Galderma vs Sesderma
Galderma and Sesderma are distinguished skincare houses originating from Switzerland and Spain, respectively. The Swiss brand centers on targeted serums formulated for oily and acne-prone skin, with standout options like the Epiduo Gel and the Benzac AC series. Meanwhile, the Spanish brand is beloved for advanced serums and engineered formulas that suit sensitive, hyperpigmented, and aging skin types, highlighted by the Azelac RU Serum. Ultimately, both differ in their regional heritage, founding eras, and precise dermatological focus.
Galderma is a Swiss skincare brand founded in 1981 and owned by Galderma Group AG.
Sesderma is a Spanish skincare brand founded in 1989 and owned by Grupo Sesderma since 2026.
skinexpert.sesderma.comsesderma.com
This page compares some of the most popular Galderma and Sesderma products; for every product of both brands, with a fit score for your own skin, use the Lovi app.
Popular Galderma vs Sesderma products
Galderma vs Sesderma serums and treatments
Questions and answers
Galderma or Sesderma: which is better?
Galderma is best for oily and acne-prone skin with its fragrance-free serums, while Sesderma is a better choice for combination skin and dark spots, though its serum contains fragrance. Topical benzoyl peroxide helps clear acne, and azelaic acid helps manage acne-prone skin.
The Cochrane Database of Systematic Reviews, 2020Pharmaceutics, 2021
What is the difference between Galderma and Sesderma?
Galderma is best for oily and acne-prone skin with fragrance-free serums like Epiduo Gel, whereas Sesderma offers Azelac RU Serum for dark spots and acne-prone skin but includes fragrance. Galderma products on this page often cause severe dryness and irritation.
The Cochrane Database of Systematic Reviews, 2020Pharmaceutics, 2021
Which is more affordable, Galderma or Sesderma?
The page does not provide pricing information for Galderma or Sesderma, so it is not possible to determine which brand is more affordable.
Which causes fewer breakouts, Galderma or Sesderma?
Galderma is the better choice for acne because the products on this page are effective acne-clearing serums that fit acne-prone and oily skin with a High Lovi fit level.
How do the founding years and countries of origin compare between Galderma and Sesderma?
Galderma was founded in 1981 in Switzerland, whereas Sesderma was founded in 1989 in Spain.
Which brand has more fragrance-free products listed on the page, Galderma or Sesderma?
Galderma has more fragrance-free products listed on the page, as every product from Galderma lists no fragrance in its ingredients while Sesderma has none listed as fragrance-free.
What are the main drawbacks reported by reviewers regarding Galderma products?
Reviewers mostly mention that Galderma products can cause severe dryness, peeling, irritation, and discomfort.
Research behind their key ingredients
The effect of niacinamide on reducing cutaneous pigmentation and suppression of melanosome transfer
Molecular basis of retinol anti-ageing properties in naturally aged human skin in vivo
Behind this comparison
Lovi compares products by their fit scores, calculated from the full ingredient list with brand-independent rules our dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update.
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Co-founder, Medical Director
Cosmetic chemist, cosmetologist, aesthetic products developer
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Co-founder, CEO and CTO
PhD in computer science, 3x US patent holder, ex-Google, ex-Yandex
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Dr. Sofía Perea Pérez, MD, MSc
Medical Board
Aesthetic medicine practitioner, MSc in Longevity and Anti-Aging Medicine
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Medical Board
Specialist dermatologist, MBBS, MD, IFAAD
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Medical Board
Cosmetic chemist, SCS, IFSCC member
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Medical Board, Medical Advisor
Dermatology MD
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Elina Nazarenko, MD
Medical Board
Dermatology and diagnostic consultant
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Victoria Derkova, MS
Medical Board
Cosmetic chemist, cosmetic development technologist
How does it fit your skin?
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