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Glycerin and hexapeptide-9

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Glycerin and hexapeptide-9: work well together

Work well together

Use them together by applying the glycerin serum before the hexapeptide cream, because hydration helps the peptide sink in better. Glycerin quenches the skin with moisture while hexapeptide-9 helps firm the look of the face, making them a great team for a smooth glow. You can use them both at standard strength, or just wait a minute between layers if you want to give the first product time to settle.

Effects of water activity and low molecular weight humectants on skin permeability and hydration dynamics - a double-blind, randomized and controlled studyThe efficiency of humectants as skin moisturizers in the presence of oil

Glycerin products

Hexapeptide-9 products

Questions and answers

Can you use glycerin and hexapeptide-9 together?

Yes, you can use glycerin and hexapeptide-9 together because they work well to boost hydration and support your skin barrier. Layer a hydrating serum containing glycerin beneath your peptide product for best results.

Clinical, Cosmetic and Investigational Dermatology, 2017Journal of Cosmetic Dermatology, 2025

Which goes first, glycerin or hexapeptide-9?

Glycerin goes first because you should layer your hydrating serum containing glycerin beneath your peptide product. This combination enhances hydration and supports peptide delivery.

Are glycerin and hexapeptide-9 good for sensitive skin?

Yes, glycerin and hexapeptide-9 work well together to enhance hydration and support barrier integrity for all skin types. Combining them helps increase peptide diffusion and improves skin moisture.

Clinical, Cosmetic and Investigational Dermatology, 2017

Research on glycerin and hexapeptide-9

Behind this pairing advice

Lovi checks every pairing with brand-independent rules our dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update.

  • Nadia Kapleva, MS

    Nadia Kapleva, MS

    Co-founder, Medical Director

    Cosmetic chemist, cosmetologist, aesthetic products developer

  • Alexey Shagraev, PhD

    Alexey Shagraev, PhD

    Co-founder, CEO and CTO

    PhD in computer science, 3x US patent holder, ex-Google, ex-Yandex

  • Dr. Sof铆a Perea P茅rez, MD, MSc

    Dr. Sof铆a Perea P茅rez, MD, MSc

    Medical Board

    Aesthetic medicine practitioner, MSc in Longevity and Anti-Aging Medicine

  • Aishani Shah, MD

    Aishani Shah, MD

    Medical Board

    Specialist dermatologist, MBBS, MD, IFAAD

  • Asya Zubkova, MS

    Asya Zubkova, MS

    Medical Board

    Cosmetic chemist, SCS, IFSCC member

  • Hanna Kurets, MD

    Hanna Kurets, MD

    Medical Board, Medical Advisor

    Dermatology MD

  • Elina Nazarenko, MD

    Elina Nazarenko, MD

    Medical Board

    Dermatology and diagnostic consultant

  • Victoria Derkova, MS

    Victoria Derkova, MS

    Medical Board

    Cosmetic chemist, cosmetic development technologist

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