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Vitamin C and hexapeptide-9

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Vitamin C and hexapeptide-9: depends on the strength

Depends on the strength

Apply your vitamin C in the morning and your hexapeptide-9 at night, because mixing them together can make them less effective. Vitamin C and copper peptides clash and cancel out each other's anti-aging benefits. You can easily fix this by using them in separate routines or waiting ten minutes between applications.

Microneedle-Mediated Delivery of Copper Peptide Through Skin

Vitamin C products

Hexapeptide-9 products

Questions and answers

Can you use vitamin C and hexapeptide-9 together?

Whether you can use vitamin C and hexapeptide-9 together depends on the strength and specific type of ingredients you use. Pure vitamin C and copper-based peptides should be separated into different routines to avoid reducing their effectiveness, while pH-tolerant or stabilized peptide derivatives may pair well together.

Which goes first, vitamin C or hexapeptide-9?

Vitamin C and hexapeptide-9 should be used in separate routines to avoid oxidation and reduce peptide efficacy. Using them at different times of day helps prevent these ingredients from interacting on the skin.

Are vitamin C and hexapeptide-9 good for sensitive skin?

Using vitamin C and hexapeptide-9 together depends on the strength and type of ingredients used, as pure vitamin C and copper-based peptides should be separated to avoid reducing peptide efficacy. When using pH-tolerant peptide derivatives, they may coexist well in separate routines or specific formulations to help improve photoaged skin.

Experimental Dermatology, 2003

Research on vitamin C and hexapeptide-9

Behind this pairing advice

Lovi checks every pairing with brand-independent rules our dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update.

  • Nadia Kapleva, MS

    Nadia Kapleva, MS

    Co-founder, Medical Director

    Cosmetic chemist, cosmetologist, aesthetic products developer

  • Alexey Shagraev, PhD

    Alexey Shagraev, PhD

    Co-founder, CEO and CTO

    PhD in computer science, 3x US patent holder, ex-Google, ex-Yandex

  • Dr. Sof铆a Perea P茅rez, MD, MSc

    Dr. Sof铆a Perea P茅rez, MD, MSc

    Medical Board

    Aesthetic medicine practitioner, MSc in Longevity and Anti-Aging Medicine

  • Aishani Shah, MD

    Aishani Shah, MD

    Medical Board

    Specialist dermatologist, MBBS, MD, IFAAD

  • Asya Zubkova, MS

    Asya Zubkova, MS

    Medical Board

    Cosmetic chemist, SCS, IFSCC member

  • Hanna Kurets, MD

    Hanna Kurets, MD

    Medical Board, Medical Advisor

    Dermatology MD

  • Elina Nazarenko, MD

    Elina Nazarenko, MD

    Medical Board

    Dermatology and diagnostic consultant

  • Victoria Derkova, MS

    Victoria Derkova, MS

    Medical Board

    Cosmetic chemist, cosmetic development technologist

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