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Retinoid blend and hexapeptide-9

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Retinoid blend and hexapeptide-9: keep them apart

Keep them apart

Use them at different times of day, applying your retinoid at night and hexapeptide-9 in the morning to prevent extra skin irritation. Both ingredients work hard to renew your skin, but using them together can cause redness and irritation. You can safely use both by switching to a gentler retinoid or giving your skin more time between applications.

Retinoid blend products

Hexapeptide-9 products

Questions and answers

Can you use retinoid blend and hexapeptide-9 together?

No, you should keep retinoid blend and hexapeptide-9 apart in your routine because combining them may increase irritation since both activate dermal remodeling pathways. Instead, alternate their usage by applying the retinoid in the PM and peptides in the AM.

Which goes first, retinoid blend or hexapeptide-9?

Keep them apart by alternating usage, such as applying your retinoid blend in the PM and hexapeptide-9 in the AM, because combining them may increase irritation.

Are retinoid blend and hexapeptide-9 good for sensitive skin?

Keep retinoid blend and hexapeptide-9 apart in your routine because combining them may increase irritation. Alternate their usage by applying your retinoid in the evening and hexapeptide-9 in the morning, which helps mature and sensitive skin.

Research on retinoid blend and hexapeptide-9

Behind this pairing advice

Lovi checks every pairing with brand-independent rules our dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update.

  • Nadia Kapleva, MS

    Nadia Kapleva, MS

    Co-founder, Medical Director

    Cosmetic chemist, cosmetologist, aesthetic products developer

  • Alexey Shagraev, PhD

    Alexey Shagraev, PhD

    Co-founder, CEO and CTO

    PhD in computer science, 3x US patent holder, ex-Google, ex-Yandex

  • Dr. Sof铆a Perea P茅rez, MD, MSc

    Dr. Sof铆a Perea P茅rez, MD, MSc

    Medical Board

    Aesthetic medicine practitioner, MSc in Longevity and Anti-Aging Medicine

  • Aishani Shah, MD

    Aishani Shah, MD

    Medical Board

    Specialist dermatologist, MBBS, MD, IFAAD

  • Asya Zubkova, MS

    Asya Zubkova, MS

    Medical Board

    Cosmetic chemist, SCS, IFSCC member

  • Hanna Kurets, MD

    Hanna Kurets, MD

    Medical Board, Medical Advisor

    Dermatology MD

  • Elina Nazarenko, MD

    Elina Nazarenko, MD

    Medical Board

    Dermatology and diagnostic consultant

  • Victoria Derkova, MS

    Victoria Derkova, MS

    Medical Board

    Cosmetic chemist, cosmetic development technologist

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