Lancôme Génifique Ultimate for combination skin
Bifida Lysate Ferment
Hyaluronic Acid
Glycerin
Tocopheryl Acetate
Adenosine
Average
- HighCombination Skin Fit
- AverageEffectiveness
- HighSafety
Works for combination skin; other serums fit it better.
This fit is calculated for the concerns frequently associated with combination skin: an oily T-zone, enlarged pores, and dry cheeks. For scores and recommendations based on your full skin profile, including your 12D face scan results and any goals or preferences you have, please use the Lovi app.
Page built Nov 8, 2026How the Fit score works
Lovi Assistant explains
- Offers moderate benefits for your combination skin, as bifida ferment lysate and hyaluronic acid enhance barrier resilience and hydration, but it lacks targeted ingredients for your primary concern of oily shine.
- The formula is safe for your combination skin, with no harsh ingredients that would cause irritation.
- While it provides general skincare benefits, the formulation does not specifically address oil control for your oily shine concern.
How to apply
- Use your serum as part of your PM routine. Start using it 3 times a week and move to daily use if your skin likes it.
- Apply the serum after cleansing and toner, and right before your moisturizer.
- Gently press 2-3 drops of the serum into your skin and wait a minute ⏳for it to soak in.
- Apply the serum on clean and dry skin since your skin is not sensitive.
- Always do a patch test before using the serum for the first time, and avoid the eye area .
People Say
★4.6Overall rating based on 1.2k+ reviewsBased on a very large amount of data, users love this serum's lightweight, silky texture that absorbs quickly, leaving skin feeling soothed, hydrated, and plump without any stickiness. While many experience smoother skin and a strengthened barrier, some note that anti-aging effects like wrinkle reduction are subtle and require consistent, long-term use. The high price point is frequently mentioned as a drawback.
Highlights
Lightweight texture Mostly Mentioned
- “absorbs almost instantly”
- “lightweight and silky”
- “no sticky residue”
- “glides effortlessly”
Hydration and plumping Often Mentioned
- “skin felt more plump”
- “luxuriously hydrating”
- “healthy luminous glow”
- “dewy and fresh”
Soothing and calming Often Mentioned
- “instantly soothed my skin”
- “redness has decreased”
- “calming on contact”
- “great for sensitive skin”
High price point Often Mentioned
- “bit of a splurge”
- “price is steep”
- “hard to justify cost”
- “expensive for the amount”
Improves skin texture Sometimes Noted
- “pores looked more refined”
- “baby-soft skin”
- “texture looked refined”
- “smoother feeling skin”
Makeup compatibility Sometimes Noted
- “layers beautifully under makeup”
- “helps makeup apply better”
- “works well under foundation”
Subtle results Sometimes Noted
- “didn't notice much change in wrinkles”
- “results feel subtle”
- “needs consistent use”
- “not an overnight fix”
Dropper design Rarely Noted
- “struggled to open cap”
- “dropper is finicky”
- “hard to get last drops”
Pilling issues Rarely Noted
- “pilling like dead skin”
- “pills if not fully absorbed”
- “rubbed off when layering”
Unpleasant scent Rarely Noted
- “can't get used to the smell”
- “distinctive fermented scent”
- “smell is a bit unusual”
Sources: lovi.care, sephora.com.au, hometesterclub.com, ult.com, beautycrew.com.au, dailyvanity.sg, and more
Questions and answers
How well does Lancôme Génifique Ultimate Serum work for combination skin?
Lancome Genifique Ultimate Serum works moderately well for combination skin by boosting hydration and strengthening the skin barrier, though it lacks targeted ingredients for oily shine. A product of this type needs ingredients like niacinamide, zinc PCA, or propolis to regulate oiliness and balance combination skin.
Dermatologic Therapy, 2022Journal of Cosmetic Dermatology, 2023
Which ingredients make this serum a good fit for combination skin?
Bifida ferment lysate and hyaluronic acid make this serum a fit by strengthening your skin barrier and boosting hydration. However, because it lacks oil-controlling ingredients for oily shine, a treatment for combination skin needs to include ingredients like niacinamide, zinc PCA, and propolis to regulate oiliness.
Journal of Cosmetic Dermatology, 2023Dermatologic Therapy, 2022
What does Bifida Ferment Lysate do for combination skin?
Bifida Ferment Lysate helps strengthen the skin barrier and calm irritation, making it a good fit for combination skin that is prone to sensitivity. This ingredient works by supporting the skin defenses, keeping moisture locked in, and helping to reduce redness.
Journal of Cosmetic Dermatology, 2023Experimental Dermatology, 2010
What does Hyaluronic Acid do for combination skin?
Hyaluronic acid is a great fit for combination skin because it quenches dry areas with a boost of hydration while keeping oily zones balanced. Regular use helps smooth out fine lines and makes your skin feel soft and plump without causing irritation.
Dermatology and Therapy, 2021Journal of Drugs in Dermatology, 2011
Where does this serum go in a skincare routine for combination skin?
This treatment serum goes in the evening routine after cleansing and before moisturizing, as putting it then keeps your routine simple and avoids sun exposure concerns. A product of this type needs balancing ingredients like niacinamide or clay to help control oily shine and improve your combination skin.
Can I use this serum with retinol, and in what order?
You can use this treatment alongside retinol by applying the treatment first and following with your retinol. The formula is safe for combination skin and is unlikely to cause irritation.
How often should I use this serum?
This treatment works well in the evening for your combination skin to keep it hydrated and calm. To properly care for combination skin, a product of this type needs added oil-control ingredients to help manage oily shine.
Clinical, Cosmetic and Investigational Dermatology, 2023Journal of Cosmetic Dermatology, 2023
Can this serum clog pores, cause breakouts or purging for combination skin?
Lancôme Génifique Ultimate is unlikely to clog pores or cause breakouts for combination skin because its formula has no harsh ingredients that cause irritation. However, since it does not target oily shine, combination skin prone to breakouts still needs lightweight, oil-controlling ingredients like salicylic acid or niacinamide to help keep pores clear.
Is this serum fragrance-free and alcohol-free?
It contains fragrance (parfum) and drying alcohol (alcohol denat).
What the research says
Topical hyaluronic acid filler serum combined with Botulinum toxin type A lengthened the duration of the toxin's effect in reducing wrinkles compared to Botulinum toxin type A alone.
Dermatologic Therapy, 2022Topical application of Bifida Ferment Lysate strengthens the skin barrier function by upregulating barrier and antimicrobial peptide genes, exhibiting strong antioxidant properties, and decreasing inflammatory cytokine secretion in vitro.
Journal of Cosmetic Dermatology, 2023Optimized transfersomes loaded with epigallocatechin-3-gallate and hyaluronic acid increased cell viability while reducing lipid peroxidation, intracellular ROS, and MMP expression in HaCaT cells, and exhibited higher skin permeation and deposition compared to plain EGCG.
Drug Delivery, 2017Topical application of 0.1% hyaluronic acid formulations of different molecular weights led to significant improvements in skin hydration and elasticity, with low-molecular-weight formulations also significantly reducing wrinkle depth in seventy-six female subjects compared to a vehicle control.
Journal of Drugs in Dermatology, 2011Topical application of hyaluronic acid in conjunction with free gingival graft significantly reduced donor site postoperative pain until day 7 compared to normal saline, with no significant differences in graft dimensions or patient satisfaction.
Clinical Oral Investigations, 2022Treatment with a hyaluronic acid-containing mouth rinse or topical gel led to significant lesion reduction, pain relief, and normalization of lesion color in adult patients with minor recurrent aphthous stomatitis, with the gel formulation showing an earlier healing onset at 3 days.
BMC Oral Health, 2019A single application of a moisturizing fluid containing hyaluronic acid 1%, glycerin 5%, and Centella asiatica stem cells extract significantly increased skin hydration by 29% and reduced transepidermal water loss at 24 hours compared to baseline and an untreated control site in twenty healthy women.
Clinical, Cosmetic and Investigational Dermatology, 2017The emollient V0034CR significantly reduced TEWL compared to vehicle and vehicle plus glycerol, and significantly increased corneometry scores compared to vehicle and vehicle plus petrolatum in healthy volunteers with dry skin, demonstrating combined barrier function improvement from petrolatum and hydration improvement from glycerol.
Journal of Cosmetic Dermatology, 2020Ten days of treatment with a cream containing 20% glycerin significantly increased skin hydration measured by corneometer values in 17 healthy volunteers compared to a placebo cream, but showed no influence on transepidermal water loss or skin sensitivity to an irritating surfactant.
International Journal of Cosmetic Science, 2001Topical application of an antioxidant serum containing 15% ascorbic acid, 0.5% ferulic acid, and 1% tocopherol prevented particulate matter-induced degradation of extracellular matrix components, inflammation, and oxidative stress in the skin of 15 female volunteers compared to untreated controls.
Journal of Cosmetic Dermatology, 2025Dermatological products containing d-alpha tocopheryl acetate showed non-comedogenic potential with less than a 50% increase in microcomedones in 12 healthy male subjects compared to octyl palmitate.
Contemporary Clinical Trials Communications, 2021Topical application of an antioxidant mix containing 15% ascorbic acid, 0.5% ferulic acid, and 1% tocopherol prevented PM and UV-induced skin barrier perturbation, lipid peroxidation, inflammatory markers, MMP9 activation, and Type I collagen loss in 15 healthy females compared to untreated exposed skin.
Journal of Cosmetic Dermatology, 2024Topical adenosine treatment significantly increased the anagen hair growth rate and thick hair rate compared to placebo in Japanese women with female pattern hair loss over 12 months.
The Journal of Dermatology, 2008Topical application of a disodium adenosine monophosphate-based formulation reduced wrinkles and hyperpigmentation while improving hydration, barrier function, skin lifting, and epidermal turnover in female participants.
International Journal of Molecular Sciences, 2026Adenosine and cordycepin stimulate the Wnt/beta-catenin signaling pathway through adenosine receptor and PKA activation, promoting cell proliferation, migration, and growth factor secretion in cultured dermal fibroblasts.
International Journal of Molecular Sciences, 2021
Why other serums fit combination skin better
Niacinamide and ferulic acid incorporated in a stable multiple emulsion successfully reduced melanin, sebum, and skin erythema while improving skin elasticity and hydration in human skin compared to a placebo.
BioMed Research International, 2022A panthenol-enriched mask improved skin hydration, regulated sebum, and reduced redness and TEWL across dry sensitive, oily sensitive, and oily acne skin subgroups with excellent tolerance and no adverse reactions.
Journal of Cosmetic Dermatology, 2024
Ingredients
Water, Bifida Lysate Ferment, Glycerin, Dimethicone, Alcohol Denat, Hydroxyethylpiperazine Ethane Sulfonic Acid, Hyaluronic Acid, Tocopheryl Acetate, Adenosine, Phenoxyethanol, Ammonium Polyacryloyldimethyl Taurate, Sodium Hydroxide, Caprylyl Glycol, Disodium Edta, Citric Acid, Xanthan Gum, Polysorbate 20, Parfum
Behind this fit score
Lovi calculates every fit score from the full ingredient list with brand-independent rules our dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update.
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Co-founder, Medical Director
Cosmetic chemist, cosmetologist, aesthetic products developer
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Co-founder, CEO and CTO
PhD in computer science, 3x US patent holder, ex-Google, ex-Yandex
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Dr. Sofía Perea Pérez, MD, MSc
Medical Board
Aesthetic medicine practitioner, MSc in Longevity and Anti-Aging Medicine
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Medical Board
Specialist dermatologist, MBBS, MD, IFAAD
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Medical Board
Cosmetic chemist, SCS, IFSCC member
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Medical Board, Medical Advisor
Dermatology MD
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Elina Nazarenko, MD
Medical Board
Dermatology and diagnostic consultant
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Victoria Derkova, MS
Medical Board
Cosmetic chemist, cosmetic development technologist
How does it fit your skin?
Scan your face, then any product: Lovi shows how well it fits you and what fits even better.