Allies of Skin Retinal & Peptides Repair Night Cream for mature skin

How to apply

Questions and answers

What the research says

• Topical application of an argan oil NLC-based hydrogel formulation increased skin hydration in healthy volunteers over a one-month period through a synergistic effect of NLC occlusion and argan oil hydration.

  International Journal of Nanomedicine, 2014

• Topical post-laser application of human adipocyte-derived mesenchymal stem cell media combined with niacinamide significantly improved wrinkle index, melanin index, patient satisfaction, and investigator esthetic improvement scores compared to vehicle cream in patients with aging skin.

  Journal of Cosmetic Dermatology, 2021

• A combination cream of stimu-tex AS and saccharide isomerate reduced erythema, increased skin capacitance, and reduced transepidermal water loss compared to placebo in 20 subjects after fractional CO2 laser procedure without causing serious adverse events.

  Lasers in Medical Science, 2025

• Topical treatment of nicotinamide, alone or in combination with other active ingredients, reduces the progression of skin aging and hyperpigmentation in clinical trials while being well tolerated.

  Antioxidants, 2021

• Twice daily application of retinaldehyde 0.1% and 0.05% creams for 3 months improved skin texture and hydration and reduced transepidermal water loss in 40 female Korean volunteers, with only the 0.1% cream significantly improving the melanin index.

  Journal of Cosmetic Dermatology, 2018

• Topical retinaldehyde demonstrated significant antibacterial activity against gram-positive bacteria both in vitro and in vivo, leading to decreased bacterial counts without inducing resistance.

  Dermatology, 2002

• Topical 0.05% retinaldehyde applied over 1 year significantly increased epidermal thickness of the temple and cutaneous elasticity compared to an emollient control group in 40 aging skin patients.

  Dermatology, 1999

• A multi-modal methodology combining MALDI-MSI, in vivo RCM, echography, and histology revealed age-related decreases in extracellular matrix and epidermal-dermal junction proteins and undulation depth, while a blend of palmitoyl oligopeptide and palmitoyl tetrapeptide-7 improved subepidermal low-echogenic band thickness, density, and extracellular matrix structure compared to placebo.

  Journal of Cosmetic Dermatology, 2015

• Palmitoyl tetrapeptide-7, acetyl hexapeptide-8, palmitoyl tripeptide-1, and palmitoyl tetrapeptide-10 significantly increased type III collagen levels in human dermal fibroblasts following UV exposure, with their combination demonstrating a greater effect in vitro and enhancing type I, III, and IV collagen levels in ex vivo skin tissues compared to individual components.

  International Journal of Cosmetic Science, 2026

• Topical nicotinamide prevented solar-simulated UV-induced immunosuppression in healthy volunteers, and men experienced immunosuppression at solar-simulated UV doses three times lower than those required for women.

  The Journal of Investigative Dermatology, 2008

• Topical 5% niacinamide applied twice daily for 12 weeks reduced fine lines and wrinkles, hyperpigmented spots, red blotchiness, and skin sallowness, and improved skin elasticity compared to vehicle control in 50 female white subjects with facial photoaging.

  Dermatologic Surgery, 2005

• Topical 2% niacinamide significantly decreased sebum excretion rate in Japanese individuals and casual sebum levels in Caucasian individuals compared to placebo or baseline.

  Journal of Cosmetic and Laser Therapy, 2006

• Glutathione amino acid precursors effectively increase cellular glutathione levels, reducing oxidative stress, ATP depletion, and DNA damage in human keratinocytes, clinical subjects, and ex vivo skin compared to controls.

  Journal of the European Academy of Dermatology and Venereology, 2024

• Topical oxidized glutathione significantly decreases the skin melanin index and improves moisture content, smoothness, wrinkle formation, and elasticity compared to placebo in healthy women.

  Clinical, Cosmetic and Investigational Dermatology, 2014

• Topical glutathione improves hyperpigmentation, reduces ultraviolet-induced erythema and wrinkles, decreases transepidermal water loss, and enhances antioxidant capacity.

  The Journal of Clinical and Aesthetic Dermatology, 2025

• A novel formulation of hydroxyphenoxy propionic acid, ellagic acid, yeast extract, and salicylic acid demonstrated parity in improving pigmentation, skin tone, spot intensity, and spot size compared to standard prescription 4% hydroquinone and 0.025% tretinoin in 82 subjects, with superior tolerability.

  Journal of Cosmetic Dermatology, 2013

• A topical product containing 0.5% ellagic acid and 0.1% salicylic acid demonstrated comparable tolerance and efficacy in reducing hyperpigmentation and dark spots in fifty-four multiethnic subjects over 12 weeks when compared against a benchmark prescription 4% hydroquinone product.

  Journal of Drugs in Dermatology, 2013

• Platycarya strobilacea fruit extract and its isolated ellagic acid derivatives demonstrated anti-wrinkle and antiaging potential by scavenging free radicals, inhibiting elastase, reducing MMP-1, and increasing type I collagen synthesis in human fibroblast cells, with clinical testing showing significant improvements compared to placebo.

  Journal of Cosmetic Science, 2010

Why other moisturizers fit mature skin better

• Combining oral and topical astaxanthin in 30 healthy females improved skin wrinkles, age spots, elasticity, texture, and moisture, while 6 mg daily oral supplementation in 36 healthy males improved crow's feet wrinkles, elasticity, and transepidermal water loss.

  Acta Biochimica Polonica, 2012

• Adenosine-loaded dissolving microneedle patches showed similar or better efficacy on skin wrinkles, dermal density, elasticity, and hydration compared to adenosine cream in 22 female subjects.

  International Journal of Cosmetic Science, 2018

• Treatment with cross-linked hyaluronic acid-based microneedle patches combined with acetyl hexapeptide-8 or epidermal growth factor significantly improved wrinkles and skin hydration compared to the patch alone in Korean females over 29 days.

  Annals of Dermatology, 2019

Ingredients

Water, Glycerin, Caprylic Capric Triglyceride, Propanediol, Argania Spinosa Kernel Oil, Sodium Acrylates Copolymer, Hydrolyzed Candida Saitoana Extract, Sodium Stearoyl Glutamate, Albizia Julibrissin Bark Extract, Dimethyl Isosorbide, Galactoarabinan, Palmitoyl Tetrapeptide-7, Palmitoyl Tripeptide-1, Caprooyl Tetrapeptide-3, Cassia Angustifolia Polysaccharide Seed, Sodium Hyaluronate, Oxycoccus Palustris Seed Oil Arctic Cranberry Seed Oil, Rubus Chamaemorus Berry Seed Oil Cloud Berry Seed Oil, Niacinamide, Citrus Aurantium Dulcis Callus Culture Extract, Retinal Retinaldehyde, Pterostilbene, Ellagic Acid, Phenyl T-Butylnitrone Spin Trap, Ergothioneine, Glutathione, Mirabilis Jalapa Stem Extract Flower Leaf, N-Hydroxysuccinimide, Chrysin, Glutamylamidoethyl Imidazole, Lonicera Caprifolium Flower Extract Honeysuckle Flower Extract, Lonicera Japonica Flower Extract Honeysuckle Flower Extract, Lavandula Hybrida Oil Lavendin Oil, Pentylene Glycol, Butylene Glycol, Cyclodextrin, Caprylyl Glycol, Steareth-20, Citric Acid, Xanthan Gum, Dextran, Acetyl Tributyl Citrate, Potassium Sorbate, Phenoxyethanol, Geraniol, Limonene, Linalool

Behind this fit score

Lovi calculates every fit score from the full ingredient list with brand-independent rules our dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update.