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Magnesium and hexapeptide-9

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Magnesium and hexapeptide-9: keep them apart

Keep them apart

Use them at different times of day, applying the peptide first and the magnesium later, because mixing them makes the peptide less effective. Unchelated metal ions like magnesium can bind to peptides and stop them from working properly on your skin. To fix this, you can separate when you use them or look for products that already include chelating agents.

Magnesium products

Hexapeptide-9 products

Questions and answers

Can you use magnesium and hexapeptide-9 together?

Keep magnesium and hexapeptide-9 apart in your skincare routine because unchelated metal ions may complex with peptides and reduce their biological activity.

Which goes first, magnesium or hexapeptide-9?

Keep magnesium and hexapeptide-9 apart in your routine because they may combine and reduce each other's effectiveness. You should use them at different times of the day.

Are magnesium and hexapeptide-9 good for sensitive skin?

No, you should keep magnesium and hexapeptide-9 apart in your routine because they may complex together and reduce their biological activity. While magnesium can help improve skin hydration and barrier function, it is best to use these ingredients separately.

Research on magnesium and hexapeptide-9

Behind this pairing advice

Lovi checks every pairing with brand-independent rules our dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update.

  • Nadia Kapleva, MS

    Nadia Kapleva, MS

    Co-founder, Medical Director

    Cosmetic chemist, cosmetologist, aesthetic products developer

  • Alexey Shagraev, PhD

    Alexey Shagraev, PhD

    Co-founder, CEO and CTO

    PhD in computer science, 3x US patent holder, ex-Google, ex-Yandex

  • Dr. Sof铆a Perea P茅rez, MD, MSc

    Dr. Sof铆a Perea P茅rez, MD, MSc

    Medical Board

    Aesthetic medicine practitioner, MSc in Longevity and Anti-Aging Medicine

  • Aishani Shah, MD

    Aishani Shah, MD

    Medical Board

    Specialist dermatologist, MBBS, MD, IFAAD

  • Asya Zubkova, MS

    Asya Zubkova, MS

    Medical Board

    Cosmetic chemist, SCS, IFSCC member

  • Hanna Kurets, MD

    Hanna Kurets, MD

    Medical Board, Medical Advisor

    Dermatology MD

  • Elina Nazarenko, MD

    Elina Nazarenko, MD

    Medical Board

    Dermatology and diagnostic consultant

  • Victoria Derkova, MS

    Victoria Derkova, MS

    Medical Board

    Cosmetic chemist, cosmetic development technologist

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