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Azelaic acid and hexapeptide-9

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Azelaic acid and hexapeptide-9: keep them apart

Keep them apart

Use azelaic acid and hexapeptide-9 at different times of day, applying the acid in the morning and the peptide at night, because the acid ruins the peptide. The strong acid breaks down the peptide, making it completely useless on your skin. To fix this, you can simply use the acid in your morning routine and the peptide at night.

Azelaic acid products

Hexapeptide-9 products

Questions and answers

Can you use azelaic acid and hexapeptide-9 together?

No, you should keep azelaic acid and hexapeptide-9 apart because low-pH acids can reduce peptide activity. Use them in separate steps or routines, such as separating your AM and PM applications.

Which goes first, azelaic acid or hexapeptide-9?

Keep azelaic acid and hexapeptide-9 apart by using them in separate steps or routines, such as AM and PM, because low-pH acids should not be combined directly with peptides.

Are azelaic acid and hexapeptide-9 good for sensitive skin?

Keep azelaic acid and hexapeptide-9 apart because low-pH acids should not be combined directly with peptides in the same routine, though they are suitable for sensitive skin when used separately.

Research on azelaic acid and hexapeptide-9

Behind this pairing advice

Lovi checks every pairing with brand-independent rules our dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update.

  • Nadia Kapleva, MS

    Nadia Kapleva, MS

    Co-founder, Medical Director

    Cosmetic chemist, cosmetologist, aesthetic products developer

  • Alexey Shagraev, PhD

    Alexey Shagraev, PhD

    Co-founder, CEO and CTO

    PhD in computer science, 3x US patent holder, ex-Google, ex-Yandex

  • Dr. Sof铆a Perea P茅rez, MD, MSc

    Dr. Sof铆a Perea P茅rez, MD, MSc

    Medical Board

    Aesthetic medicine practitioner, MSc in Longevity and Anti-Aging Medicine

  • Aishani Shah, MD

    Aishani Shah, MD

    Medical Board

    Specialist dermatologist, MBBS, MD, IFAAD

  • Asya Zubkova, MS

    Asya Zubkova, MS

    Medical Board

    Cosmetic chemist, SCS, IFSCC member

  • Hanna Kurets, MD

    Hanna Kurets, MD

    Medical Board, Medical Advisor

    Dermatology MD

  • Elina Nazarenko, MD

    Elina Nazarenko, MD

    Medical Board

    Dermatology and diagnostic consultant

  • Victoria Derkova, MS

    Victoria Derkova, MS

    Medical Board

    Cosmetic chemist, cosmetic development technologist

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