Perricone MD Cold Plasma Plus+ for mature skin
Ascorbic Acid Ester
Copper Tripeptide
Acetyl Hexapeptide-8
Omega 3
Glycolic AcidAverage
- HighNormal Skin Fit
- AverageEffectiveness
- HighSafety
Works for mature skin; other serums fit it better.
- Clinical, Cosmetic and Investigational Dermatology, 2017
- American Journal of Clinical Dermatology, 2013
This fit is calculated for the concerns frequently associated with mature skin: fine lines, wrinkles, and loss of firmness. For scores and recommendations based on your full skin profile, including your 12D face scan results and any goals or preferences you have, please use the Lovi app.
Page built Nov 8, 2026How the Fit score works
Lovi Assistant explains
- Offers moderate benefits for your normal skin, as Glycerin and Sodium Hyaluronate provide hydration while Tetrahexyldecyl Ascorbate and Retinyl Palmitate offer antioxidant support, though they are not specialized for targeting wrinkles and fine lines.
- The presence of Acetyl Hexapeptide-8 and Glycolic Acid contributes to smoothing texture and minimizing fine lines, enhancing the product's overall efficacy for general skincare.
- The product is safe for your normal skin, with no risks of irritation due to the absence of prohibited or harsh ingredients.
How to apply
- Use this serum in your PM routine. Start by applying it 3 times a week, and work up to daily use if your skin likes it.
- Apply this serum after your toner and before your moisturizer.
- Gently press 2-3 drops of the serum into your skin and let it absorb for a minute.
- You can apply the serum on dry skin for the best results against fine lines.
- Always do a patch test before your first use and avoid the sensitive eye area.
People Say
★4.2Overall rating based on 1.5k+ reviewsBased on a very large amount of data, users frequently praise this serum for its ability to dramatically smooth rough texture and minimize the appearance of pores, often delivering visible results within a few weeks. While many report firmer, more radiant skin and improved tone, a significant number of reviewers struggle with its distinct scent and high price point.
Highlights
Unpleasant scent Mostly Mentioned
- “smells like fish”
- “scent is off-putting”
- “earthy and funky smell”
- “hard to get past the smell”
Improves skin texture Often Mentioned
- “smooths my skin overnight”
- “minimized my large pores”
- “texture is not grainy anymore”
- “skin feels fantastic”
High price tag Often Mentioned
- “very expensive product”
- “not worth the money”
- “price is steep”
- “waiting for a sale”
Fast absorption Sometimes Noted
- “absorbs pretty quickly”
- “sinks right in”
- “lightweight and not sticky”
- “non-greasy finish”
Increases radiance Sometimes Noted
- “saw more radiance”
- “brightening dark spots”
- “skin looks youthful”
- “helps with dullness”
Reduces fine lines Sometimes Noted
- “softens crow's feet”
- “lines appear diminished”
- “helps with wrinkles”
- “skin looks plumper”
Packaging issues Rarely Noted
- “jar is unsanitary”
- “pump stopped working”
- “hard to get product out”
- “prefer a bottle”
Skin irritation Rarely Noted
- “caused redness and burning”
- “broke me out”
- “too strong for sensitive skin”
- “caused dry patches”
Sources: lovi.care, ulta.com, perriconemd.com, amazon.com, sephora.co.uk, lovelyskin.com, and more
Questions and answers
How well does Cold Plasma Plus+ work for mature skin?
Perricone MD Cold Plasma Plus+ works as an average fit for mature skin, providing hydration and smoothing texture while lacking specialized ingredients for targeting wrinkles and fine lines. To truly care for mature skin, a product of this type needs high-quality ingredients that effectively target wrinkles and fine lines, offer strong anti-aging functions, and improve skin elasticity.
Clinical, Cosmetic and Investigational Dermatology, 2017American Journal of Clinical Dermatology, 2013
Which ingredients make this treatment a good fit for mature skin?
Acetyl hexapeptide-8 and glycolic acid help smooth texture and minimize fine lines, while glycerin and sodium hyaluronate keep your skin hydrated. To fit mature skin best, a product of this type needs specialized ingredients that strongly target wrinkles and fine lines, along with potent antioxidants and skin-repairing components.
Clinical, Cosmetic and Investigational Dermatology, 2017American Journal of Clinical Dermatology, 2013
What does Ascorbic Acid do for mature skin?
Ascorbic acid helps make mature skin look smoother and firmer while reducing fine lines and wrinkles. It supports collagen building and helps protect against daily skin damage.
Journal of Cosmetic Dermatology, 2021Archives of Otolaryngology--head & Neck Surgery, 1999
What does Copper Tripeptide do for mature skin?
Copper Tripeptide helps smooth fine lines and firms mature skin by boosting collagen and calming irritation. It also supports skin elasticity and overall barrier health, making it a great addition to anti-aging routines.
Skin Research and Technology, 2026Oxidative Medicine and Cellular Longevity, 2012
Where does this treatment go in a skincare routine for mature skin?
This treatment goes in the evening routine after cleansing and before your moisturizer. Mature skin needs products with specialized peptides, retinoids, and antioxidants that deeply target fine lines and firmness.
Can I use this treatment with niacinamide, and in what order?
You can use this treatment with niacinamide by applying niacinamide first and following with this treatment once it absorbs, which helps keep your skin calm and smooth. This product is unlikely to irritate your skin since it lacks harsh ingredients.
How often should I use this treatment?
This treatment fits into your evening routine once a week to start, as Lovi routines start exfoliating steps cautiously with once a week. People who tolerate them well and see good results can carefully use them more often.
Can this treatment clog pores, cause breakouts or purging for mature skin?
This treatment is unlikely to clog pores or cause breakouts for mature skin, as it has a very low risk of skin irritation and features gentle hydrating ingredients. To properly care for mature skin, a product of this type needs firming peptides and specialized ingredients that directly target wrinkles and fine lines.
Is this treatment fragrance-free and alcohol-free?
Yes, it has no fragrance and no drying alcohol. Cetearyl alcohol is a fatty alcohol, which soften the skin.
What the research says
A single application of a moisturizing fluid containing hyaluronic acid 1%, glycerin 5%, and Centella asiatica stem cells extract significantly increased skin hydration by 29% and reduced transepidermal water loss at 24 hours compared to baseline and an untreated control site in twenty healthy women.
Clinical, Cosmetic and Investigational Dermatology, 2017Argireline treatment twice daily for 4 weeks produced a significant anti-wrinkle effect with 48.9% total efficacy and decreased skin roughness in Chinese subjects compared with 0% efficacy and no decrease in roughness in the placebo group.
American Journal of Clinical Dermatology, 2013Treatment with cross-linked hyaluronic acid-based microneedle patches combined with acetyl hexapeptide-8 or epidermal growth factor significantly improved wrinkles and skin hydration compared to the patch alone in Korean females over 29 days.
Annals of Dermatology, 2019Acetyl hexapeptide-3 and tripeptide-10 citrulline demonstrated antiwrinkle efficacy and decreased transepidermal water loss in twenty-four healthy volunteers compared to control groups, though synergistic effects between the two peptides remained unclear.
Journal of Cosmetic Dermatology, 2017Topical application of 5% vitamin C cream significantly improved global clinical scores, increased skin microrelief density, and induced elastic tissue repair in photoaged skin compared to excipient control in healthy female volunteers.
Experimental Dermatology, 2003Ascorbic acid 2-glucoside gel significantly reduced gingival melanin pigmentation after 4 weeks compared to placebo in 73 subjects with symmetric pigmentation.
Journal of Periodontology, 2009Topical application of VC-IP cream twice daily for 8 weeks reduces periorbital wrinkles in female subjects compared to a placebo cream.
Journal of Cosmetic Dermatology, 2022Topical copper tripeptide complex on CO2 laser-resurfaced skin caused no significant reduction in erythema or objective improvement in wrinkles compared to controls, but significantly increased patient satisfaction regarding overall skin quality.
Archives of Facial Plastic Surgery, 2006A novel regimen combining a hydroxy acid-based scrub and copper tripeptide serum significantly reduced adherent scalp flaking by 61.24%, increased hair density by 12.48%, increased hair thickness by 25.36%, and improved scalp skin hydration by 76.24% in adults with mild to moderate dandruff over 15 days.
Cureus, 2024The combination of Thermus thermophilus and Bacillus subtilis mixed-culture ferment extract and copper tripeptide-1 GHK-Cu reduced inflammatory cytokines, protected skin explants from UV-induced damage, and improved wrinkles and skin barrier conditions compared to individual components or controls.
Skin Research and Technology, 2026Daily topical acetyl hexapeptide-8 showed a trend toward a longer time until return to baseline Jankovic Blepharospasm Rating Scale scores compared to placebo (3.7 months vs. 3.0 months) in 24 patients with blepharospasm receiving botulinum toxin therapy.
European Journal of Neurology, 2013Argireline applied twice daily for 4 weeks achieved a total anti-wrinkle efficiency of 48.9% and notably reduced wrinkle depth compared to placebo in Chinese subjects.
Journal of Cosmetic and Laser Therapy, 2013Dissolving microneedles loaded with 3-O-ethyl ascorbic acid and acetyl hexapeptide-8 achieved higher cumulative transdermal delivery than aqueous solutions and significantly reduced photoaging signs while restoring oxidative balance in a UV/D-galactose-induced mouse model.
International Journal of Biological Macromolecules, 2026Repeated short-contact 70% glycolic acid peels provided superior results in atrophic acne scars compared to daily low-strength glycolic acid cream or placebo in 58 women over 24 weeks.
International Journal of Dermatology, 2000Serial glycolic acid peels combined with a modified Kligman formula significantly reduced facial PIH severity in Indian patients compared to the modified Kligman formula alone.
Dermatologic Surgery, 2017
Why other serums fit mature skin better
Caviar oil enhanced adipocyte differentiation in vitro, reduced MMP expression while increasing collagen and elastin formation ex vivo, and improved skin moisture, elasticity, and density in 102 participants over four weeks of Cavi Balm usage compared to baseline.
In Vivo, 2023Encapsulation of ferulic acid in phosphorylated rice starch enhanced its stability against heat and light and improved skin lightening, elasticity, smoothness, roughness, scaliness, and wrinkles compared to free ferulic acid in 16 volunteers over 1 month.
Molecules, 2022
Ingredients
Water, Glycerin, Isopropyl Palmitate, Cetearyl Alcohol, Glyceryl Stearate, Peg-100 Stearate, Butylene Glycol, Phosphatidylcholine, Tetrahexyldecyl Ascorbate, Dimethyl Mea, Acetyl Hexapeptide-8, Palmitoyl Tripeptide-1, Palmitoyl Tetrapeptide-3, Tyrosine, Glycolic Acid, Helianthus Annuus Seed Oil Sunflower Seed Oil, Magnesium Aspartate, Zinc Gluconate, Rosaminus Officinalis Leaf Extract Rosemary Leaf Extract, Copper Gluconate, Sodium Hyaluronate, Retinyl Palmitate, Echium Plantagineum Seed Oil, Hydrolyzed Myrtus Communis Leaf Extract, Copper Tripeptide-1, Dimethicone, Disodium Edta, Carbomer, Ceteareth-20, Cyclopentasiloxane, Caprylyl Glycol, Cyclohexasiloxane, Polysorbate 20, Zea Mays Oil, Phenoxyethanol, Sorbic Acid
Behind this fit score
Lovi calculates every fit score from the full ingredient list with brand-independent rules our dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update.
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Co-founder, Medical Director
Cosmetic chemist, cosmetologist, aesthetic products developer
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Co-founder, CEO and CTO
PhD in computer science, 3x US patent holder, ex-Google, ex-Yandex
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Dr. Sofía Perea Pérez, MD, MSc
Medical Board
Aesthetic medicine practitioner, MSc in Longevity and Anti-Aging Medicine
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Medical Board
Specialist dermatologist, MBBS, MD, IFAAD
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Medical Board
Cosmetic chemist, SCS, IFSCC member
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Medical Board, Medical Advisor
Dermatology MD
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Elina Nazarenko, MD
Medical Board
Dermatology and diagnostic consultant
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Victoria Derkova, MS
Medical Board
Cosmetic chemist, cosmetic development technologist
How does it fit your skin?
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