Lancôme vs REN Clean Skincare

Questions and answers

Research behind their key ingredients

• Benefits of topical hyaluronic acid for skin quality and signs of skin aging: From literature review to clinical evidence

  Hyaluronic acid, Sodium hyaluronate · Dermatologic Therapy, 2022

• Topical use of dexpanthenol in skin disorders

  Panthenol · American Journal of Clinical Dermatology, 2002

• Treatment of acne with a combination of propolis, tea tree oil, and Aloe vera compared to erythromycin cream: two double-blind investigations

  Aloe barbadensis extract · Clinical Pharmacology, 2018

• Ceramide 1 and ceramide 3 act synergistically on skin hydration and the transepidermal water loss of sodium lauryl sulfate-irritated skin

  Ceramide np · International Journal of Dermatology, 2008

• The 24-hour skin hydration and barrier function effects of a hyaluronic 1%, glycerin 5%, and Centella asiatica stem cells extract moisturizing fluid: an intra-subject, randomized, assessor-blinded study

  Glycerin · Clinical, Cosmetic and Investigational Dermatology, 2017

• A new topical panthenol-containing emollient: Results from two randomized controlled studies assessing its skin moisturization and barrier restoration potential, and the effect on skin microflora

  Panthenol · The Journal of Dermatological Treatment, 2017

• A Double-Blinded, Randomized, Vehicle-Controlled Study of the Efficacy of Moisturizer Containing Licochalcone A, Decanediol, L-Carnitine, and Salicylic Acid for Prevention of Acne Relapse in Asian Population

  Salicylic acid · BioMed Research International, 2020

• Stable Ozonides with Vitamin E Acetate versus Corticosteroid in the Treatment of Lichen Sclerosus in Foreskin: Evaluation of Effects on Inflammation

  Tocopheryl acetate · Urologia Internationalis, 2019

• Adenosine-loaded dissolving microneedle patches to improve skin wrinkles, dermal density, elasticity and hydration

  Adenosine · International Journal of Cosmetic Science, 2018

• Double-blind, randomized, placebo-controlled study of a lotion containing triethyl citrate and ethyl linoleate in the treatment of acne vulgaris

  Triethyl citrate · The British Journal of Dermatology, 2007

• The pivotal role of Bifida Ferment Lysate on reinforcing the skin barrier function and maintaining homeostasis of skin defenses in vitro

  Bifida lysate ferment · Journal of Cosmetic Dermatology, 2023

• Efficacy of a multitargeted, salicylic acid-based dermocosmetic cream compared to benzoyl peroxide 5% in Acne vulgaris: Results from a randomized study

  Salicylic acid · Journal of Cosmetic Dermatology, 2024

• A Lipid Mixture Enriched by Ceramide NP with Fatty Acids of Diverse Chain Lengths Contributes to Restore the Skin Barrier Function Impaired by Topical Corticosteroid

  Ceramide np · Skin Pharmacology and Physiology, 2022

• Preparation and evaluation of benzalkonium chloride hand sanitizer as a potential alternative for alcohol-based hand gels

  Benzalkonium chloride · Saudi Pharmaceutical Journal, 2021

• Spent Yeast Waste Streams as a Sustainable Source of Bioactive Peptides for Skin Applications

  Yeast · International Journal of Molecular Sciences, 2023

• A Rose Extract Protects the Skin against Stress Mediators: A Potential Role of Olfactory Receptors

  Rosa centifolia flower extract · Molecules, 2020

• Topical application of jojoba (Simmondsia chinensis L.) wax enhances the synthesis of pro-collagen III and hyaluronic acid and reduces inflammation in the ex-vivo human skin organ culture model

  Jojoba seed oil · Frontiers in Pharmacology, 2024

• Clinical evaluation of the efficacy of a facial serum containing dioic acid, glycolic acid, salicylic acid, LHA, citric acid, and HEPES in treating post-inflammatory hyperchromia and controlling oily skin in patients with acne vulgaris

  Capryloyl salicylic acid · Journal of Cosmetic Dermatology, 2021

• Safety assessment of cyclomethicone, cyclotetrasiloxane, cyclopentasiloxane, cyclohexasiloxane, and cycloheptasiloxane

  Cyclopentasiloxane · International Journal of Toxicology, 2011

• Clinical tolerance and efficacy of capryloyl salicylic acid peel compared to a glycolic acid peel in subjects with fine lines/wrinkles and hyperpigmented skin

  Capryloyl salicylic acid · Journal of Cosmetic Dermatology, 2008

• Effect of a botanical cleansing lotion on skin sebum and erythema of the face: A randomized controlled blinded half-side comparison

  Salix nigra bark extract willow bark extract · Journal of Cosmetic Dermatology, 2019

• Anti-Inflammatory Effect of a Novel Topical Herbal Composition (VEL-091604) Consisting of Gentian Root, Licorice Root and Willow Bark Extract

  Salix nigra bark extract willow bark extract · Planta Medica, 2019

• An evaluation of the effect of a topical product containing salicin on the visible signs of human skin aging

  Salix nigra bark extract willow bark extract · Journal of Cosmetic Dermatology, 2010

• Two-phase delivery using a horse oil and adenosine-loaded dissolving microneedle patch for skin barrier restoration, moisturization, and wrinkle improvement

  Adenosine · Journal of Cosmetic Dermatology, 2019

• Effects of Investigational Moisturizers on the Skin Barrier and Microbiome following Exposure to Environmental Aggressors: A Randomized Clinical Trial and Ex Vivo Analysis

  Yeast extract · Journal of Clinical Medicine, 2023

• Design and in vivo evaluation of emulgel formulations including green tea extract and rose oil

  Rosa damascena oil flower, The rose essential oil · Acta Pharmaceutica, 2013

• Influence of vitamin E acetate on stratum corneum hydration

  Tocopheryl acetate · Arzneimittel-Forschung, 1998

• Safety of a preservative system containing 1,2-hexanediol and caprylyl glycol

  Caprylyl glycol · Cutaneous and Ocular Toxicology, 2009

• Evaluation of the Efficacy and Safety of a Panthenol-Enriched Mask for Skin Barrier Recovery After Facial Laser Treatment: Results of a Double-Blind Randomized Controlled Study

  Panthenol · Journal of Cosmetic Dermatology, 2025

• Histometric assessment of the age-related skin response to 2-hydroxy-5-octanoyl benzoic acid

  Capryloyl salicylic acid · Skin Pharmacology and Applied Skin Physiology, 1998

• Translational Evaluation of a Disodium Adenosine Monophosphate (AMP2Na)-Based Topical Formulation for Physiology-Aligned Skin Rejuvenation: Integrated In Vitro, Ex Vivo, and Clinical Evidence

  Adenosine · International Journal of Molecular Sciences, 2026

• Nanostructured Lipid Carrier Based Gel Containing α-Tocopherol and α-Tocopheryl Acetate for Synergistic Cutaneous Antiaging Efficacy

  Tocopheryl acetate · Scientific Reports, 2025

• A Double-Blind, 12-Week Study to Evaluate the Antiaging Efficacy of a Cream Containing the NFκB Inhibitor 4-Hexyl-1, 3-Phenylenediol and Ascorbic Acid-2 Glucoside in Adult Females

  Ascorbyl glucoside · Journal of Drugs in Dermatology, 2016

• Effect of an Emollient Emulsion Containing 15.0% of Caprylic/Capric Triglyceride on the Urocanic Acid of the Stratum Corneum

  Caprylic capric triglyceride · Life, 2023

• Safety assessment on comedogenicity of dermatological products containing d-alpha tocopheryl acetate in Asian subjects: A double-blind randomized controlled trial

  Tocopheryl acetate · Contemporary Clinical Trials Communications, 2021

• Treatment with Ascorbyl Glucoside-Arginine Complex Ameliorates Solar Lentigos

  Ascorbyl glucoside · International Journal of Molecular Sciences, 2024

• Impact of Hydrocolloid Dressing and Moisturizing Cream as Facial Skin Protectants Among Health Care Workers

  Dimethicone · Military Medicine, 2024

• Clinical Efficacy of a Flavo-Proxylane Topical Regimen Pre- and Post-ultrasound Procedure for Subjects Undergoing Glucagon-Like Peptide 1 (GLP-1) Receptor Agonist Therapy

  Hydroxypropyl tetrahydropyrantriol · Dermatology and Therapy, 2026

• Skin moisturization by hydrogenated polyisobutene--quantitative and visual evaluation

  Hydrogenated polyisobutene · Journal of Cosmetic Science, 2009

• The Application of a Formulation Containing Hydroxypropyl Tetrahydropyrantriol and Niacinamide to Augment Anti-aging Benefits in a Double-blind, Randomized Nonablative Laser Treatment Study

  Hydroxypropyl tetrahydropyrantriol · The Journal of Clinical and Aesthetic Dermatology, 2025

Behind this comparison

Lovi compares products by their fit scores, calculated from the full ingredient list with brand-independent rules our dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update.