Allies of Skin 1A Retinal & Peptides Overnight Mask for mature skin

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What the research says

• A multi-modal methodology combining MALDI-MSI, in vivo RCM, echography, and histology revealed age-related decreases in extracellular matrix and epidermal-dermal junction proteins and undulation depth, while a blend of palmitoyl oligopeptide and palmitoyl tetrapeptide-7 improved subepidermal low-echogenic band thickness, density, and extracellular matrix structure compared to placebo.

  Journal of Cosmetic Dermatology, 2015

• A single application of a moisturizing fluid containing hyaluronic acid 1%, glycerin 5%, and Centella asiatica stem cells extract significantly increased skin hydration by 29% and reduced transepidermal water loss at 24 hours compared to baseline and an untreated control site in twenty healthy women.

  Clinical, Cosmetic and Investigational Dermatology, 2017

• Topical post-laser application of human adipocyte-derived mesenchymal stem cell media combined with niacinamide significantly improved wrinkle index, melanin index, patient satisfaction, and investigator esthetic improvement scores compared to vehicle cream in patients with aging skin.

  Journal of Cosmetic Dermatology, 2021

• Treatment with a combination of niacinamide and hyaluronic acid improved skin aging signs and demonstrated a senomorphic effect by decreasing SASP and autocrine signaling genes in women.

  Scientific Reports, 2024

• Twice daily application of retinaldehyde 0.1% and 0.05% creams for 3 months improved skin texture and hydration and reduced transepidermal water loss in 40 female Korean volunteers, with only the 0.1% cream significantly improving the melanin index.

  Journal of Cosmetic Dermatology, 2018

• Topical retinaldehyde demonstrated significant antibacterial activity against gram-positive bacteria both in vitro and in vivo, leading to decreased bacterial counts without inducing resistance.

  Dermatology, 2002

• Topical 0.05% retinaldehyde applied over 1 year significantly increased epidermal thickness of the temple and cutaneous elasticity compared to an emollient control group in 40 aging skin patients.

  Dermatology, 1999

• Topical nicotinamide prevented solar-simulated UV-induced immunosuppression in healthy volunteers, and men experienced immunosuppression at solar-simulated UV doses three times lower than those required for women.

  The Journal of Investigative Dermatology, 2008

• Topical 5% niacinamide applied twice daily for 12 weeks reduced fine lines and wrinkles, hyperpigmented spots, red blotchiness, and skin sallowness, and improved skin elasticity compared to vehicle control in 50 female white subjects with facial photoaging.

  Dermatologic Surgery, 2005

• Topical 2% niacinamide significantly decreased sebum excretion rate in Japanese individuals and casual sebum levels in Caucasian individuals compared to placebo or baseline.

  Journal of Cosmetic and Laser Therapy, 2006

• Topical application of 0.1% hyaluronic acid formulations of different molecular weights led to significant improvements in skin hydration and elasticity, with low-molecular-weight formulations also significantly reducing wrinkle depth in seventy-six female subjects compared to a vehicle control.

  Journal of Drugs in Dermatology, 2011

• Topical application of hyaluronic acid in conjunction with free gingival graft significantly reduced donor site postoperative pain until day 7 compared to normal saline, with no significant differences in graft dimensions or patient satisfaction.

  Clinical Oral Investigations, 2022

• Treatment with a hyaluronic acid-containing mouth rinse or topical gel led to significant lesion reduction, pain relief, and normalization of lesion color in adult patients with minor recurrent aphthous stomatitis, with the gel formulation showing an earlier healing onset at 3 days.

  BMC Oral Health, 2019

• A 0.4% formulation of natural pterostilbene reduced markers of aging, wrinkles, and fine lines while improving skin hydration and elasticity in healthy volunteers over 8 weeks.

  Clinical, Cosmetic and Investigational Dermatology, 2020

• Pterostilbene at 20 μM protected HaCaT keratinocytes from particulate matter-induced damage by reducing intracellular ROS, inhibiting AHR nuclear translocation, suppressing inflammation and aging protein cascades, and rescuing moisturizing protein expression.

  Antioxidants, 2021

• Topical pterostilbene is equally or more potent than resveratrol in inhibiting TPA-induced AP-1, NF-kappaB, COX-2, and iNOS activation in mouse epidermis.

  Molecular Nutrition & Food Research, 2008

Ingredients

Water, Glycerin, Caprylic Capric Triglyceride, Propanediol, Argania Spinosa Kernel Oil Argan Kernel Oil, Sodium Acrylates Copolymer, Citrus Aurantium Dulcis Callus Culture Extract, Retinal, Sodium Stearoyl Glutamate, Hydrolyzed Candida Saitoana Extract, Albizia Julibrissin Bark Extract, Dimethyl Isosorbide, Galactoarabinan, Palmitoyl Tetrapeptide-7, Palmitoyl Oligopeptide, Caprooyl Tetrapeptide-3, Cassia Angustifolia Polysaccharide Seed Alexandrian Senna Seed Polysaccharide Seed, Sodium Hyaluronate, Oxycoccus Palustris Seed Oil Cranberry Seed Oil, Rubus Chamaemorus Berry Seed Oil Cloud Berry Seed Oil, Niacinamide, Pterostilbene, Ellagic Acid, Phenyl T-Butylnitrone Spin Trap, Ergothioneine, Glutathione, Mirabilis Jalapa Extract, N-Hydroxysuccinimide, Chrysin, Glutamyl Amidoethyl Imidazole, Lonicera Caprifolium Flower Extract Honeysuckle Flower Extract, Lonicera Japonica Flower Extract Honeysuckle Flower Extract, Lavandula Hybrida Oil, Pentylene Glycol, Butylene Glycol, Cyclodextrin, Caprylyl Glycol, Xanthan Gum, Dextran, Acetyl Tributyl Citrate, Citric Acid, Potassium Sorbate, Phenoxyethanol, Geraniol, Limonene, Linalool

Behind this fit score

Lovi calculates every fit score from the full ingredient list with brand-independent rules our dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update.