NIOD Modulating Glucosides for sensitive skin
Glucosides
Squalane
Superoxide Dismutase
Epigallocatechin Gallatyl Glucoside
Palmitoyl Tripeptide-8
High
- HighNormal Skin Fit
- HighEffectiveness
- HighSafety
A great choice for sensitive skin; a few serums fit it even better.
This fit is calculated for the concerns frequently associated with sensitive skin: redness, stinging, and reactions to new products. For scores and recommendations based on your full skin profile, including your 12D face scan results and any goals or preferences you have, please use the Lovi app.
Page built Nov 8, 2026How the Fit score works
Lovi Assistant explains
- Highly suitable for your normal skin, this formula leverages Bisabolol and Epigallocatechin Gallatyl Glucoside to effectively calm redness and irritation. These ingredients work synergistically to reduce inflammation and provide antioxidant protection, aligning perfectly with your primary concerns.
- The inclusion of Tasmannia Lanceolata Leaf Extract and Mirabilis Jalapa Callus Extract further enhances the soothing properties, offering additional benefits for your sensitive skin.
- The product demonstrates an excellent safety profile, free from harsh or prohibited ingredients and enriched with soothing components, ensuring no risk of irritation for your sensitive skin.
How to apply
- Use your serum in the PM routine, starting 3 times a week before building up to daily use if your skin is happy.
- Apply the serum after cleansing and toning, but before putting on your moisturizer for the best results.
- Gently press 2-3 drops of the serum into your skin and wait a minute ⏱ for it to soak in.
- Since your skin is sensitive and easily irritated, apply the serum on completely dry skin to help keep it calm.
- Always do a patch test before your first use and avoid getting the serum too close to your eyes .
People Say
★4.8Overall rating based on 400+ reviewsThis serum is highly praised for its ability to calm sensitive, reactive, and irritated skin, with users frequently reporting significant improvements in redness, stinging, and compromised skin barriers. It is a popular choice for those recovering from aesthetic treatments or harsh active ingredients. Some users with normal skin may find the benefits less noticeable or the texture slightly heavy.
Highlights
Calms sensitive skin Mostly Mentioned
- “Like medicine to irritated skin.”
- “Great for sensitive, reactive skin.”
- “Helps quiet sensations of stinging and itching.”
Reduces skin redness Often Mentioned
- “Visibly reduced redness for a more even tone.”
- “Calms redness and stinging.”
- “It really did wonders in soothing skin and reducing redness.”
Buffers active irritation Sometimes Noted
- “Helps minimise the side effects of retinoids.”
- “Buffers retinoid/acid irritation.”
- “Reason my skin had been so calm while I was on Roaccutane.”
Strengthens skin barrier Sometimes Noted
- “Saved my skin barrier from beyond hope.”
- “Strengthens skin barrier integrity over time.”
- “Especially helpful when my barrier is compromised.”
Inconvenient packaging Sometimes Noted
- “Dropper bottle is messy to use.”
- “Not my favorite type of packaging.”
- “Why doesn't it come with a pump?”
Subtle for normal skin Sometimes Noted
- “If you have normal skin, benefits may not be apparent.”
- “I did not notice any improvement.”
Can cause breakouts Rarely Noted
- “It broke me out almost instantly.”
- “Heavy going on my face.”
Unappealing scent Rarely Noted
- “Strong nutty scent.”
- “A bit like paint.”
- “Has a bit of a medicinal smell.”
Sources: lovi.care, niod.com, skinsort.com, dermapproved.com, drrachelho.com, daniellesbeautyblog.com, and more
Questions and answers
What makes Modulating Glucosides a great fit for sensitive skin?
This treatment is a great fit because it uses ingredients like bisabolol and soothing plant extracts to calm redness and irritation on sensitive skin. It also has a safe formula that is free from harsh ingredients, ensuring it is very unlikely to cause any further irritation.
Which ingredients make this serum a good fit for sensitive skin?
This serum is a great fit for sensitive skin because it uses bisabolol and epigallocatechin gallatyl glucoside to calm redness and irritation. Tasmannia lanceolata leaf extract and mirabilis jalapa callus extract further enhance these soothing properties to keep your skin comfortable and protected.
What do Glucosides do for sensitive skin?
Glucosides help cleanse or carry ingredients for sensitive skin while showing an acceptable safety profile with little to no irritation. Clinical studies on human volunteers show that formulas using alkyl polyglucoside emulsifiers provide good skin hydration and are well tolerated by normal and irritated skin.
Vojnosanitetski Pregled, 2016Pharmaceutical Development and Technology, 2021
What does Squalane do for sensitive skin?
Squalane helps calm sensitive skin by defending against everyday irritation and keeping it smooth and soft. It is unlikely to cause irritation and supports your skin barrier so it stays comfortable and hydrated.
Where does this serum go in a skincare routine for sensitive skin?
This treatment goes in the evening routine after your cleansing and toning steps, which helps keep things simple and safe for sensitive skin. This gentle formula is unlikely to cause irritation and works to calm redness.
Can I use this serum with retinol, and in what order?
You can use this treatment alongside retinol by applying it first to calm the skin before layering your retinol, as it is very gentle and well-tolerated. This helps keep your skin comfortable and minimizes any redness or irritation that strong ingredients might cause.
How often should I use this serum?
This serum is a great fit for your sensitive skin and is used in the evening as part of your routine. It is unlikely to cause irritation and helps calm redness because it is free from harsh ingredients and enriched with soothing components.
Can this serum clog pores, cause breakouts or purging for sensitive skin?
This serum is unlikely to cause breakouts or clog pores on sensitive skin because it has a very safe formula free from harsh ingredients and is enriched with calming components. Reviewers only rarely mention breakouts from using it.
Is this serum fragrance-free and alcohol-free?
It has no drying alcohol and contains fragrance (benzyl alcohol).
What the research says
Squalane at 0.005-0.015% counteracts UVA-induced oxidative stress, inflammation, and collagen metabolism inhibition while stimulating fibroblast migration in human dermal fibroblasts.
Molecules, 2025Plant-derived squalane protected human dermal fibroblasts against UVA-induced damage by counteracting ROS formation, suppressing apoptosis-related proteins p53, caspase-3, caspase-9, and PARP, and restoring the pro-survival p-Akt/mTOR pathway.
Antioxidants, 2025Topical application of TAT-SOD significantly suppresses UVB-induced erythema formation, blood flow rise, and apoptotic sunburn cell formation in human volunteers compared to a vehicle control.
European Journal of Pharmaceutics and Biopharmaceutics, 2016Topical treatment with the synthetic SOD/catalase mimetic EUK-134 reduced lipid peroxide levels both at baseline on non-irradiated human skin and at the surface of UVA-exposed skin when applied before or after irradiation, compared to controls.
International Journal of Cosmetic Science, 2004Topical superoxide dismutase formulations maintained physical stability and enzymatic activity for 6 months at 4 and 30 degrees C, and effectively inhibited UVB-induced skin erythema for 48 hours, whereas formulations combined with alpha-tocopherol were unstable.
European Journal of Pharmaceutics and Biopharmaceutics, 2007Topical green tea extract significantly improved clinical symptoms, tear breakup times, and meibomian gland health compared to standard treatment in patients with dry eye and Meibomian Gland Dysfunction.
Journal of Clinical and Diagnostic Research, 2017Topical low-dose green tea extract reduces UVB-induced p53 expression and apoptosis in human skin keratinocytes compared to placebo.
Experimental Dermatology, 2009An anti-acne hydrogel containing Aloe barbadensis, Garcinia mangostana, and Camellia sinensis extracts showed superior antiacne and antiblotch activities compared to 1% clindamycin gel in sixty subjects with mild-moderate acne.
Clinical, Cosmetic and Investigational Dermatology, 2019
Ingredients
Water, Squalane, Isodecyl Neopentanoate, Glycerin, Caprylic Capric Triglyceride, Pentylene Glycol, Propanediol, Hexyldecanol, Bisabolol, Butylene Glycol, Epigallocatechin Gallatyl Glucoside, Rosmarinyl Glucoside, Caffeyl Glucoside, Gallyl Glucoside, Tetrasodium Tetracarboxymethyl Naringeninchalcone, Hydroxymethoxyphenyl Decanone, 4-T-Butylcyclohexanol, Cetylhydroxyproline Palmitamide, Hydroxyphenyl Propamidobenzoic Acid, Palmitoyl Tripeptide-8, Superoxide Dismutase, Sodium Pca, Pca, Arginine, Glycine, Alanine, Serine, Valine, Isoleucine, Proline, Threonine, Histidine, Phenylalanine, Aspartic Acid, Sodium Lactate, Mirabilis Jalapa Callus Extract, Tasmannia Lanceolata Leaf Extract Fruit, Zingiber Officinale Root Extract, Curculigo Orchioides Root Extract, Isochrysis Galbana Extract, Brassica Campestris Sterols, Stearic Acid, Dextran, Isoceteth-20, Polyacrylate Crosspolymer-6, Xanthan Gum, Tocopherol, Propyl Gallate, Tromethamine, Dehydroacetic Acid, 1,2-Hexanediol, Benzyl Alcohol, Phenoxyethanol, Caprylyl Glycol
Behind this fit score
Lovi calculates every fit score from the full ingredient list with brand-independent rules our dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update.
-
Co-founder, Medical Director
Cosmetic chemist, cosmetologist, aesthetic products developer
-
Co-founder, CEO and CTO
PhD in computer science, 3x US patent holder, ex-Google, ex-Yandex
-
Dr. Sofía Perea Pérez, MD, MSc
Medical Board
Aesthetic medicine practitioner, MSc in Longevity and Anti-Aging Medicine
-
Medical Board
Specialist dermatologist, MBBS, MD, IFAAD
-
Medical Board
Cosmetic chemist, SCS, IFSCC member
-
Medical Board, Medical Advisor
Dermatology MD
-
Elina Nazarenko, MD
Medical Board
Dermatology and diagnostic consultant
-
Victoria Derkova, MS
Medical Board
Cosmetic chemist, cosmetic development technologist
How does it fit your skin?
Scan your face, then any product: Lovi shows how well it fits you and what fits even better.