Good Molecules Gentle Retinol Cream for mature skin

How to apply

Questions and answers

What the research says

• Topical bakuchiol 0.5% applied twice daily compared with retinol 0.5% applied daily significantly decreased wrinkle surface area and hyperpigmentation with no statistical difference between the compounds in 44 patients over 12 weeks, while retinol users reported more facial skin scaling and stinging.

  The British Journal of Dermatology, 2019

• A single application of a moisturizing fluid containing hyaluronic acid 1%, glycerin 5%, and Centella asiatica stem cells extract significantly increased skin hydration by 29% and reduced transepidermal water loss at 24 hours compared to baseline and an untreated control site in twenty healthy women.

  Clinical, Cosmetic and Investigational Dermatology, 2017

• Topical gel containing chitosan, 0.2% chlorhexidine, allantoin and dexpanthenol did not improve postoperative comfort regarding swelling and pain, but improved the wound's aesthetic appearance following impacted lower third molar extraction compared to no gel.

  Medicina Oral, Patologia Oral Y Cirugia Bucal, 2016

• Topical 0.4% retinol significantly increased epidermal thickness, dermal vascularity, and extracellular matrix production by stimulating keratinocyte proliferation, endothelial cell proliferation, and fibroblast activation in naturally aged human skin compared to vehicle.

  International Journal of Cosmetic Science, 2017

• Silicone particles encapsulating retinol increased its half-life by 9-fold and yielded 12-23% lower skin irritation in human subjects compared to Microsponge particles while maintaining biological activity.

  Journal of Controlled Release, 2018

• Topical stabilized retinol treatment induced HAS gene expression and increased hyaluronic acid production in human skin in vitro, ex vivo, and in vivo compared to vehicle.

  Archives of Dermatological Research, 2017

• A dermocosmetic containing bakuchiol, Ginkgo biloba extract, and mannitol improves inflammatory lesions, Investigator Global Assessment, and seborrhea intensity when added to adapalene 0.1% gel in patients with acne vulgaris.

  Clinical, Cosmetic and Investigational Dermatology, 2015

• Topical application of a serum containing supramolecular Bakuchiol and Terminalia chebula extract significantly improved barrier function, reduced redness and sensitivity, and improved wrinkles and elasticity in 34 Chinese subjects with sensitive skin after 28 days.

  Health Science Reports, 2025

• Bakuchiol functions as an anti-aging compound through retinol-like regulation of gene expression, producing significant improvements in lines, wrinkles, pigmentation, elasticity, firmness, and photo-damage after 12 weeks of twice-a-day facial application without usual retinol therapy-associated undesirable effects.

  International Journal of Cosmetic Science, 2014

• The emollient V0034CR significantly reduced TEWL compared to vehicle and vehicle plus glycerol, and significantly increased corneometry scores compared to vehicle and vehicle plus petrolatum in healthy volunteers with dry skin, demonstrating combined barrier function improvement from petrolatum and hydration improvement from glycerol.

  Journal of Cosmetic Dermatology, 2020

• Ten days of treatment with a cream containing 20% glycerin significantly increased skin hydration measured by corneometer values in 17 healthy volunteers compared to a placebo cream, but showed no influence on transepidermal water loss or skin sensitivity to an irritating surfactant.

  International Journal of Cosmetic Science, 2001

• Niacinamide/glycerin body moisturizers provided better rapid and prolonged improvement of cosmetic xerosis through functional improvement of stratum corneum barrier function compared to no treatment and conventional moisturizers in female subjects.

  Journal of Drugs in Dermatology, 2012

• An Acmella oleracea extract-loaded glycolipid emulsion serum applied topically demonstrated safety with no ocular irritation or systemic dermal absorption, alongside significant improvements in facial skin hydration, smoothness, and reductions in roughness, scaliness, and wrinkles.

  International Journal of Cosmetic Science, 2025

• A novel formulation containing supramolecular retinol plus acmella oleracea extract significantly reduced dark circles by 13.8% in melanin index, decreased fine wrinkles, and increased skin firmness by 13.0% in 33 Chinese urban women after 6 weeks of use.

  Journal of Cosmetic Dermatology, 2022

• The optimized squalane-based spilanthol emulsion achieved a maximum skin retention of 118.71 μg/g and restored skin hydroxyproline content to 23.99 μg/g, outperforming positive and negative groups due to high drug release and miscibility driven by weak Van der Waals interactions.

  AAPS PharmSciTech, 2019

• Grapeseed oil-loaded dermocosmetic nanoemulgel applied on the cheeks of healthy volunteers significantly reduced skin melanin, erythema, sebum production, and pores while increasing moisture and elasticity compared to a placebo.

  Journal of Cosmetic Dermatology, 2022

• Topical treatment with cranberry oil and grape oil improved wound healing in rats, with cranberry oil showing an 88.1% wound area reduction and grape oil showing 84.6% compared to 74.1% in controls and 78.4% in the mupirocin standard group on day 13.

  Phytotherapy Research, 2011

• An ionic liquid-based grapeseed oil emulsion increased transdermal penetration by 4.63-fold and improved skin hydration, firmness, elasticity, and facial wrinkles after 28 days of continuous use compared to ordinary emulsion.

  Pharmaceuticals, 2024

Ingredients

Water, C13-16 Isoparaffin, Glycerin, Diheptyl Succinate, Heptyl Undecylenate, 1,2-Hexanediol, Ammonium Acryloyldimethyltaurate Vp Copolymer, Polyglyceryl-10 Oleate, Propanediol, Vitis Vinifera Seed Oil Grape Seed Oil, Caprylic Capric Triglyceride, Bakuchiol, Tocopherol, Acmella Oleracea Extract, Butylene Glycol, Retinol, Allantoin, Helianthus Annuus Seed Oil Sunflower Seed Oil, Capryloyl Glycerin Sebacic Acid Copolymer, Ethylhexylglycerin, Willow Bark Extract, Camellia Sinensis Leaf Extract, Lilium Candidum Bulb Extract

Behind this fit score

Lovi calculates every fit score from the full ingredient list with brand-independent rules our dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update.