SkinCeuticals A.G.E. Eye Complex for skin with dark spots

Questions and answers

What the research says

• A multi-modal methodology combining MALDI-MSI, in vivo RCM, echography, and histology revealed age-related decreases in extracellular matrix and epidermal-dermal junction proteins and undulation depth, while a blend of palmitoyl oligopeptide and palmitoyl tetrapeptide-7 improved subepidermal low-echogenic band thickness, density, and extracellular matrix structure compared to placebo.

  Journal of Cosmetic Dermatology, 2015

• Palmitoyl tetrapeptide-7, acetyl hexapeptide-8, palmitoyl tripeptide-1, and palmitoyl tetrapeptide-10 significantly increased type III collagen levels in human dermal fibroblasts following UV exposure, with their combination demonstrating a greater effect in vitro and enhancing type I, III, and IV collagen levels in ex vivo skin tissues compared to individual components.

  International Journal of Cosmetic Science, 2026

• A single application of a moisturizing fluid containing hyaluronic acid 1%, glycerin 5%, and Centella asiatica stem cells extract significantly increased skin hydration by 29% and reduced transepidermal water loss at 24 hours compared to baseline and an untreated control site in twenty healthy women.

  Clinical, Cosmetic and Investigational Dermatology, 2017

• Topical application of 5% vitamin C cream significantly improved global clinical scores, increased skin microrelief density, and induced elastic tissue repair in photoaged skin compared to excipient control in healthy female volunteers.

  Experimental Dermatology, 2003

• Ascorbic acid 2-glucoside gel significantly reduced gingival melanin pigmentation after 4 weeks compared to placebo in 73 subjects with symmetric pigmentation.

  Journal of Periodontology, 2009

• Topical application of VC-IP cream twice daily for 8 weeks reduces periorbital wrinkles in female subjects compared to a placebo cream.

  Journal of Cosmetic Dermatology, 2022

• A topical cosmetic slimming product containing tetrahydroxypropyl ethylenediamine, caffeine, carnitine, forskolin and retinol significantly reduced body circumferences and improved skin aspect compared with placebo in 78 women over 12 weeks.

  International Journal of Cosmetic Science, 2011

• Topical sunscreen formulations containing caffeine combined with UV filters increased in vivo anti-UVB protection by approximately 25% and showed higher SPF values compared to caffeine-free sunscreen, while being well tolerated by the skin of healthy subjects.

  Frontiers in Physiology, 2019

• Caffeine gel combined with choline geranate showed high skin permeation capacity and superior clinical results in cellulite treatment compared to caffeine gel without ionic liquid.

  AAPS PharmSciTech, 2021

• Application of a hydroxypropyl tetrahydropyrantriol and niacinamide formula following nonablative fractional laser treatment demonstrated comparable healing benefits to clinical control and significant improvements in fine lines, crow's feet wrinkles, skin roughness, and overall healthy appearance over 56 days in White and Northeast Asian panels.

  The Journal of Clinical and Aesthetic Dermatology, 2025

• Topical formulation containing hesperidin methyl chalcone inhibited skin oxidative stress, inflammation, and cytokine production induced by ultraviolet B irradiation in hairless mice.

  Photochemical & Photobiological Sciences, 2016

Why other eye cares fit skin with dark spots better

• An antipollution, antioxidant serum containing Deschampsia antarctica extract, ferulic acid, and vitamin C reduced transepidermal water loss by 19%, improved dark spots by 7%, and decreased the squalene peroxide to squalene ratio by 16% compared to baseline in twenty women living in a high air pollution area over 28 days.

  Clinical, Cosmetic and Investigational Dermatology, 2019

• Topical bakuchiol 0.5% applied twice daily compared with retinol 0.5% applied daily significantly decreased wrinkle surface area and hyperpigmentation with no statistical difference between the compounds in 44 patients over 12 weeks, while retinol users reported more facial skin scaling and stinging.

  The British Journal of Dermatology, 2019

• Niacinamide significantly decreased hyperpigmentation and increased skin lightness compared with vehicle alone after 4 weeks of use in women by inhibiting melanosome transfer.

  The British Journal of Dermatology, 2002

Ingredients

Water, Glycerin, Dimethicone, Isohexadecane, Paraffin, Silica, Polyglyceryl-4 Isostearate, Propylene Glycol, Cetyl Peg Ppg-10 1 Dimethicone, Hexyl Laurate, Nylon-12, Hydroxypropyl Tetrahydropyrantriol, Methylsilanol Silicate Crosspolymer, Polyethylene, Ascorbyl Glucoside, Caprylic Capric Triglyceride, Octyldodecanol, Tocopheryl Acetate, Vaccinium Myrtillus Extract, Vaccinium Myrtillus Fruit Extract, Sodium Citrate, Phenoxyethanol, Stearic Acid, Caffeine, Peg-6 Isostearate, Ethylparaben, N-Hydroxysuccinimide, Triethanolamine, Chlorphenesin, Palmitoyl Tetrapeptide-7, Palmitoyl Oligopeptide, Ammonium Polyacryldimethyltauramide, Ammonium Polyacryloyldimethyl Taurate, Menthoxypropanediol, Pentasodium Pentetate, Dipeptide-2, Chrysin, Hesperidin Methyl Chalcone, Hesperetin Laurate, Methylparaben, Titanium Dioxide, Aluminum Hydroxide

Behind this fit score

Lovi calculates every fit score from the full ingredient list with brand-independent rules our dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update.