Clinique Even Better Clinical Radical Dark Spot Corrector + Interrupter for combination skin

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Questions and answers

What the research says

• Treatment with ascorbyl glucoside-arginine complex lotion significantly decreased pigmentation scores and melanin index while increasing lightness in solar lentigos of Japanese females compared to placebo over 24 weeks.

  International Journal of Molecular Sciences, 2024

• Ascorbic acid 2-glucoside gel significantly reduced gingival melanin pigmentation after 4 weeks compared to placebo in 73 subjects with symmetric pigmentation.

  Journal of Periodontology, 2009

• Twice daily application of a multitargeted dermocosmetic cream provided comparable efficacy to benzoyl peroxide 5% gel in reducing inflammatory, non-inflammatory, and total lesions in 150 Caucasian subjects with mild-to-moderate acne over 56 days, while demonstrating superior skin tolerability.

  Journal of Cosmetic Dermatology, 2024

• A dermo-cosmetic formula containing 2% enoxolone significantly reduced erythema at 24 hours and pain at 30 minutes following non-ablative fractional laser treatment in 10 healthy subjects compared to a moisturizer control.

  Journal of Cosmetic Dermatology, 2024

• Topical application of 5% vitamin C cream significantly improved global clinical scores, increased skin microrelief density, and induced elastic tissue repair in photoaged skin compared to excipient control in healthy female volunteers.

  Experimental Dermatology, 2003

• Topical application of VC-IP cream twice daily for 8 weeks reduces periorbital wrinkles in female subjects compared to a placebo cream.

  Journal of Cosmetic Dermatology, 2022

• Topical treatment with 5% vitamin C and 0.1% madecassoside significantly improved clinical scores for wrinkles, suppleness, firmness, roughness, and skin hydration, along with functional and structural remodeling of the elastic fiber network in 20 female volunteers with photoaged skin after 6 months compared to baseline.

  Experimental Dermatology, 2008

• Topical 2% N-acetyl glucosamine reduced facial hyperpigmentation in an 8-week split-face clinical test, with an even greater effect observed when combined with 4% niacinamide.

  Journal of Cosmetic Dermatology, 2007

• N-acetyl-glucosamine-loaded nanostructured lipid carriers successfully delivered the hydrophilic agent through the skin and reduced melanin distribution in healthy volunteers.

  Advanced Pharmaceutical Bulletin, 2016

• Topical cosmetic products containing hyaluronic acid, N-acetyl glucosamine, and gamma-amino butyric acid improved skin hydration by 24.28% to 33.60%, elasticity by 11.98%, and skin lightening by 5.26% over 2 months in 20 female participants.

  Journal of Cosmetic and Laser Therapy, 2019

• Cryotherapy with liquid nitrogen achieved a higher cure rate (39%) than salicylic acid (24%) and a wait-and-see approach (16%) for cutaneous warts at 13 weeks in primary care patients.

  CMAJ, 2010

• A moisturizer containing licochalcone A, 1,2-decanediol, L-carnitine, and salicylic acid significantly reduced noninflammatory, inflammatory, and total acne lesion counts compared to a vehicle control in Thai patients during a 12-week maintenance phase.

  BioMed Research International, 2020

• Treatment with 2% supramolecular salicylic acid hydrogel resulted in a regression and markedly improvement rate of 51.01% compared to 43.10% for Adapaline gel in patients with mild to moderate facial acne vulgaris, showing no significant difference in efficacy.

  Journal of Cosmetic Dermatology, 2024

• Topical application of a 2% cream containing combined fruit extracts for 56 days significantly reduced wrinkle depth by 11.5%, length by 10.07%, and area by 29.55% in 21 female subjects compared to a placebo.

  Clinical, Cosmetic and Investigational Dermatology, 2015

• Plant Milking technology applied to Morus alba L. produced an extract enriched in prenylated compounds with an 18-fold increase compared to commercial root extract and confirmed wrinkle reduction benefits in aged women.

  Molecules, 2020

• Morus alba root extract enhanced proliferation and up-regulated keratin expression and CXCL12/CXCR4 signaling in primary cell and skin explant cultures.

  Phytotherapy Research, 2015

Ingredients

Water, Cyclopentasiloxane, Dimethicone, Polysilicone-11, Isododecane, Butylene Glycol, Ascorbyl Glucoside, Peg-10 Dimethicone, Peg-6, Morus Bombycis Root Extract Morus Alba Root Extract, Scutellaria Baicalensis Root Extract, Camellia Sinensis Leaf Extract, Cucumis Sativus Fruit Extract, Saccharomyces Lysate Extract, Hordeum Vulgare Extract Extrait Dorge Extract, Salicylic Acid, Wheat Extract Germ Extract, Cholesterol, Rice Bran Extract, Squalane, Acetyl Glucosamine, Sodium Hyaluronate, Caffeine, Isohexadecane, Betula Alba Bark Extract, Trametes Versicolor Extract, Sodium Rna, Glycyrrhetinic Acid, Dimethoxytolyl Propylresorcinol, Di-C12-18 Alkyl Dimonium Chloride, Helianthus Annuus Seedcake Sunflower Seedcake, Caprylyl Glycol, Propylene Glycol Dicaprate, Ammonium Acryloyldimethyltaurate Vp Copolymer, Acrylamide Sodium Acryloyldimethyltaurate Copolymer, Polysorbate 20, Tocopheryl Acetate, Polysorbate 80, Tromethamine, Sodium Hydroxide, Hexylene Glycol, Disodium Edta, Sodium Benzoate, Sodium Metabisulfite, Sodium Sulfite, Phenoxyethanol, Ci 15985, Yellow 5 Ci 19140

Behind this fit score

Lovi calculates every fit score from the full ingredient list with brand-independent rules our dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update.