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Squalene

Rated by Lovi · Unbiased, science-based skincare AI trained on real user outcomes · How the Fit score works

Squalene

Squalene deeply softens the skin, fights daily damage, boosts moisture, and supports healthy tissue based on research models, while also visibly increasing skin thickness, collagen, and plumping compounds when paired with vitamin C. This gentle oil suits most skin types and is easily found in lightweight serums. It fits smoothly into your daily routine, working especially well alongside bio-placenta peptides, hexapeptide, and acetyl hexapeptide-3.

Molecules, 2009Scientific Reports, 2020

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Other squalene products

What to combine squalene with

IngredientTogetherHow to use them
Bio-placenta peptides Works well Use them together in the same routine, applying the squalene after your peptide product, because the squalene helps the peptides absorb better. Squalene and bio-placenta peptides
Hexapeptide Works well Use them together by applying the peptide serum first, because the squalene oil helps it sink in and locks in moisture. Squalene and hexapeptide
Acetyl hexapeptide-3 Works well Use them together in the same routine, applying the squalene after the peptide. Squalene and acetyl hexapeptide-3
Collagen peptide Works well Use them together by applying the collagen peptide first, because lipids help peptides sink in better. Squalene and collagen peptide
Copper peptide Works well Use them together in the same routine, applying the squalene after the copper peptide. Squalene and copper peptide
Hexapeptide-9 Works well Use them together in the same routine, applying the squalene after the hexapeptide-9, because the oil helps the peptide sink in better. Squalene and hexapeptide-9
Peptide-rich plasma Works well Use them together in the same routine, applying the squalene after your peptide product. Squalene and peptide-rich plasma
Triple peptide blend Works well Use them together in the same routine, applying your peptide blend first and following with your squalane. Squalene and triple peptide blend
Palmitoyl pentapeptide-4 Works well Use them together in the same routine, applying the squalane after the peptide. Squalene and palmitoyl pentapeptide-4
Palmitoyl tripeptide-1 Works well Use them together in the same routine, applying the peptide serum first and following with the squalane. Squalene and palmitoyl tripeptide-1

From the ingredient rules behind the "Works well with" and "Don't mix with" notes on every product in the Lovi app.

Questions and answers

What does squalene do for the skin?

Squalene acts as an emollient, antioxidant, hydrating agent, and antitumor substance for the skin based on scientific models.

Molecules, 2009

How do you use squalene?

Squalene acts as an emollient, antioxidant, hydrating agent, and antitumor substance based on studies. It helps the skin by providing these protective and moisturizing benefits.

Molecules, 2009

Should you use squalene in the morning or at night?

Squalene may be used both morning and night as a hydrating emollient and antioxidant.

Molecules, 2009

Can you use squalene every day?

Yes, you can use squalene every day because it acts as a gentle emollient and hydrating agent for the skin.

Molecules, 2009

Does squalene cause purging or irritation?

Squalene is unlikely to cause purging or irritation because it is a natural emollient that is well tolerated by the skin. It acts as a hydrating agent and antioxidant to support the skin barrier.

Molecules, 2009

Which skin types is squalene best for?

Squalene is best for dry skin as it acts as an emollient and hydrating agent.

Molecules, 2009

Can you use squalene with bio-placenta peptides?

Yes, you can use squalene with bio-placenta peptides in the same routine by applying the squalene after your peptide product, because the squalene helps the peptides absorb better.

Research on squalene

Behind this ingredient guide

Lovi checks every ingredient with brand-independent rules our dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update.

  • Nadia Kapleva, MS

    Nadia Kapleva, MS

    Co-founder, Medical Director

    Cosmetic chemist, cosmetologist, aesthetic products developer

  • Alexey Shagraev, PhD

    Alexey Shagraev, PhD

    Co-founder, CEO and CTO

    PhD in computer science, 3x US patent holder, ex-Google, ex-Yandex

  • Dr. Sofía Perea Pérez, MD, MSc

    Dr. Sofía Perea Pérez, MD, MSc

    Medical Board

    Aesthetic medicine practitioner, MSc in Longevity and Anti-Aging Medicine

  • Aishani Shah, MD

    Aishani Shah, MD

    Medical Board

    Specialist dermatologist, MBBS, MD, IFAAD

  • Asya Zubkova, MS

    Asya Zubkova, MS

    Medical Board

    Cosmetic chemist, SCS, IFSCC member

  • Hanna Kurets, MD

    Hanna Kurets, MD

    Medical Board, Medical Advisor

    Dermatology MD

  • Elina Nazarenko, MD

    Elina Nazarenko, MD

    Medical Board

    Dermatology and diagnostic consultant

  • Victoria Derkova, MS

    Victoria Derkova, MS

    Medical Board

    Cosmetic chemist, cosmetic development technologist

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