Estée Lauder DayWear Multi-Protection Anti-Oxidant 24H-Moisture Creme SPF 15 for combination skin

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Questions and answers

What the research says

• A single application of a moisturizing fluid containing hyaluronic acid 1%, glycerin 5%, and Centella asiatica stem cells extract significantly increased skin hydration by 29% and reduced transepidermal water loss at 24 hours compared to baseline and an untreated control site in twenty healthy women.

  Clinical, Cosmetic and Investigational Dermatology, 2017

• A dermo-cosmetic formula containing 2% enoxolone significantly reduced erythema at 24 hours and pain at 30 minutes following non-ablative fractional laser treatment in 10 healthy subjects compared to a moisturizer control.

  Journal of Cosmetic Dermatology, 2024

• Sodium trehalose sulfate decreased transepidermal water loss and increased stratum corneum water content in participants with low stratum corneum water content when applied for 4 weeks compared to placebo.

  Skin Research and Technology, 2024

• Encapsulation of ethylhexyl methoxycinnamate and butyl methoxydibenzoylmethane in lipid microparticles significantly reduced their in vivo human skin penetration compared to nonencapsulated filters.

  Skin Pharmacology and Physiology, 2011

• Microencapsulation of the BMDBM/HP-beta-CD complex in lipid microparticles significantly decreased the percutaneous penetration of the UV filter into the stratum corneum of human volunteers compared to the non-encapsulated sunscreen agent.

  Journal of Pharmaceutical and Biomedical Analysis, 2011

• Following human skin application of an O/W emulsion containing 2% BMDBM loaded in lipospheres, 15% of the sunscreen accumulated in the uppermost layers of the stratum corneum without remarkably modifying skin permeation compared to unencapsulated sunscreen.

  Skin Pharmacology and Physiology, 2008

• Simulated real-life dermal sunscreen exposure in twenty human volunteers leads to the systemic bioavailability and urinary excretion of the UV filter 2-ethylhexyl salicylate and its metabolite, reaching concentration peaks at 7 to 8 hours with 70-80% of overall excretion within 24 hours.

  Archives of Toxicology, 2019

• The application of a sunscreen formulation containing ethylhexyl methoxycinnamate, ethylhexyl salicylate, methyl anthranilate, and octocrylene does not significantly affect critical acne-related species such as Cutibacterium acnes and Staphylococcus epidermidis, refuting the induction of facial dysbiosis in men.

  Archives of Dermatological Research, 2024

• Controlled single dermal exposure to an EHS-containing sunscreen in three volunteers resulted in delayed systemic resorption with elimination half-lives between 6.6 and 9.7 hours, where the parent compound EHS occurred as the dominant urinary parameter.

  Archives of Toxicology, 2024

• A toner with 6% guava extract significantly reduced skin oiliness on the forehead and nose compared to the base toner in 21 volunteers over 28 days.

  Journal of Cosmetic Dermatology, 2019

• Pre-incubation with guava crude extract significantly decreased apoptotic and dead cells and markers of oxidative damage while improving antioxidant enzyme activity in human dermal fibroblasts subjected to AAPH-mediated oxidative stress, compared to cells subjected to stress without prior pre-incubation.

  Plant Foods for Human Nutrition, 2018

• Topical application of 5% vitamin C cream significantly improved global clinical scores, increased skin microrelief density, and induced elastic tissue repair in photoaged skin compared to excipient control in healthy female volunteers.

  Experimental Dermatology, 2003

• Ascorbic acid 2-glucoside gel significantly reduced gingival melanin pigmentation after 4 weeks compared to placebo in 73 subjects with symmetric pigmentation.

  Journal of Periodontology, 2009

• Topical application of VC-IP cream twice daily for 8 weeks reduces periorbital wrinkles in female subjects compared to a placebo cream.

  Journal of Cosmetic Dermatology, 2022

• Squalane at 0.005-0.015% counteracts UVA-induced oxidative stress, inflammation, and collagen metabolism inhibition while stimulating fibroblast migration in human dermal fibroblasts.

  Molecules, 2025

• Plant-derived squalane protected human dermal fibroblasts against UVA-induced damage by counteracting ROS formation, suppressing apoptosis-related proteins p53, caspase-3, caspase-9, and PARP, and restoring the pro-survival p-Akt/mTOR pathway.

  Antioxidants, 2025

Ingredients

Avobenzone, Octisalate, Homosalate, Water, Dimethicone, Butyloctyl Salicylate, Butylene Glycol, Polyester-8, Cetyl Ricinoleate, Steareth-21, Steareth-2, Di-C12-15 Alkyl Fumarate, Caprylic Capric Myristic Stearic Triglyceride, Polysilicone-11, Psidium Guajava Fruit Extract, Gentiana Lutea Root Extract, Polygonum Cuspidatum Root Extract, Stearyl Alcohol, Hordeum Vulgare Extract Extrait Dorge Extract, Laminaria Ochroleuca Extract, Rosamarinus Officinalis Leaf Extract Rosemary Leaf Extract, Wheat Extract Germ Extract, Artemia Extract, Fumaria Officinalis Stem Extract Flower Leaf, Caffeine, Pentylene Glycol, Lemon Fruit Extract, Hydrolyzed Rice Extract, Vitis Vinifera Seed Extract Grape Seed Extract, Hydrolyzed Rice Bran Extract, Lauryl Peg-9 Polydimethylsiloxyethyl Dimethicone, Thermus Thermophillus Ferment, Behenyl Alcohol, Acrylic Acid Vp Crosspolymer, Triacontanyl Pvp, Glycerin, C12-15 Alkyl Benzoate, Linoleic Acid, Cholesterol, Squalane, Sodium Pca, 1,2-Hexanediol, Urea, Caprylic Capric Triglyceride, Dipropylene Glycol Dibenzoate, Tocopheryl Acetate, Acrylamide Sodium Acryloyldimethyltaurate Copolymer, Tetrahexyldecyl Ascorbate, Sodium Hyaluronate, Ergothioneine, Isohexadecane, Ppg-15 Stearyl Ether Benzoate, Glycyrrhetinic Acid, Trehalose, Polyquaternium-51, Polysorbate 80, Lecithin, Hydrogenated Lecithin, Fumaric Acid, Palmitoyl Hydroxypropyltrimonium Amylopectin Gycerin Crosspolymer, Caprylyl Glycol, Cyclodextrin, Sodium Hydroxide, Nordihydroguaiaretic Acid, Sodium Chloride, Ascorbyl Tocopheryl Maleate, Parfum, Citric Acid, Ethylbisiminomethylguaiacol Manganese Chloride, Pentaerythrityl Tetra-Di-T-Butyl Hydroxyhydrocinnamate, Disodium Edta, Bht, Sodium Dehydroacetate, Phenoxyethanol, Blue 1 Ci 42090, Yellow 5 Ci 19140, Chromium Hydroxide Green Ci 77289

Behind this fit score

Lovi calculates every fit score from the full ingredient list with brand-independent rules our dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update.