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NIOD Modulating Glucosides for combination skin

Rated by Lovi · Unbiased, science-based skincare AI trained on real user outcomes

NIOD Modulating Glucosides

High

  • HighCombination Skin Fit
  • HighEffectiveness
  • HighSafety

One of the best serums for combination skin.

This fit is calculated for the concerns frequently associated with combination skin: an oily T-zone, enlarged pores, and dry cheeks. For scores and recommendations based on your full skin profile, including your 12D face scan results and any goals or preferences you have, please use the Lovi app.

Page built Nov 8, 2026How the Fit score works

Lovi Assistant explains

  • Highly suitable for your combination skin, this formulation leverages Squalane and Glycerin to provide balanced hydration, addressing both oily and dry areas effectively.
  • The presence of Bisabolol and Epigallocatechin Gallatyl Glucoside offers excellent soothing and redness reduction, while Tasmannia Lanceolata Leaf Extract further calms inflammation.
  • The safety profile is excellent, with no risks of irritation due to the absence of harsh ingredients and the inclusion of soothing components.

How to apply

  • Use your serum as part of your PM routine. Start using it 3 times a week and move to daily use if your skin likes it.
  • Apply the serum after cleansing and toner, and right before your moisturizer.
  • Gently press 2-3 drops of the serum into your skin and wait a minute ⏳for it to soak in.
  • Apply the serum on clean and dry skin since your skin is not sensitive.
  • Always do a patch test before using the serum for the first time, and avoid the eye area .

People Say

★4.8Overall rating based on 400+ reviews

This serum is highly praised for its ability to calm sensitive, reactive, and irritated skin, with users frequently reporting significant improvements in redness, stinging, and compromised skin barriers. It is a popular choice for those recovering from aesthetic treatments or harsh active ingredients. Some users with normal skin may find the benefits less noticeable or the texture slightly heavy.

Highlights

  • Calms sensitive skin Mostly Mentioned
    • “Like medicine to irritated skin.”
    • “Great for sensitive, reactive skin.”
    • “Helps quiet sensations of stinging and itching.”
  • Reduces skin redness Often Mentioned
    • “Visibly reduced redness for a more even tone.”
    • “Calms redness and stinging.”
    • “It really did wonders in soothing skin and reducing redness.”
  • Buffers active irritation Sometimes Noted
    • “Helps minimise the side effects of retinoids.”
    • “Buffers retinoid/acid irritation.”
    • “Reason my skin had been so calm while I was on Roaccutane.”
  • Strengthens skin barrier Sometimes Noted
    • “Saved my skin barrier from beyond hope.”
    • “Strengthens skin barrier integrity over time.”
    • “Especially helpful when my barrier is compromised.”
  • Inconvenient packaging Sometimes Noted
    • “Dropper bottle is messy to use.”
    • “Not my favorite type of packaging.”
    • “Why doesn't it come with a pump?”
  • Subtle for normal skin Sometimes Noted
    • “If you have normal skin, benefits may not be apparent.”
    • “I did not notice any improvement.”
  • Can cause breakouts Rarely Noted
    • “It broke me out almost instantly.”
    • “Heavy going on my face.”
  • Unappealing scent Rarely Noted
    • “Strong nutty scent.”
    • “A bit like paint.”
    • “Has a bit of a medicinal smell.”

Sources: lovi.care, niod.com, skinsort.com, dermapproved.com, drrachelho.com, daniellesbeautyblog.com, and more

Questions and answers

What makes NIOD Modulating Glucosides a great fit for combination skin?

This treatment is a great fit for your combination skin because it uses squalane and glycerin to deliver balanced hydration to both oily and dry areas. It also includes bisabolol and other soothing ingredients to calm redness and irritation with a very low risk of issues.

Clinical, Cosmetic and Investigational Dermatology, 2017

Which ingredients make this serum a good fit for combination skin?

This serum is a great fit for combination skin because it uses squalane and glycerin to give balanced hydration to both oily and dry areas. It also includes bisabolol and epigallocatechin gallatyl glucoside, which help soothe the skin and reduce redness without any irritation.

Clinical, Cosmetic and Investigational Dermatology, 2017

What do Glucosides do for combination skin?

Glucosides help wash combination skin gently without leaving oily areas greasy or dry patches feeling tight. They clean the surface while keeping the skin barrier calm and balanced. A cleanser of this type needs mild surfactants and moisturizing agents to protect skin hydration.

Dermatologic Therapy, 2004Dermatologic Therapy, 2004

What does Squalane do for combination skin?

Squalane helps keep combination skin soft and smooth by locking in moisture without feeling heavy or greasy. It supports the skin barrier and provides lightweight hydration that works well for both dry and oily areas.

Skin Health and Disease, 2024Journal of Nanobiotechnology, 2025

Where does this serum go in a skincare routine for combination skin?

This treatment goes in the evening routine after cleansing and before moisturizing, which keeps the application simple and safe around sun exposure. It helps provide balanced hydration for oily and dry areas while soothing the skin without causing irritation.

Can I use this serum with retinol, and in what order?

You can use this treatment alongside retinol by applying this serum first and following it with your retinol product. This helps keep your skin calm and lowers the chance of irritation from stronger ingredients.

Journal of Cosmetic Dermatology, 2024

How often should I use this serum?

This treatment is used in the evening as part of your routine. It is a great fit for combination skin because it provides balanced hydration for both oily and dry areas while soothing redness.

Can this serum clog pores, cause breakouts or purging for combination skin?

NIOD Modulating Glucosides is unlikely to cause breakouts on combination skin, as it has a very low complaint rate and a high suitability for this skin type. The formulation features balanced hydrating ingredients like squalane and glycerin alongside soothing components, maintaining a very safe profile without harsh ingredients.

Clinical, Cosmetic and Investigational Dermatology, 2017

Is this serum fragrance-free and alcohol-free?

It has no drying alcohol and contains fragrance (benzyl alcohol).

What the research says

Ingredients

Water, Squalane, Isodecyl Neopentanoate, Glycerin, Caprylic Capric Triglyceride, Pentylene Glycol, Propanediol, Hexyldecanol, Bisabolol, Butylene Glycol, Epigallocatechin Gallatyl Glucoside, Rosmarinyl Glucoside, Caffeyl Glucoside, Gallyl Glucoside, Tetrasodium Tetracarboxymethyl Naringeninchalcone, Hydroxymethoxyphenyl Decanone, 4-T-Butylcyclohexanol, Cetylhydroxyproline Palmitamide, Hydroxyphenyl Propamidobenzoic Acid, Palmitoyl Tripeptide-8, Superoxide Dismutase, Sodium Pca, Pca, Arginine, Glycine, Alanine, Serine, Valine, Isoleucine, Proline, Threonine, Histidine, Phenylalanine, Aspartic Acid, Sodium Lactate, Mirabilis Jalapa Callus Extract, Tasmannia Lanceolata Leaf Extract Fruit, Zingiber Officinale Root Extract, Curculigo Orchioides Root Extract, Isochrysis Galbana Extract, Brassica Campestris Sterols, Stearic Acid, Dextran, Isoceteth-20, Polyacrylate Crosspolymer-6, Xanthan Gum, Tocopherol, Propyl Gallate, Tromethamine, Dehydroacetic Acid, 1,2-Hexanediol, Benzyl Alcohol, Phenoxyethanol, Caprylyl Glycol

Behind this fit score

Lovi calculates every fit score from the full ingredient list with brand-independent rules our dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update.

  • Nadia Kapleva, MS

    Nadia Kapleva, MS

    Co-founder, Medical Director

    Cosmetic chemist, cosmetologist, aesthetic products developer

  • Alexey Shagraev, PhD

    Alexey Shagraev, PhD

    Co-founder, CEO and CTO

    PhD in computer science, 3x US patent holder, ex-Google, ex-Yandex

  • Dr. Sofía Perea Pérez, MD, MSc

    Dr. Sofía Perea Pérez, MD, MSc

    Medical Board

    Aesthetic medicine practitioner, MSc in Longevity and Anti-Aging Medicine

  • Aishani Shah, MD

    Aishani Shah, MD

    Medical Board

    Specialist dermatologist, MBBS, MD, IFAAD

  • Asya Zubkova, MS

    Asya Zubkova, MS

    Medical Board

    Cosmetic chemist, SCS, IFSCC member

  • Hanna Kurets, MD

    Hanna Kurets, MD

    Medical Board, Medical Advisor

    Dermatology MD

  • Elina Nazarenko, MD

    Elina Nazarenko, MD

    Medical Board

    Dermatology and diagnostic consultant

  • Victoria Derkova, MS

    Victoria Derkova, MS

    Medical Board

    Cosmetic chemist, cosmetic development technologist

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