applying the peptide product first followed by the ceramide cream, for better barrier support. Acetyl hexapeptide-3 and phytosphingosine
Betaine Works well Use them together by applying the hydrating serum first, because moisture helps the anti-wrinkle peptide work better. Acetyl hexapeptide-3 and betaine
Phytosterol Works well Use them together in the same routine, applying the peptide first and the plant lipid second for better moisture. Acetyl hexapeptide-3 and phytosterol
Beta-sitosterol Works well Use them together in the same routine, applying the plant sterol first and the peptide right after, because lipids help peptides absorb better. Acetyl hexapeptide-3 and beta-sitosterol
Squalene Works well Use them together in the same routine, applying the squalene after the peptide. Acetyl hexapeptide-3 and squalene
Tri-ceramide complex Works well Use them together in the same routine, applying the peptide serum first followed by the ceramide cream, because lipids help peptides absorb better. Acetyl hexapeptide-3 and tri-ceramide complex
GABA Works well Use them together, applying the peptide first and GABA second, for better skin firmness and hydration. Acetyl hexapeptide-3 and GABA
Theanine Works well Use acetyl hexapeptide-3 and theanine together in the same routine, applying them at the same time to help your skin stay hydrated and firm. Acetyl hexapeptide-3 and theanine
Vitamin C Depends Apply vitamin C in the morning and acetyl hexapeptide-3 at night, because combining them in the same routine makes them less effective. Acetyl hexapeptide-3 and vitamin C
Retinol Depends Use them at different times of day with retinol at night and peptides in the morning, because combining strong retinoids and peptides can cause irritation. Acetyl hexapeptide-3 and retinol
Niacinamide Depends Use them together in the same routine, because niacinamide helps strengthen your skin while peptides work on firmness. Acetyl hexapeptide-3 and niacinamide
Adapalene Keep apart Use them at different times of day by applying acetyl hexapeptide-3 in the morning and adapalene at night, because strong retinoids should not be mixed with peptides in the same routine. Acetyl hexapeptide-3 and adapalene
Glycolic acid Keep apart Use them at different times of day with glycolic acid in the morning and acetyl hexapeptide-3 at night because acid ruins peptide strength. Acetyl hexapeptide-3 and glycolic acid
Benzoyl peroxide Keep apart Use them at different times of day, applying the peptide cream in the morning and benzoyl peroxide at night, because they clash and cancel each other out. Acetyl hexapeptide-3 and benzoyl peroxide
Azelaic acid Keep apart Use them at different times of day by applying azelaic acid in the morning and acetyl hexapeptide-3 at night, because acids break down peptides. Acetyl hexapeptide-3 and azelaic acid
AHA blend glycolic and citric acids Keep apart Apply aha blend glycolic and citric acids in the morning and acetyl hexapeptide-3 at night because acids break down peptides. Acetyl hexapeptide-3 and aha blend glycolic and citric acids
Salicylic acid Keep apart Use them at different times of day, applying salicylic acid first and peptides later, because the acid breaks down the peptides. Acetyl hexapeptide-3 and salicylic acid
Tretinoin Keep apart Use them at different times of day by applying acetyl hexapeptide-3 in the morning and tretinoin at night to prevent irritation. Acetyl hexapeptide-3 and tretinoin
Vitamin A Keep apart Use them at different times of day, applying the peptide product in the morning and the vitamin A at night, to avoid extra skin irritation. Acetyl hexapeptide-3 and vitamin A
Pro-retinol Keep apart Use them at different times of day with proretinol at night and acetyl hexapeptide-three in the morning to prevent extra skin irritation. Acetyl hexapeptide-3 and pro-retinol
Retinal Keep apart Use them at different times of day, applying retinal at night and acetyl hexapeptide-3 in the morning to avoid skin irritation. Acetyl hexapeptide-3 and retinal
Copper Keep apart Use them on alternate nights, applying copper peptides on even days and acetyl hexapeptide-3 on odd days, to get the best results. Acetyl hexapeptide-3 and copper
Magnesium Keep apart Use them at different times of day, applying the peptide first and the magnesium later, because mixing them makes the peptide less effective. Acetyl hexapeptide-3 and magnesium
Lactic acid Keep apart Use them at different times of day, applying lactic acid in the morning and acetyl hexapeptide-3 at night, to prevent the acid from breaking down the peptide. Acetyl hexapeptide-3 and lactic acid
Mandelic acid Keep apart Use them at different times of day by applying your acid first and your peptide later, because acids break down peptides. Acetyl hexapeptide-3 and mandelic acid
Retinoid blend Keep apart Use them at different times of day by applying the peptide serum in the morning and the retinoid at night to prevent skin irritation. Acetyl hexapeptide-3 and retinoid blend
Superoxide dismutase Keep apart Use them at different times of day, applying the peptide first and the enzyme later, because they cancel each other out. Acetyl hexapeptide-3 and superoxide dismutase
Polyvinyl alcohol Keep apart Use them at different times of day, applying the peptide first and the alcohol product later. Acetyl hexapeptide-3 and polyvinyl alcohol
Zinc Keep apart Use zinc and acetyl hexapeptide-3 at different times of day, applying zinc in the morning and the peptide at night, because they clash and cancel each other out. Acetyl hexapeptide-3 and zinc
Zinc sulfate Keep apart Use them at different times of day, applying the peptide first, because they cancel each other out. Acetyl hexapeptide-3 and zinc sulfate
Bleach Keep apart Use them at different times of day, applying the peptide first and the bleach later, because bleach ruins the peptide. Acetyl hexapeptide-3 and bleach
Granactive retinoid Keep apart Use them at different times of day by applying your peptide product in the morning and your retinoid at night. Acetyl hexapeptide-3 and granactive retinoid
Hydroxypinacolone retinoate Keep apart Use them at different times of day by applying the peptide product in the morning and the retinoid at night to avoid skin irritation. Acetyl hexapeptide-3 and hydroxypinacolone retinoate
Potassium hydroxide Keep apart Use them at different times of day, applying acetyl hexapeptide-3 first and potassium hydroxide later, because they clash in acidity. Acetyl hexapeptide-3 and potassium hydroxide
Citric acid Keep apart Use them at different times of day, applying the acid first and the peptide second, because acid breaks down the peptide. Acetyl hexapeptide-3 and citric acid
Isopropyl alcohol Keep apart Apply the peptide product first, wait ten minutes, and then use the alcohol product later, because harsh solvents can ruin anti-aging results. Acetyl hexapeptide-3 and isopropyl alcohol
Behenyl alcohol Keep apart Apply them at different times of day, using the peptide first and the alcohol later, because heavy alcohols can break down the peptide structure. Acetyl hexapeptide-3 and behenyl alcohol
Protease Keep apart Use them at different times of day, applying acetyl hexapeptide-3 in the morning and protease at night, because they clash when mixed. Acetyl hexapeptide-3 and protease
Baking soda Keep apart Use them at different times of day, applying the peptide first and the baking soda later, because they clash in chemical balance. Acetyl hexapeptide-3 and baking soda

From the ingredient rules behind the "Works well with" and "Don't mix with" notes on every product in the Lovi app.

Questions and answers

What does acetyl hexapeptide-3 do for the skin?

Acetyl hexapeptide-3 helps smooth wrinkles and decrease skin roughness when applied twice daily. Lovi rates the fit for anti-aging care as Superior.

American Journal of Clinical Dermatology, 2013Journal of Cosmetic and Laser Therapy, 2013

How do you use acetyl hexapeptide-3?

You can use acetyl hexapeptide-3 twice daily to help reduce wrinkles and skin roughness. When combining it with active ingredients, use compatible ones like panthenol or hyaluronic acid in your routine, while keeping acids and retinoids separate at different times of day.

American Journal of Clinical Dermatology, 2013Journal of Cosmetic and Laser Therapy, 2013

Should you use acetyl hexapeptide-3 in the morning or at night?

You may use acetyl hexapeptide-3 twice daily, as consistent application helps produce significant anti-wrinkle effects and decreases skin roughness.

American Journal of Clinical Dermatology, 2013Journal of Cosmetic and Laser Therapy, 2013

Can you use acetyl hexapeptide-3 every day?

Yes, you can use acetyl hexapeptide-3 every day by applying it twice daily for four weeks to help reduce wrinkle depth and decrease skin roughness. Lovi assigns this ingredient an Average fit for daily anti-aging routines.

American Journal of Clinical Dermatology, 2013Journal of Cosmetic and Laser Therapy, 2013

Does acetyl hexapeptide-3 cause purging or irritation?

Acetyl hexapeptide-3 is unlikely to cause skin purging because it does not speed up cell turnover, and it is generally well tolerated without causing significant irritation when used alone. Lovi finds the overall fit for this ingredient to be High.

Which skin types is acetyl hexapeptide-3 best for?

Acetyl hexapeptide-3 is suitable for all skin types, with top-rated product fits varying depending on your specific skin concerns. For dry skin, Lovi rates myąyo Bifida Biome Complex Ampoule, The Ordinary Multi-Peptide + HA Serum, and La Mer The Treatment Lotion as Superior fits. For mature skin, Lovi lists Clinique Smart Clinical Repair Lifting Face + Neck Cream, La Mer The Treatment Lotion, and Origins Plantscription Powerful Lifting Overnight Mask as Superior fits.

Can you use acetyl hexapeptide-3 with panthenol?

Yes, you can use acetyl hexapeptide-3 with panthenol together in the same routine, applying panthenol first and acetyl hexapeptide-3 second, for better anti-aging and skin repair.

Can you use acetyl hexapeptide-3 with adapalene?

You should keep acetyl hexapeptide-3 and adapalene apart by using them at different times of day, applying acetyl hexapeptide-3 in the morning and adapalene at night, because strong retinoids should not be mixed with peptides in the same routine.

Research on acetyl hexapeptide-3

Behind this ingredient guide

Lovi checks every ingredient with brand-independent rules our dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update.

  • Nadia Kapleva, MS

    Nadia Kapleva, MS

    Co-founder, Medical Director

    Cosmetic chemist, cosmetologist, aesthetic products developer

  • Alexey Shagraev, PhD

    Alexey Shagraev, PhD

    Co-founder, CEO and CTO

    PhD in computer science, 3x US patent holder, ex-Google, ex-Yandex

  • Dr. Sofía Perea Pérez, MD, MSc

    Dr. Sofía Perea Pérez, MD, MSc

    Medical Board

    Aesthetic medicine practitioner, MSc in Longevity and Anti-Aging Medicine

  • Aishani Shah, MD

    Aishani Shah, MD

    Medical Board

    Specialist dermatologist, MBBS, MD, IFAAD

  • Asya Zubkova, MS

    Asya Zubkova, MS

    Medical Board

    Cosmetic chemist, SCS, IFSCC member

  • Hanna Kurets, MD

    Hanna Kurets, MD

    Medical Board, Medical Advisor

    Dermatology MD

  • Elina Nazarenko, MD

    Elina Nazarenko, MD

    Medical Board

    Dermatology and diagnostic consultant

  • Victoria Derkova, MS

    Victoria Derkova, MS

    Medical Board

    Cosmetic chemist, cosmetic development technologist

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