Magnesium and acetyl hexapeptide-3

Rated by Lovi · Unbiased, science-based skincare AI trained on real user outcomes · How the Fit score works

Keep them apart

Use them at different times of day, applying the peptide first and the magnesium later, because mixing them makes the peptide less effective. The magnesium can bind to the peptide and stop it from working properly on your skin. You can wait longer between applying them or use a product that already includes a stabilizer.

Magnesium products

Minimalist Vitamin B5 10% Moisturizer
Vichy Mineralizing Thermal Water €8.25

Acetyl hexapeptide-3 products

The Ordinary Multi-Peptide + Copper Peptides 1% Serum €30.95
The Ordinary Multi-Peptide + HA Serum €18.29
Medik8 Liquid Peptides €77.67
La Mer The Treatment Lotion
Rhode Peptide Glazing Fluid
The Ordinary Argireline Solution 10% €10.58
Good Molecules Super Peptide Serum €29.34
Clinique Smart Clinical Repair Wrinkle Correcting Serum €87.95
La Mer The Renewal Oil
Estée Lauder Micro Essence Treatment Lotion €87.98
The INKEY List Collagen Peptide Serum
La Mer The Eye Concentrate

Questions and answers

Can you use magnesium and acetyl hexapeptide-3 together?

Keep magnesium and acetyl hexapeptide-3 apart because unchelated metal ions like magnesium may complex with peptides and reduce their biological activity.

Which goes first, magnesium or acetyl hexapeptide-3?

Keep magnesium and acetyl hexapeptide-3 apart in your routine because they may complex together and reduce biological activity. Use them at separate times if you want to include both.

Are magnesium and acetyl hexapeptide-3 good for sensitive skin?

Keep magnesium and acetyl hexapeptide-3 apart in your routine because they may complex together and reduce their biological activity. Lovi gives this combination an Average fit rating.

Research on magnesium and acetyl hexapeptide-3

The anti-wrinkle efficacy of argireline, a synthetic hexapeptide, in Chinese subjects: a randomized, placebo-controlled study
Acetyl hexapeptide-3 · American Journal of Clinical Dermatology, 2013
Anti-Wrinkle Efficacy of Cross-Linked Hyaluronic Acid-Based Microneedle Patch with Acetyl Hexapeptide-8 and Epidermal Growth Factor on Korean Skin
Acetyl hexapeptide-3 · Annals of Dermatology, 2019
The efficacy study of the combination of tripeptide-10-citrulline and acetyl hexapeptide-3. A prospective, randomized controlled study
Acetyl hexapeptide-3 · Journal of Cosmetic Dermatology, 2017
The anti wrinkle efficacy of synthetic hexapeptide (Argireline) in Chinese Subjects
Acetyl hexapeptide-3 · Journal of Cosmetic and Laser Therapy, 2013

Behind this pairing advice

Lovi checks every pairing with brand-independent rules our dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update.

Nadia Kapleva, MS

Co-founder, Medical Director

Cosmetic chemist, cosmetologist, aesthetic products developer
Alexey Shagraev, PhD

Co-founder, CEO and CTO

PhD in computer science, 3x US patent holder, ex-Google, ex-Yandex
Dr. Sofía Perea Pérez, MD, MSc

Medical Board

Aesthetic medicine practitioner, MSc in Longevity and Anti-Aging Medicine
Aishani Shah, MD

Medical Board

Specialist dermatologist, MBBS, MD, IFAAD
Asya Zubkova, MS

Medical Board

Cosmetic chemist, SCS, IFSCC member
Hanna Kurets, MD

Medical Board, Medical Advisor

Dermatology MD
Elina Nazarenko, MD

Medical Board

Dermatology and diagnostic consultant
Victoria Derkova, MS

Medical Board

Cosmetic chemist, cosmetic development technologist

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