Retinoid blend and hexapeptide-9
Keep them apart
Use them at different times of day, applying your retinoid at night and hexapeptide-9 in the morning to prevent extra skin irritation. Both ingredients work hard to renew your skin, but using them together can cause redness and irritation. You can safely use both by switching to a gentler retinoid or giving your skin more time between applications.
All about retinoid blend
All about hexapeptide-9Retinoid blend products
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Sunday Riley
A+ High-Dose Retinoid Serum
拢127.42
Hexapeptide-9 products
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Elemis
Pro-Collagen Night Cream
拢96.00
- Murad Cellular Hydration Repair Serum
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MARY & MAY
6 Peptide Complex Serum
拢12.76
Questions and answers
Can you use retinoid blend and hexapeptide-9 together?
No, you should keep retinoid blend and hexapeptide-9 apart in your routine because combining them may increase irritation since both activate dermal remodeling pathways. Instead, alternate their usage by applying the retinoid in the PM and peptides in the AM.
Which goes first, retinoid blend or hexapeptide-9?
Keep them apart by alternating usage, such as applying your retinoid blend in the PM and hexapeptide-9 in the AM, because combining them may increase irritation.
Are retinoid blend and hexapeptide-9 good for sensitive skin?
Keep retinoid blend and hexapeptide-9 apart in your routine because combining them may increase irritation. Alternate their usage by applying your retinoid in the evening and hexapeptide-9 in the morning, which helps mature and sensitive skin.
Research on retinoid blend and hexapeptide-9
Behind this pairing advice
Lovi checks every pairing with brand-independent rules our dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update.
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Co-founder, Medical Director
Cosmetic chemist, cosmetologist, aesthetic products developer
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Co-founder, CEO and CTO
PhD in computer science, 3x US patent holder, ex-Google, ex-Yandex
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Dr. Sof铆a Perea P茅rez, MD, MSc
Medical Board
Aesthetic medicine practitioner, MSc in Longevity and Anti-Aging Medicine
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Medical Board
Specialist dermatologist, MBBS, MD, IFAAD
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Medical Board
Cosmetic chemist, SCS, IFSCC member
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Medical Board, Medical Advisor
Dermatology MD
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Elina Nazarenko, MD
Medical Board
Dermatology and diagnostic consultant
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Victoria Derkova, MS
Medical Board
Cosmetic chemist, cosmetic development technologist
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