COSRX The 6 Peptide Skin Booster Serum for mature skin
Sodium Hyaluronate
Peptides
N-Acetyl Glucosamine
Niacinamide
AllantoinSuperior
- HighNormal Skin Fit
- SuperiorEffectiveness
- ExcellentSafety
One of the best moisturizers for mature skin.
This fit is calculated for the concerns frequently associated with mature skin: fine lines, wrinkles, and loss of firmness. For scores and recommendations based on your full skin profile, including your 12D face scan results and any goals or preferences you have, please use the Lovi app.
Page built Nov 8, 2026How the Fit score works
Lovi Assistant explains
- This serum is an excellent match for your normal skin, as the combination of acetyl hexapeptide-8 and copper tripeptide-1 effectively targets wrinkles and fine lines by promoting collagen synthesis and improving skin elasticity. Niacinamide and adenosine further support your skin barrier and provide antioxidant benefits, enhancing overall skin health.
- The inclusion of multiple peptides, such as sh-polypeptide-121 and dipeptide diaminobutyroyl benzylamide diacetate, ensures comprehensive anti-aging effects, plumping the skin and minimizing the appearance of fine lines.
- The product has a very safe profile for your skin, with soothing ingredients like tocopherol and glycerin and no harsh or prohibited substances.
How to apply
- Use your moisturizer twice a day in your AM and PM routines. Apply it daily to help smooth fine lines.
- Apply this product after your toner and serum, but before your SPF in the morning. Follow your cleanser and toner steps to keep your skin balanced.
- Gently press a small amount into your face and neck. Avoid rubbing the skin too harshly to prevent extra tension.
- Apply the moisturizer on slightly damp skin to help lock in extra moisture. Clean skin helps the product absorb much more evenly.
- Avoid the sensitive eye area during application. Do a quick patch test before your very first use to stay safe.
People Say
★4.7Overall rating based on 5.4k+ reviewsBased on a very large amount of data, users consistently praise this serum as a lightweight, water-like "booster" that significantly improves skin texture and hydration without heaviness. It is widely celebrated for smoothing pores and creating a "glass skin" glow. A small minority of users with specific sensitivities experienced breakouts or closed comedones.
Highlights
Lightweight & fast-absorbing Mostly Mentioned
- “absorbs instantly like water”
- “non-sticky finish”
- “perfect for layering”
- “feels weightless on oily skin”
Hydrating & plumping Often Mentioned
- “gives a healthy glow”
- “skin feels plump”
- “boosts hydration levels”
- “glass skin effect”
Improves skin texture Often Mentioned
- “skin feels softer immediately”
- “smoothed out my texture”
- “pores look smaller”
- “reduced roughness”
Gentle & non-irritating Sometimes Noted
- “no stinging on sensitive skin”
- “soothing application”
- “great for barrier repair”
- “gentle enough for daily use”
Caused breakouts Rarely Noted
- “gave me closed comedones”
- “caused tiny whiteheads”
- “broke me out after a week”
- “bad reaction for acne-prone skin”
Ingredient sensitivities Rarely Noted
- “reacted to the niacinamide”
- “contains soy oil (allergy warning)”
- “caused redness/flushing”
No visible results Rarely Noted
- “did absolutely nothing”
- “just expensive water”
- “no change in fine lines”
- “saw no difference after a bottle”
Sticky residue Rarely Noted
- “felt slightly tacky”
- “left a sticky film”
- “clashed with other products”
- “too slimy”
Sources: lovi.care, ulta.com, sokoglam.com, yesstyle.com, oliveyoung.com, amazon.com, and more
Questions and answers
What makes COSRX The 6 Peptide Skin Booster Serum one of the best fits for mature skin?
This serum is one of the best fits for mature skin because a blend of acetyl hexapeptide-8 and copper tripeptide-1 helps target fine lines while boosting firmness and smoothness. It also features niacinamide and adenosine to support your skin barrier and improve overall health with a very safe profile.
American Journal of Clinical Dermatology, 2013Journal of Cosmetic and Laser Therapy, 2013
Which ingredients make this serum a good fit for mature skin?
This serum is a great fit for mature skin because acetyl hexapeptide-8 and copper tripeptide-1 help smooth out wrinkles and fine lines. Niacinamide and adenosine further support your skin barrier and boost overall skin health, while soothing ingredients like glycerin keep things calm and safe.
American Journal of Clinical Dermatology, 2013Journal of Cosmetic and Laser Therapy, 2013
What does Hyaluronic Acid do for mature skin?
Hyaluronic acid helps mature skin by deeply boosting moisture, improving elasticity, and smoothing the appearance of fine lines and wrinkles. Regular use keeps the skin looking plump and soft while supporting overall firmness and hydration.
Journal of Drugs in Dermatology, 2011Skin Research and Technology, 2024
What do Peptides do for mature skin?
Peptides help mature skin by signaling skin cells to boost collagen production, which improves firmness and smooths out fine lines. They are generally safe to use daily, though their ability to deliver results depends heavily on how well the formula can sink into the skin.
International Journal of Cosmetic Science, 2009Biomolecules, 2025
Where does this serum go in a skincare routine for mature skin?
This serum goes in the evening routine after cleansing and before moisturizing, as putting treatments at night keeps things simple and safe around sun exposure. Using peptide and niacinamide treatments consistently helps target wrinkles, supports your skin barrier, and improves skin elasticity.
Journal of Drugs in Dermatology, 2023Journal of Drugs in Dermatology, 2025
Can I use this serum with retinol, and in what order?
You can use this serum with retinol by applying the serum first to help plump the skin and smooth out fine lines, followed by your retinol product. This approach allows the peptides and hydrating ingredients to condition mature skin while helping it tolerate the retinol better.
American Journal of Clinical Dermatology, 2013Journal of Cosmetic and Laser Therapy, 2013
How often should I use this serum?
You can use this serum in your evening routine, and some people also use it in the morning or twice a day. Applying it daily helps improve skin moisture, elasticity, and fine lines over time.
Journal of Cosmetic Dermatology, 2020Health Science Reports, 2021
Can this serum clog pores, cause breakouts or purging for mature skin?
This serum is unlikely to clog pores or cause breakouts, as it features a very safe profile with soothing ingredients and reviewers rarely report breakouts. It helps keep mature skin smooth without heavy oils that typically block pores.
Can I use this serum around the eyes or on my body?
You can use this serum around the eyes and on your body to help smooth out fine lines and keep the skin soft. It is very safe for delicate areas and unlikely to cause irritation.
Polymers, 2023American Journal of Clinical Dermatology, 2013
Is this serum fragrance-free and alcohol-free?
Yes, it has no fragrance and no drying alcohol.
What the research says
Argireline treatment twice daily for 4 weeks produced a significant anti-wrinkle effect with 48.9% total efficacy and decreased skin roughness in Chinese subjects compared with 0% efficacy and no decrease in roughness in the placebo group.
American Journal of Clinical Dermatology, 2013Argireline applied twice daily for 4 weeks achieved a total anti-wrinkle efficiency of 48.9% and notably reduced wrinkle depth compared to placebo in Chinese subjects.
Journal of Cosmetic and Laser Therapy, 2013Adenosine-loaded dissolving microneedle patches showed similar or better efficacy on skin wrinkles, dermal density, elasticity, and hydration compared to adenosine cream in 22 female subjects.
International Journal of Cosmetic Science, 2018A novel anti-aging serum containing acetyl hexapeptide-8, dipeptide diaminobutyroyl benzylamide diacetate, gluconolactone, niacinamide, and laminaria extract significantly increased anti-aging biomarkers and improved static and dynamic wrinkles as well as skin quality in clinical studies.
International Journal of Cosmetic Science, 2026Topical application of 0.1% hyaluronic acid formulations of different molecular weights led to significant improvements in skin hydration and elasticity, with low-molecular-weight formulations also significantly reducing wrinkle depth in seventy-six female subjects compared to a vehicle control.
Journal of Drugs in Dermatology, 2011Topical application of hyaluronic acid in conjunction with free gingival graft significantly reduced donor site postoperative pain until day 7 compared to normal saline, with no significant differences in graft dimensions or patient satisfaction.
Clinical Oral Investigations, 2022Treatment with a hyaluronic acid-containing mouth rinse or topical gel led to significant lesion reduction, pain relief, and normalization of lesion color in adult patients with minor recurrent aphthous stomatitis, with the gel formulation showing an earlier healing onset at 3 days.
BMC Oral Health, 2019Topical 2% N-acetyl glucosamine reduced facial hyperpigmentation in an 8-week split-face clinical test, with an even greater effect observed when combined with 4% niacinamide.
Journal of Cosmetic Dermatology, 2007N-acetyl-glucosamine-loaded nanostructured lipid carriers successfully delivered the hydrophilic agent through the skin and reduced melanin distribution in healthy volunteers.
Advanced Pharmaceutical Bulletin, 2016Topical cosmetic products containing hyaluronic acid, N-acetyl glucosamine, and gamma-amino butyric acid improved skin hydration by 24.28% to 33.60%, elasticity by 11.98%, and skin lightening by 5.26% over 2 months in 20 female participants.
Journal of Cosmetic and Laser Therapy, 2019Topical post-laser application of human adipocyte-derived mesenchymal stem cell media combined with niacinamide significantly improved wrinkle index, melanin index, patient satisfaction, and investigator esthetic improvement scores compared to vehicle cream in patients with aging skin.
Journal of Cosmetic Dermatology, 2021Topical nicotinamide prevented solar-simulated UV-induced immunosuppression in healthy volunteers, and men experienced immunosuppression at solar-simulated UV doses three times lower than those required for women.
The Journal of Investigative Dermatology, 2008Topical 5% niacinamide applied twice daily for 12 weeks reduced fine lines and wrinkles, hyperpigmented spots, red blotchiness, and skin sallowness, and improved skin elasticity compared to vehicle control in 50 female white subjects with facial photoaging.
Dermatologic Surgery, 2005Topical gel containing chitosan, 0.2% chlorhexidine, allantoin and dexpanthenol did not improve postoperative comfort regarding swelling and pain, but improved the wound's aesthetic appearance following impacted lower third molar extraction compared to no gel.
Medicina Oral, Patologia Oral Y Cirugia Bucal, 2016A topical gel containing chitosan, chlorhexidine, allantoin, and dexpanthenol significantly reduced postoperative pain, trismus, swelling, and analgesic consumption, while improving wound healing after third molar surgery compared to a placebo.
Medicina Oral, Patologia Oral Y Cirugia Bucal, 2020An overnight patch containing Allium cepa extract and allantoin safely promotes scar healing after dermatologic surgery, resulting in significantly greater reductions in observer- and patient-assessed POSAS scores compared to no treatment.
Aesthetic Plastic Surgery, 2018
Ingredients
Water, Dipropylene Glycol, Glycerin, Pentylene Glycol, 1,2-Hexanediol, Niacinamide, Ammonium Acryloyldimethyltaurate Vp Copolymer, Polyacrylate Crosspolymer-6, Butylene Glycol, Xanthan Gum, Ethylhexylglycerin, Adenosine, Polyquaternium-51, Disodium Edta, Citric Acid, Caprylyl Glycol, Betaine, T-Butyl Alcohol, Sodium Pca, Sodium Lactate, Acetyl Hexapeptide-8, Copper Tripeptide-1, Pca, Sh-Polypeptide-121, Serine, Alanine, Allantoin, Sodium Hyaluronate, Acetyl Glucosamine, Glycine, Glutamic Acid, Lysine Hcl, Threonine, Dipeptide Diaminobutyroyl Benzylamide Diacetate, Arginine, Tocopherol, Oligopeptide-68, Proline, Dextran, Palmitoyl Tripeptide-8, Glycine Soja Oil Soybean Oil, Hydrogenated Lecithin, Potassium Sorbate, Sodium Oleate
Behind this fit score
Lovi calculates every fit score from the full ingredient list with brand-independent rules our dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update.
-
Co-founder, Medical Director
Cosmetic chemist, cosmetologist, aesthetic products developer
-
Co-founder, CEO and CTO
PhD in computer science, 3x US patent holder, ex-Google, ex-Yandex
-
Dr. Sofía Perea Pérez, MD, MSc
Medical Board
Aesthetic medicine practitioner, MSc in Longevity and Anti-Aging Medicine
-
Medical Board
Specialist dermatologist, MBBS, MD, IFAAD
-
Medical Board
Cosmetic chemist, SCS, IFSCC member
-
Medical Board, Medical Advisor
Dermatology MD
-
Elina Nazarenko, MD
Medical Board
Dermatology and diagnostic consultant
-
Victoria Derkova, MS
Medical Board
Cosmetic chemist, cosmetic development technologist
How does it fit your skin?
Scan your face, then any product: Lovi shows how well it fits you and what fits even better.