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NIOD Modulating Glucosides for dry skin

Rated by Lovi · Unbiased, science-based skincare AI trained on real user outcomes

NIOD Modulating Glucosides

High

  • HighDry Skin Fit
  • HighEffectiveness
  • HighSafety

A great choice for dry skin; a few serums fit it even better.

This fit is calculated for the concerns frequently associated with dry skin: flakiness, tightness, dehydration, fine lines, and wrinkles. For scores and recommendations based on your full skin profile, including your 12D face scan results and any goals or preferences you have, please use the Lovi app.

Page built Nov 8, 2026How the Fit score works

Lovi Assistant explains

  • Highly suitable for your dry skin, this formula leverages Squalane and Glycerin to provide essential emollient and humectant actions, supporting barrier repair and hydration for your dry or flaky skin.
  • The inclusion of Bisabolol and Tasmannia Lanceolata Leaf Extract offers excellent soothing and anti-redness effects, further calming irritated skin.
  • The safety profile is excellent, with no risks of irritation due to the absence of harsh ingredients and the presence of soothing components.

How to apply

  • Apply this serum PM, starting 3×/week and working up to daily use as your skin adjusts.
  • Place the serum after cleansing and toner, but right before your moisturizer.
  • Gently press 2-3 drops of the serum into your skin and let it absorb for a minute.
  • Apply the serum on slightly damp skin to help lock in extra moisture.
  • Avoid the eye area and do a patch test before your first use.

People Say

★4.8Overall rating based on 400+ reviews

This serum is highly praised for its ability to calm sensitive, reactive, and irritated skin, with users frequently reporting significant improvements in redness, stinging, and compromised skin barriers. It is a popular choice for those recovering from aesthetic treatments or harsh active ingredients. Some users with normal skin may find the benefits less noticeable or the texture slightly heavy.

Highlights

  • Calms sensitive skin Mostly Mentioned
    • “Like medicine to irritated skin.”
    • “Great for sensitive, reactive skin.”
    • “Helps quiet sensations of stinging and itching.”
  • Reduces skin redness Often Mentioned
    • “Visibly reduced redness for a more even tone.”
    • “Calms redness and stinging.”
    • “It really did wonders in soothing skin and reducing redness.”
  • Buffers active irritation Sometimes Noted
    • “Helps minimise the side effects of retinoids.”
    • “Buffers retinoid/acid irritation.”
    • “Reason my skin had been so calm while I was on Roaccutane.”
  • Strengthens skin barrier Sometimes Noted
    • “Saved my skin barrier from beyond hope.”
    • “Strengthens skin barrier integrity over time.”
    • “Especially helpful when my barrier is compromised.”
  • Inconvenient packaging Sometimes Noted
    • “Dropper bottle is messy to use.”
    • “Not my favorite type of packaging.”
    • “Why doesn't it come with a pump?”
  • Subtle for normal skin Sometimes Noted
    • “If you have normal skin, benefits may not be apparent.”
    • “I did not notice any improvement.”
  • Can cause breakouts Rarely Noted
    • “It broke me out almost instantly.”
    • “Heavy going on my face.”
  • Unappealing scent Rarely Noted
    • “Strong nutty scent.”
    • “A bit like paint.”
    • “Has a bit of a medicinal smell.”

Sources: lovi.care, niod.com, skinsort.com, dermapproved.com, drrachelho.com, daniellesbeautyblog.com, and more

Questions and answers

What makes Modulating Glucosides a great fit for dry skin?

This product is a great fit for dry skin because it combines squalane and glycerin to help keep your skin soft and hydrated while supporting your skin barrier. It also includes soothing ingredients like bisabolol to help calm any irritation or redness, and is unlikely to cause any irritation.

The Journal of Clinical and Aesthetic Dermatology, 2012

Which ingredients make this serum a good fit for dry skin?

This serum is a great fit for dry skin because it uses squalane and glycerin to add deep moisture and help repair your skin barrier, while bisabolol helps calm irritation and redness. The formula is very safe for dry skin and is unlikely to cause irritation.

Skin Pharmacology and Physiology, 2012The Journal of Clinical and Aesthetic Dermatology, 2012

What do Glucosides do for dry skin?

Glucosides help very dry skin feel smooth and soft by boosting moisture levels and keeping hydration locked in. This ingredient supports your skin's natural water channels to reduce visible dryness and rough patches.

Skin Pharmacology and Physiology, 2012The Journal of Clinical and Aesthetic Dermatology, 2012

What does Squalane do for dry skin?

Squalane helps keep dry skin soft and smooth by acting as a hydrating agent that locks in moisture and prevents water loss. It is unlikely to cause irritation and may protect the skin from damage while improving overall hydration.

Advances in Food and Nutrition Research, 2012Molecules, 2009

Where does this serum go in a skincare routine for dry skin?

This treatment serum goes in the evening routine for dry skin, applied after cleansing and before moisturizing. This timing keeps the routine simple and adds safety around sun exposure, while helping hydrate and calm your dry skin.

Can I use this serum with retinol, and in what order?

You can use this treatment alongside retinol by applying it before your retinol at night to help keep your dry skin calm and hydrated. Its soothing ingredients and excellent safety profile mean it is unlikely to cause irritation when paired with active treatments.

How often should I use this serum?

You can use this treatment in the evening as part of your routine. It is a great fit for your dry skin because it helps hydrate, repair the skin barrier, and calm irritation without causing dryness.

The Journal of Clinical and Aesthetic Dermatology, 2012Skin Pharmacology and Physiology, 2012

Can this serum clog pores, cause breakouts or purging for dry skin?

This serum is unlikely to cause breakouts on dry skin because it has an excellent safety profile without harsh ingredients. It helps keep skin calm and hydrated with soothing and moisturizing components.

The Journal of Clinical and Aesthetic Dermatology, 2012Clinical, Cosmetic and Investigational Dermatology, 2017

Is this serum fragrance-free and alcohol-free?

It has no drying alcohol and contains fragrance (benzyl alcohol).

What the research says

Ingredients

Water, Squalane, Isodecyl Neopentanoate, Glycerin, Caprylic Capric Triglyceride, Pentylene Glycol, Propanediol, Hexyldecanol, Bisabolol, Butylene Glycol, Epigallocatechin Gallatyl Glucoside, Rosmarinyl Glucoside, Caffeyl Glucoside, Gallyl Glucoside, Tetrasodium Tetracarboxymethyl Naringeninchalcone, Hydroxymethoxyphenyl Decanone, 4-T-Butylcyclohexanol, Cetylhydroxyproline Palmitamide, Hydroxyphenyl Propamidobenzoic Acid, Palmitoyl Tripeptide-8, Superoxide Dismutase, Sodium Pca, Pca, Arginine, Glycine, Alanine, Serine, Valine, Isoleucine, Proline, Threonine, Histidine, Phenylalanine, Aspartic Acid, Sodium Lactate, Mirabilis Jalapa Callus Extract, Tasmannia Lanceolata Leaf Extract Fruit, Zingiber Officinale Root Extract, Curculigo Orchioides Root Extract, Isochrysis Galbana Extract, Brassica Campestris Sterols, Stearic Acid, Dextran, Isoceteth-20, Polyacrylate Crosspolymer-6, Xanthan Gum, Tocopherol, Propyl Gallate, Tromethamine, Dehydroacetic Acid, 1,2-Hexanediol, Benzyl Alcohol, Phenoxyethanol, Caprylyl Glycol

Behind this fit score

Lovi calculates every fit score from the full ingredient list with brand-independent rules our dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update.

  • Nadia Kapleva, MS

    Nadia Kapleva, MS

    Co-founder, Medical Director

    Cosmetic chemist, cosmetologist, aesthetic products developer

  • Alexey Shagraev, PhD

    Alexey Shagraev, PhD

    Co-founder, CEO and CTO

    PhD in computer science, 3x US patent holder, ex-Google, ex-Yandex

  • Dr. Sofía Perea Pérez, MD, MSc

    Dr. Sofía Perea Pérez, MD, MSc

    Medical Board

    Aesthetic medicine practitioner, MSc in Longevity and Anti-Aging Medicine

  • Aishani Shah, MD

    Aishani Shah, MD

    Medical Board

    Specialist dermatologist, MBBS, MD, IFAAD

  • Asya Zubkova, MS

    Asya Zubkova, MS

    Medical Board

    Cosmetic chemist, SCS, IFSCC member

  • Hanna Kurets, MD

    Hanna Kurets, MD

    Medical Board, Medical Advisor

    Dermatology MD

  • Elina Nazarenko, MD

    Elina Nazarenko, MD

    Medical Board

    Dermatology and diagnostic consultant

  • Victoria Derkova, MS

    Victoria Derkova, MS

    Medical Board

    Cosmetic chemist, cosmetic development technologist

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