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Gluconolactone

Rated by Lovi · Unbiased, science-based skincare AI trained on real user outcomes · How the Fit score works

Gluconolactone

Gluconolactone gently clears inflamed and non-inflamed acne lesions, balances sebum and moisture, and refines skin tone and pores with remarkably few side-effects. This versatile ingredient suits dry skin and oily skin particularly well, and it is most commonly found in gentle toners and soothing exfoliators. It fits seamlessly into a daily routine because it works well with glycolic acid, vitamin C, and AHA blend glycolic and citric acids.

Clinical, Cosmetic and Investigational Dermatology, 2019The Australasian Journal of Dermatology, 1992Skin Research and Technology, 2023

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Gluconolactone toners

What reviewers say about popular gluconolactone products

The highlight reviewers mention most for each popular gluconolactone product on Lovi.

Gluconolactone exfoliators

Other gluconolactone products

Gluconolactone for dry skin

Gluconolactone for oily skin

Gluconolactone for combination skin

Gluconolactone for sensitive skin

What to combine gluconolactone with

IngredientTogetherHow to use them
Glycolic acid Works well Use them together in the same routine, applying glycolic acid first and gluconolactone second, because they work nicely as a team. Gluconolactone and glycolic acid
Vitamin C Works well Use them together in the same routine, applying vitamin C first and gluconolactone second, because mild acids help vitamin C absorb better. Gluconolactone and vitamin C
AHA blend glycolic and citric acids Works well Use them together in the same routine, applying the acid blend first and the gluconolactone second for gentle exfoliation. Gluconolactone and aha blend glycolic and citric acids
Salicylic acid Works well Use them together, applying salicylic acid first and gluconolactone second, because they make a gentle and hydrating exfoliating team. Gluconolactone and salicylic acid
Lactic acid Works well Use them together at night by applying lactic acid first and gluconolactone second, because the gluconolactone calms and hydrates skin. Gluconolactone and lactic acid
Mandelic acid Works well Use them together in the same routine, applying the mandelic acid first and the gluconolactone right after, because they balance each other out. Gluconolactone and mandelic acid
Hyaluronic acid Works well Use them together in the same routine, applying the mild acid first and then the hyaluronic acid, because they help each other hydrate and renew the skin. Gluconolactone and hyaluronic acid
Citric acid Works well Use them together in the same routine, applying the exfoliating acid first and the gentle smoothing acid right after. Gluconolactone and citric acid
Niacinamide Depends Use them together because niacinamide strengthens skin while gluconolactone smooths texture. Gluconolactone and niacinamide

From the ingredient rules behind the "Works well with" and "Don't mix with" notes on every product in the Lovi app.

Questions and answers

What does gluconolactone do for the skin?

Gluconolactone helps improve skin hydration, reduce sebum, and soothe mild acne or redness with fewer side effects. It also works as a gentle exfoliant that smooths skin texture and supports overall skin renewal.

The Australasian Journal of Dermatology, 1992Skin Research and Technology, 2023

How do you use gluconolactone?

You can use gluconolactone daily by applying it after glycolic, salicylic, lactic, or mandelic acid, or after vitamin C, to help hydrate and calm your skin.

Should you use gluconolactone in the morning or at night?

You can use gluconolactone in the morning or at night depending on your routine. When using it with lactic acid, apply it at night.

Can you use gluconolactone every day?

Yes, you can use gluconolactone every day as a gentle exfoliant and moisturizer. Studies show it helps improve skin hydration and reduce acne lesions over time with fewer side effects than traditional treatments.

The Australasian Journal of Dermatology, 1992Skin Research and Technology, 2023

Does gluconolactone cause purging or irritation?

Gluconolactone is unlikely to cause irritation because it is a very gentle, PHA exfoliating acid that hydrates the skin while smoothing texture.

The Australasian Journal of Dermatology, 1992Skin Research and Technology, 2023

Which skin types is gluconolactone best for?

Gluconolactone is best for dry, oily, combination, sensitive, and acne-prone skin, as well as skin with dark spots. For example, Lovi rates Kiehl's Hydro-Plumping Serum Concentrate as a Superior fit for dry skin and Biologique Recherche Lotion P50V as a Superior fit for oily skin.

Can you use gluconolactone with glycolic acid?

Yes, you can use gluconolactone and glycolic acid together in the same routine by applying glycolic acid first and gluconolactone second, because they work nicely as a team.

Research on gluconolactone

Behind this ingredient guide

Lovi checks every ingredient with brand-independent rules our dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update.

  • Nadia Kapleva, MS

    Nadia Kapleva, MS

    Co-founder, Medical Director

    Cosmetic chemist, cosmetologist, aesthetic products developer

  • Alexey Shagraev, PhD

    Alexey Shagraev, PhD

    Co-founder, CEO and CTO

    PhD in computer science, 3x US patent holder, ex-Google, ex-Yandex

  • Dr. Sofía Perea Pérez, MD, MSc

    Dr. Sofía Perea Pérez, MD, MSc

    Medical Board

    Aesthetic medicine practitioner, MSc in Longevity and Anti-Aging Medicine

  • Aishani Shah, MD

    Aishani Shah, MD

    Medical Board

    Specialist dermatologist, MBBS, MD, IFAAD

  • Asya Zubkova, MS

    Asya Zubkova, MS

    Medical Board

    Cosmetic chemist, SCS, IFSCC member

  • Hanna Kurets, MD

    Hanna Kurets, MD

    Medical Board, Medical Advisor

    Dermatology MD

  • Elina Nazarenko, MD

    Elina Nazarenko, MD

    Medical Board

    Dermatology and diagnostic consultant

  • Victoria Derkova, MS

    Victoria Derkova, MS

    Medical Board

    Cosmetic chemist, cosmetic development technologist

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