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Ergothioneine

Rated by Lovi · Unbiased, science-based skincare AI trained on real user outcomes · How the Fit score works

Ergothioneine

Ergothioneine gently helps the skin by neutralizing everyday stress, shielding against ultraviolet damage, and smoothing away redness, dryness, flaking, and fine lines while supporting lasting moisture, firmness, and natural barrier strength. This thoughtful ingredient suits almost all skin types and is commonly found in nourishing serums designed for daily care. Because it layers easily, ergothioneine fits seamlessly into any existing skincare routine.

Free Radical Biology & Medicine, 2015ACS Applied Materials & Interfaces, 2024International Journal of Cosmetic Science, 2025

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What reviewers say about popular ergothioneine products

The highlight reviewers mention most for each popular ergothioneine product on Lovi.

Questions and answers

What does ergothioneine do for the skin?

Ergothioneine helps protect the skin against UV and radiation damage by fighting free radicals, reducing oxidative stress, and supporting antioxidant defenses. It also helps improve skin hydration, elasticity, and barrier function while decreasing redness and signs of aging.

Free Radical Biology & Medicine, 2015ACS Applied Materials & Interfaces, 2024

How do you use ergothioneine?

Ergothioneine is used daily in targeted skincare regimens and dressings to help protect against skin damage from UV rays and treatments, while improving skin hydration and elasticity.

Free Radical Biology & Medicine, 2015ACS Applied Materials & Interfaces, 2024

Should you use ergothioneine in the morning or at night?

Ergothioneine helps protect skin from UV and oxidative damage when used as part of your routine. Studies show it supports antioxidant defenses and helps improve skin elasticity and hydration over time.

Free Radical Biology & Medicine, 2015Frontiers in Nutrition, 2026

Can you use ergothioneine every day?

Yes, you can use ergothioneine every day as it helps protect against skin damage and oxidative stress. Studies show it supports skin health, hydration, and elasticity when used regularly.

Free Radical Biology & Medicine, 2015ACS Applied Materials & Interfaces, 2024

Does ergothioneine cause purging or irritation?

Ergothioneine is unlikely to cause purging or irritation as it is known for its protective, antioxidant, and anti-inflammatory properties that help defend the skin against damage and oxidative stress.

Free Radical Biology & Medicine, 2015ACS Applied Materials & Interfaces, 2024

Which skin types is ergothioneine best for?

Ergothioneine is best for skin types dealing with environmental damage and aging, as it helps protect against UV and oxidative stress. It is found in popular products like The Ordinary Retinal 0.2% Emulsion, Skinbetter Science Alto Advanced Defense and Repair Serum, and Paula's Choice 25% Vitamin C + Glutathione Clinical Serum.

Free Radical Biology & Medicine, 2015Frontiers in Nutrition, 2026

Research on ergothioneine

Behind this ingredient guide

Lovi checks every ingredient with brand-independent rules our dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update.

  • Nadia Kapleva, MS

    Nadia Kapleva, MS

    Co-founder, Medical Director

    Cosmetic chemist, cosmetologist, aesthetic products developer

  • Alexey Shagraev, PhD

    Alexey Shagraev, PhD

    Co-founder, CEO and CTO

    PhD in computer science, 3x US patent holder, ex-Google, ex-Yandex

  • Dr. Sofía Perea Pérez, MD, MSc

    Dr. Sofía Perea Pérez, MD, MSc

    Medical Board

    Aesthetic medicine practitioner, MSc in Longevity and Anti-Aging Medicine

  • Aishani Shah, MD

    Aishani Shah, MD

    Medical Board

    Specialist dermatologist, MBBS, MD, IFAAD

  • Asya Zubkova, MS

    Asya Zubkova, MS

    Medical Board

    Cosmetic chemist, SCS, IFSCC member

  • Hanna Kurets, MD

    Hanna Kurets, MD

    Medical Board, Medical Advisor

    Dermatology MD

  • Elina Nazarenko, MD

    Elina Nazarenko, MD

    Medical Board

    Dermatology and diagnostic consultant

  • Victoria Derkova, MS

    Victoria Derkova, MS

    Medical Board

    Cosmetic chemist, cosmetic development technologist

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