Purito vs REN Clean Skincare

Questions and answers

Research behind their key ingredients

• The effect of niacinamide on reducing cutaneous pigmentation and suppression of melanosome transfer

  Niacinamide · The British Journal of Dermatology, 2002

• Mechanistic Basis and Clinical Evidence for the Applications of Nicotinamide (Niacinamide) to Control Skin Aging and Pigmentation

  Niacinamide · Antioxidants, 2021

• Benefits of topical hyaluronic acid for skin quality and signs of skin aging: From literature review to clinical evidence

  Sodium hyaluronate · Dermatologic Therapy, 2022

• Topical use of dexpanthenol in skin disorders

  Panthenol · American Journal of Clinical Dermatology, 2002

• Anti-aging and brightening effects of a topical treatment containing vitamin C, vitamin E, and raspberry leaf cell culture extract: A split-face, randomized controlled trial

  Tocopherol, Ascorbic acid · Journal of Cosmetic Dermatology, 2020

• Skin-whitening and skin-condition-improving effects of topical oxidized glutathione: a double-blind and placebo-controlled clinical trial in healthy women

  Glutathione · Clinical, Cosmetic and Investigational Dermatology, 2014

• Moisturizing and Antiinflammatory Properties of Cosmetic Formulations Containing Centella asiatica Extract

  Centella asiatica extract, Madecassic acid, Madecassoside, Asiaticoside · Indian Journal of Pharmaceutical Sciences, 2016

• Topical Application of Centella asiatica in Wound Healing: Recent Insights into Mechanisms and Clinical Efficacy

  Centella asiatica extract · Pharmaceutics, 2024

• The effects of a topical gel containing chitosan, 0,2% chlorhexidine, allantoin and despanthenol on the wound healing process subsequent to impacted lower third molar extraction

  Allantoin · Medicina Oral, Patologia Oral Y Cirugia Bucal, 2016

• Alteration of barrier properties, stratum corneum ceramides and microbiome composition in response to lotion application on cosmetic dry skin

  Ceramide · Scientific Reports, 2022

• Ceramide 1 and ceramide 3 act synergistically on skin hydration and the transepidermal water loss of sodium lauryl sulfate-irritated skin

  Ceramide np · International Journal of Dermatology, 2008

• Effect of a topical antioxidant serum containing vitamin C, vitamin E, and ferulic acid after Q-switched 1064-nm Nd:YAG laser for treatment of environment-induced skin pigmentation

  Tocopherol, Ascorbic acid · Journal of Cosmetic Dermatology, 2020

• Injectable thermo-sensitive and wide-crack self-healing hydrogel loaded with antibacterial anti-inflammatory dipotassium glycyrrhizate for full-thickness skin wound repair

  Dipotassium glycyrrhizate · Acta Biomaterialia, 2022

• Anti-inflammatory activities of colloidal oatmeal (Avena sativa) contribute to the effectiveness of oats in treatment of itch associated with dry, irritated skin

  Avena sativa seed oat seed water seed · Journal of Drugs in Dermatology, 2015

• Green tea extract reduces induction of p53 and apoptosis in UVB-irradiated human skin independent of transcriptional controls

  Camellia sinensis leaf extract · Experimental Dermatology, 2009

• The clinical effect of glutathione on skin color and other related skin conditions: A systematic review

  Glutathione · Journal of Cosmetic Dermatology, 2019

• The 24-hour skin hydration and barrier function effects of a hyaluronic 1%, glycerin 5%, and Centella asiatica stem cells extract moisturizing fluid: an intra-subject, randomized, assessor-blinded study

  Glycerin, Madecassoside, Madecassic acid · Clinical, Cosmetic and Investigational Dermatology, 2017

• The Effects of a Standardized Extract of Centella asiatica on Postlaser Resurfacing Wound Healing on the Face: A Split-Face, Double-Blind, Randomized, Placebo-Controlled Trial

  Madecassoside, Asiaticoside, Madecassic acid · Journal of Alternative and Complementary Medicine, 2020

• Randomized controlled study for the anti-aging effect of human adipocyte-derived mesenchymal stem cell media combined with niacinamide after laser therapy

  Niacinamide · Journal of Cosmetic Dermatology, 2021

• A new topical panthenol-containing emollient: Results from two randomized controlled studies assessing its skin moisturization and barrier restoration potential, and the effect on skin microflora

  Panthenol · The Journal of Dermatological Treatment, 2017

• Senomorphic activity of a combination of niacinamide and hyaluronic acid: correlation with clinical improvement of skin aging

  Niacinamide · Scientific Reports, 2024

• Preparation of novel apigenin-enriched, liposomal and non-liposomal, antiinflammatory topical formulations as substitutes for corticosteroid therapy

  Extracts flower · Phytotherapy Research, 2011

• Adenosine-loaded dissolving microneedle patches to improve skin wrinkles, dermal density, elasticity and hydration

  Adenosine · International Journal of Cosmetic Science, 2018

• Efficacy of a topical gel containing chitosan, chlorhexidine, allantoin and dexpanthenol for pain and inflammation control after third molar surgery: A randomized and placebo-controlled clinical trial

  Allantoin, Panthenol · Medicina Oral, Patologia Oral Y Cirugia Bucal, 2020

• Topical glutathione amino acid precursors protect skin against environmental and oxidative stress

  Glutathione · Journal of the European Academy of Dermatology and Venereology, 2024

• Systematic Study of Paeonol/Madecassoside Co-Delivery Nanoemulsion Transdermal Delivery System for Enhancing Barrier Repair and Anti-Inflammatory Efficacy

  Centella asiatica extract, Madecassoside · Molecules, 2023

• Double-blind, randomized, placebo-controlled study of a lotion containing triethyl citrate and ethyl linoleate in the treatment of acne vulgaris

  Triethyl citrate · The British Journal of Dermatology, 2007

• A Lipid Mixture Enriched by Ceramide NP with Fatty Acids of Diverse Chain Lengths Contributes to Restore the Skin Barrier Function Impaired by Topical Corticosteroid

  Ceramide np · Skin Pharmacology and Physiology, 2022

• Clay jojoba oil facial mask for lesioned skin and mild acne--results of a prospective, observational pilot study

  Jojoba seed oil · Forschende Komplementarmedizin, 2012

• Effects of 1,3-propanediol associated, or not, with butylene glycol and/or glycerol on skin hydration and skin barrier function

  Propanediol · International Journal of Cosmetic Science, 2024

• Antiacne and antiblotch activities of a formulated combination of Aloe barbadensis leaf powder, Garcinia mangostana peel extract, and Camellia sinensis leaf extract

  Camellia sinensis leaf extract · Clinical, Cosmetic and Investigational Dermatology, 2019

• Administration of skin care regimens containing β-glucan for skin recovery after fractional laser therapy: A split-face, double-blinded, vehicle-controlled study

  Beta-glucan · Journal of Cosmetic Dermatology, 2021

• Effect of a botanical cleansing lotion on skin sebum and erythema of the face: A randomized controlled blinded half-side comparison

  Salix nigra bark extract willow bark extract · Journal of Cosmetic Dermatology, 2019

• Anti-Inflammatory Effect of a Novel Topical Herbal Composition (VEL-091604) Consisting of Gentian Root, Licorice Root and Willow Bark Extract

  Salix nigra bark extract willow bark extract · Planta Medica, 2019

• An evaluation of the effect of a topical product containing salicin on the visible signs of human skin aging

  Salix nigra bark extract willow bark extract · Journal of Cosmetic Dermatology, 2010

• Two-phase delivery using a horse oil and adenosine-loaded dissolving microneedle patch for skin barrier restoration, moisturization, and wrinkle improvement

  Adenosine · Journal of Cosmetic Dermatology, 2019

• Development of solid lipid microparticles (SLMs) containing asiatic acid for topical treatment of acne: Characterization, stability, in vitro and in vivo anti-acne assessment

  Asiatic acid · International Journal of Pharmaceutics, 2024

• Evaluation of the Efficacy and Safety of a Panthenol-Enriched Mask for Skin Barrier Recovery After Facial Laser Treatment: Results of a Double-Blind Randomized Controlled Study

  Panthenol · Journal of Cosmetic Dermatology, 2025

• Propanediol (and) Caprylic Acid (and) Xylitol as a New Single Topical Active Ingredient against Acne: In Vitro and In Vivo Efficacy Assays

  Propanediol · Molecules, 2021

• Dead Sea minerals: New findings on skin and the biology beyond

  Deep sea water · Experimental Dermatology, 2019

• Effect of an Emollient Emulsion Containing 15.0% of Caprylic/Capric Triglyceride on the Urocanic Acid of the Stratum Corneum

  Caprylic capric triglyceride · Life, 2023

• Translational Evaluation of a Disodium Adenosine Monophosphate (AMP2Na)-Based Topical Formulation for Physiology-Aligned Skin Rejuvenation: Integrated In Vitro, Ex Vivo, and Clinical Evidence

  Adenosine · International Journal of Molecular Sciences, 2026

• Functional properties and skin care effects of sodium trehalose sulfate

  Trehalose · Skin Research and Technology, 2024

• Evaluation of additive effects of hydrolyzed jojoba (Simmondsia chinensis) esters and glycerol: a preliminary study

  Hydrolyzed jojoba esters · Journal of Cosmetic Dermatology, 2008

• Noninvasive Monitoring of Palmitoyl Hexapeptide-12 in Human Skin Layers: Mechanical Interaction with Skin Components and Its Potential Skincare Benefits

  Palmitoyl hexapeptide-12 · ACS Applied Bio Materials, 2025

• Efficacy of a Topical Formulation on Skin Hydration and Barrier Function in Individuals With Xerosis: A 28-Day Randomized, Split-Leg, Untreated-Controlled Trial

  Dipotassium glycyrrhizate · Journal of Cosmetic Dermatology, 2026

• Targeting Circadian Rhythm for the Regulation of Skin Collagen Metabolism

  Palmitoyl tripeptide-1 · Journal of Cosmetic Dermatology, 2026

• Low-temperature extracted Portulaca oleracea L. as a functional ingredient in facial masks for photorejuvenation of sensitive skin

  Portulaca oleracea extract · Cutaneous and Ocular Toxicology, 2025

Behind this comparison

Lovi compares products by their fit scores, calculated from the full ingredient list with brand-independent rules our dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update.