Good Molecules Niacinamide Serum for mature skin
Niacinamide
Glycerin
Dipropylene Glycol
Betaine
Hydroxyethyl Acrylate Sodium Acryloyldimethyl Taurate Copolymer
Average
- HighNormal Skin Fit
- AverageEffectiveness
- ExcellentSafety
Works for mature skin; other serums fit it better.
This fit is calculated for the concerns frequently associated with mature skin: fine lines, wrinkles, and loss of firmness. For scores and recommendations based on your full skin profile, including your 12D face scan results and any goals or preferences you have, please use the Lovi app.
Page built Nov 8, 2026How the Fit score works
Lovi Assistant explains
- Suitable for normal skin, this serum utilizes niacinamide and glycerin to provide antioxidant and humectant benefits, which support hydration and offer mild improvements for wrinkles and fine lines.
- The formula also includes betaine and dipropylene glycol to further enhance skin hydration and texture, contributing to overall skin health.
- The safety profile is excellent, with no risks of irritation due to the absence of harsh ingredients and the inclusion of soothing components.
How to apply
- Use this serum in your PM routine. Start by applying it 3 times a week, and work up to daily use if your skin likes it.
- Apply this serum after your toner and before your moisturizer.
- Gently press 2-3 drops of the serum into your skin and let it absorb for a minute.
- You can apply the serum on dry skin for the best results against fine lines.
- Always do a patch test before your first use and avoid the sensitive eye area.
People Say
★4.6Overall rating based on 3.4k+ reviewsBased on a very large amount of data, this serum is highly regarded for its lightweight, non-sticky feel and its effectiveness in visibly reducing pores and smoothing skin texture, all at an accessible price. Many users found it beneficial for controlling oil and redness. A smaller number of users reported experiencing breakouts or irritation, indicating it might not be suitable for all sensitive skin types.
Highlights
Affordable price Mostly Mentioned
- “great value”
- “inexpensive”
- “worth every penny”
Improves texture Often Mentioned
- “smoother skin”
- “improved skin texture”
- “refine skin tone”
Minimizes pores Often Mentioned
- “pores are much smaller”
- “reduction in pore size”
- “less visible pores”
Controls oil/redness Sometimes Noted
- “calm my skin”
- “helping with oil production”
- “improvement in redness”
Elegant texture Sometimes Noted
- “absorbs right away”
- “not sticky or greasy”
- “layers seamlessly”
Caused breakouts Sometimes Noted
- “gave me little white bumps”
- “breaking out a ton”
- “caused acne”
No visible results Rarely Noted
- “don't see much difference”
- “no obvious improvement”
- “did nothing”
Packaging issues Rarely Noted
- “dropper is difficult”
- “hard to dispense”
- “bottle design flaws”
Skin irritation Rarely Noted
- “skin started tingling”
- “irritation on my face”
- “burning sensation”
Sources: lovi.care, beautylish.com, target.com, walmart.com, skinsort.com, and more
Questions and answers
How well does the Good Molecules Niacinamide Serum work for mature skin?
This serum works for mature skin by using niacinamide and glycerin to support hydration and help smooth out fine lines, though other products fit this skin type better. It is important for a product of this type to be exceptionally safe with no risk of irritation, effectively target wrinkles and fine lines with high-quality ingredients, perform its intended anti-aging function excellently, and be perfectly suitable for normal skin.
Which ingredients make this serum a good fit for mature skin?
Niacinamide and glycerin make this serum a good fit for mature skin by supporting hydration and offering mild improvements for wrinkles and fine lines, while betaine and dipropylene glycol enhance overall texture. To provide a better fit for mature skin, a product of this type needs high concentrations of potent antioxidants, skin-repairing ingredients, and peptides that effectively target wrinkles, improve elasticity, and ensure optimal moisture retention.
Clinical, Cosmetic and Investigational Dermatology, 2017Molecules, 2024
What does Niacinamide do for mature skin?
Niacinamide helps mature skin by smoothing out fine lines and wrinkles, reducing dark spots, and improving overall skin elasticity. It is also very well tolerated and supports a strong skin barrier to keep skin looking healthy.
What does Glycerin do for mature skin?
Glycerin helps keep mature skin feeling soft and smooth by drawing moisture into the outer layer and locking it in. This daily hydration boost supports the skin barrier, keeping dry areas comfortable and protected against irritation.
The British Journal of Dermatology, 2008Clinical, Cosmetic and Investigational Dermatology, 2017
Where does this serum go in a skincare routine for mature skin?
This serum goes in the evening routine after your cleanser and toner, and before your moisturizer. Putting treatments in the evening keeps things simple and provides extra safety around sun exposure.
Can I use this serum with retinol, and in what order?
Yes, you can use this serum with retinol by applying the serum first to keep your skin calm and hydrated before layering retinol on top. This product is unlikely to cause irritation because it lacks harsh ingredients and includes soothing components. To better support mature skin, a product of this type needs richer anti-aging ingredients and deep moisturizers.
How often should I use this serum?
You can use this treatment in the evening as part of your routine. It is very gentle and unlikely to cause irritation, so mature skin benefits when it is paired with richer moisturizers, antioxidants, and retinols to better smooth fine lines and boost hydration.
Facial Plastic Surgery, 2014Clinical, Cosmetic and Investigational Dermatology, 2017
Can this serum clog pores, cause breakouts or purging for mature skin?
This serum may occasionally cause breakouts, as some reviewers have reported. To better suit mature skin and minimize breakout risks, a product of this type needs soothing ingredients and hydration boosters like niacinamide and glycerin.
Is this serum fragrance-free and alcohol-free?
Yes, it has no fragrance and no drying alcohol.
What the research says
A single application of a moisturizing fluid containing hyaluronic acid 1%, glycerin 5%, and Centella asiatica stem cells extract significantly increased skin hydration by 29% and reduced transepidermal water loss at 24 hours compared to baseline and an untreated control site in twenty healthy women.
Clinical, Cosmetic and Investigational Dermatology, 2017Topical post-laser application of human adipocyte-derived mesenchymal stem cell media combined with niacinamide significantly improved wrinkle index, melanin index, patient satisfaction, and investigator esthetic improvement scores compared to vehicle cream in patients with aging skin.
Journal of Cosmetic Dermatology, 2021A combination of Aloe barbadensis leaf extract and trimethylglycine in a 1:1 mass ratio synergistically increased aquaporin 3 expression by up to 380% in keratinocytes and safely improved skin hydration in healthy volunteers.
Molecules, 2024Soaps containing betaine caused the least skin irritation compared to other tested soaps in twenty-eight healthy subjects, though irritation did not decrease with increasing concentrations of betaine.
Skin Research and Technology, 2003Topical nicotinamide prevented solar-simulated UV-induced immunosuppression in healthy volunteers, and men experienced immunosuppression at solar-simulated UV doses three times lower than those required for women.
The Journal of Investigative Dermatology, 2008Topical 5% niacinamide applied twice daily for 12 weeks reduced fine lines and wrinkles, hyperpigmented spots, red blotchiness, and skin sallowness, and improved skin elasticity compared to vehicle control in 50 female white subjects with facial photoaging.
Dermatologic Surgery, 2005Topical 2% niacinamide significantly decreased sebum excretion rate in Japanese individuals and casual sebum levels in Caucasian individuals compared to placebo or baseline.
Journal of Cosmetic and Laser Therapy, 2006The emollient V0034CR significantly reduced TEWL compared to vehicle and vehicle plus glycerol, and significantly increased corneometry scores compared to vehicle and vehicle plus petrolatum in healthy volunteers with dry skin, demonstrating combined barrier function improvement from petrolatum and hydration improvement from glycerol.
Journal of Cosmetic Dermatology, 2020Ten days of treatment with a cream containing 20% glycerin significantly increased skin hydration measured by corneometer values in 17 healthy volunteers compared to a placebo cream, but showed no influence on transepidermal water loss or skin sensitivity to an irritating surfactant.
International Journal of Cosmetic Science, 2001Niacinamide/glycerin body moisturizers provided better rapid and prolonged improvement of cosmetic xerosis through functional improvement of stratum corneum barrier function compared to no treatment and conventional moisturizers in female subjects.
Journal of Drugs in Dermatology, 2012Topical dry mouth products containing olive oil, betaine, and xylitol significantly increased unstimulated whole salivary flow rates, reduced xerostomia complaints, and improved quality of life in adults with polypharmacy-induced xerostomia compared to their normal routine care, with no clinically significant adverse events.
Journal of Oral Rehabilitation, 2007Mixed surfactant systems of sodium dodecyl sulfate and dimethyl dodecyl amido betaine significantly reduce acute skin irritation potential in human volunteers compared with the individual surfactants, demonstrating that irritation potential cannot be predicted by simple summation.
Food and Chemical Toxicology, 1998Polyhexanide/betaine may be nontoxic and effective in enhancing wound healing, whereas the majority of other topical cleaning agents are locally toxic and of limited or no proven efficacy.
Advances in Skin & Wound Care, 2013
Ingredients
Water, Niacinamide, Dipropylene Glycol, Glycerin, 1,2-Hexanediol, Betaine, Hydroxyethyl Acrylate Sodium Acryloyldimethyl Taurate Copolymer, Xanthan Gum, Ethylhexylglycerin, Polysorbate 60, Sorbitan Isostearate, Diphenyl Dimethicone, Disodium Edta, Triethylhexanoin, Polyglyceryl-10 Oleate, Hydrogenated Lecithin, Phenoxyethanol, Chlorphenesin, Caprylyl Glycol
Behind this fit score
Lovi calculates every fit score from the full ingredient list with brand-independent rules our dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update.
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Co-founder, Medical Director
Cosmetic chemist, cosmetologist, aesthetic products developer
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Co-founder, CEO and CTO
PhD in computer science, 3x US patent holder, ex-Google, ex-Yandex
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Dr. Sofía Perea Pérez, MD, MSc
Medical Board
Aesthetic medicine practitioner, MSc in Longevity and Anti-Aging Medicine
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Medical Board
Specialist dermatologist, MBBS, MD, IFAAD
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Medical Board
Cosmetic chemist, SCS, IFSCC member
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Medical Board, Medical Advisor
Dermatology MD
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Elina Nazarenko, MD
Medical Board
Dermatology and diagnostic consultant
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Victoria Derkova, MS
Medical Board
Cosmetic chemist, cosmetic development technologist
How does it fit your skin?
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