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Medik8 Oxy-R Peptides for sensitive skin

Rated by Lovi · Unbiased, science-based skincare AI trained on real user outcomes

Medik8 Oxy-R Peptides

High

  • HighNormal Skin Fit
  • HighEffectiveness
  • HighSafety

A great choice for sensitive skin; a few serums fit it even better.

This fit is calculated for the concerns frequently associated with sensitive skin: redness, stinging, and reactions to new products. For scores and recommendations based on your full skin profile, including your 12D face scan results and any goals or preferences you have, please use the Lovi app.

Page built Nov 8, 2026How the Fit score works

Lovi Assistant explains

  • Highly suitable for your normal skin, this product effectively addresses redness and irritation with Hydroxyresveratrol and Tetrapeptide-30, which offer soothing and anti-inflammatory effects. Glycerin and Sodium Hyaluronate further enhance hydration, complementing your skin type.
  • The formulation also provides excellent skin brightening by evening your skin tone through the synergistic action of Hydroxyresveratrol and Tetrapeptide-30.
  • The safety profile is excellent, with no risks of irritation for your sensitive skin due to the absence of prohibited or harsh ingredients.

How to apply

  • Use your serum in the PM routine, starting 3 times a week before building up to daily use if your skin is happy.
  • Apply the serum after cleansing and toning, but before putting on your moisturizer for the best results.
  • Gently press 2-3 drops of the serum into your skin and wait a minute ⏱ for it to soak in.
  • Since your skin is sensitive and easily irritated, apply the serum on completely dry skin to help keep it calm.
  • Always do a patch test before your first use and avoid getting the serum too close to your eyes .

People Say

★4.4Overall rating based on 1.1k+ reviews

Based on a very large amount of data, users with hyperpigmentation, melasma, and post-inflammatory erythema (PIE) frequently report visible skin brightening and the fading of dark spots, often noting a smoother texture and "glass-like" glow within weeks. While many experience rapid results, a minority of users report no visible changes or mild breakouts, and the short shelf life of the activated formula is a noted consideration.

Highlights

  • Fades dark spots Often Mentioned
    • “pigmentation lightened slightly”
    • “fading uneven skin tone”
    • “dark spots visibly reduced”
    • “helped post-acne marks”
  • Improves skin texture Often Mentioned
    • “skin feels firmer”
    • “looks more awake”
    • “smoother texture”
    • “glass-like glow”
    • “healthier overall”
  • Fast absorption Sometimes Noted
    • “absorbs fast”
    • “soaks into skin easily”
    • “non-greasy”
    • “layers well”
    • “lightweight silky serum”
  • Gentle formulation Sometimes Noted
    • “no irritation at all”
    • “gentle to use”
    • “suitable for sensitive skin”
    • “didn't dry me out”
  • Rapid results Sometimes Noted
    • “results in 7 days”
    • “brighter and clearer quickly”
    • “works fast”
    • “noticeable difference in weeks”
  • Ineffective for some Sometimes Noted
    • “no difference”
    • “haven't noticed changes”
    • “not impressed”
    • “melasma didn't budge”
  • Caused breakouts Rarely Noted
    • “caused breakouts”
    • “mild reaction”
    • “bumps appeared”
    • “skin purging”
  • Packaging issues Rarely Noted
    • “click mechanism tricky”
    • “hard to activate”
    • “dropper issues”
  • Short shelf life Rarely Noted
    • “use within 6 weeks”
    • “runs out quickly”
    • “two small bottles”
    • “oxidizes if not used fast”

Sources: lovi.care, medik8.com, spacenk.com, lookfantastic.com, cultbeauty.co.uk, dermstore.com, and more

Questions and answers

What makes Medik8 Oxy-R Peptides a great fit for sensitive skin?

Medik8 Oxy-R Peptides is a great fit for sensitive skin because it uses Hydroxyresveratrol and Tetrapeptide-30 to soothe redness and irritation while evening your skin tone. Glycerin and Sodium Hyaluronate also help keep your skin hydrated, and the formula is very safe with no harsh ingredients to trigger your skin.

Journal of Cosmetic Dermatology, 2017

Which ingredients make this serum a good fit for sensitive skin?

Hydroxyresveratrol and Tetrapeptide-30 make this serum a great fit because they help soothe redness and calm irritation on sensitive skin. Glycerin and Sodium Hyaluronate further support this fit by drawing in hydration to keep your skin feeling soft and comfortable.

What does Oxyresveratrol do for sensitive skin?

Oxyresveratrol helps calm irritated skin and protects cells from sun damage through its antioxidant activity. A product for sensitive skin of this type needs soothing plant extracts and gentle anti-inflammatory ingredients to keep skin calm and comfortable.

Heliyon, 2024

What do Peptides do for sensitive skin?

Peptides help support the skin barrier and improve the feel of sensitive skin by encouraging firmness and a smooth look. When paired with soothing and hydrating ingredients, peptide products are generally well tolerated and unlikely to cause irritation.

Advanced Science, 2025Journal of Biomedical Materials Research, 1998

Where does this serum go in a skincare routine for sensitive skin?

This treatment goes in your evening routine, applied after your toner and before your moisturizer. It is a great fit for sensitive skin because it uses soothing ingredients to calm redness without harsh risks.

Can I use this serum with retinol, and in what order?

You can use this treatment alongside a retinol by applying your soothing toner first, then this serum, followed by your moisturizer and retinol carefully to avoid irritation. Because this formula contains gentle soothing ingredients like Hydroxyresveratrol and hydrating Glycerin, it is unlikely to cause discomfort when paired with other actives.

Clinical, Cosmetic and Investigational Dermatology, 2017

How often should I use it?

You can use this treatment in your evening routine, starting once a week and gradually using it more often if your sensitive skin tolerates it well. Its soothing ingredients and gentle formula help calm redness and irritation while keeping your skin comfortable.

Can this serum clog pores, cause breakouts or purging for sensitive skin?

This serum is unlikely to clog pores or cause breakouts on sensitive skin due to its very safe formula and absence of harsh ingredients. Reviewers rarely report breakouts, and soothing ingredients help keep redness and irritation at bay.

Is it fragrance-free and alcohol-free?

Yes, it has no fragrance and no drying alcohol.

What the research says

  • A single application of a moisturizing fluid containing hyaluronic acid 1%, glycerin 5%, and Centella asiatica stem cells extract significantly increased skin hydration by 29% and reduced transepidermal water loss at 24 hours compared to baseline and an untreated control site in twenty healthy women.

    Clinical, Cosmetic and Investigational Dermatology, 2017

  • Application of a new brightening complex cream containing niacinamide, tranexamic acid, oxyresveratrol, glutathione disulfide, and linoleic acid for 12 weeks increased skin lightness (L*-value) and significantly decreased melanin index and erythema index in Korean women.

    Journal of Cosmetic Dermatology, 2017

  • Topical application of mulberroside A, oxyresveratrol, and oxyresveratrol-3-O-glucoside reduced UVB-induced skin pigmentation and melanogenic enzyme expression in brown guinea pigs compared to vehicle control, with oxyresveratrol showing the greatest effect.

    Food and Chemical Toxicology, 2011

  • Topical oxyresveratrol microemulsion at 20-30% w/w effectively delayed skin lesion development and protected mice from death compared to untreated controls.

    AAPS PharmSciTech, 2012

  • Encapsulating dihydrooxyresveratrol and oxyresveratrol into nanostructured lipid carriers enhanced photostability, promoted controlled release, facilitated skin penetration, exhibited no cytotoxicity up to 500 µg/mL on human keratinocytes, and effectively reduced melanogenesis in B16F10 cells.

    Scientific Reports, 2024

  • Oxyresveratrol alleviates ultraviolet B-induced cytotoxicity and inflammation in keratinocytes by exhibiting antioxidant activity, inhibiting p38 MAPK and AP-1, and decreasing the Bax/Bcl-2 ratio.

    Heliyon, 2024

  • Topical application of 0.1% hyaluronic acid formulations of different molecular weights led to significant improvements in skin hydration and elasticity, with low-molecular-weight formulations also significantly reducing wrinkle depth in seventy-six female subjects compared to a vehicle control.

    Journal of Drugs in Dermatology, 2011

  • Topical application of hyaluronic acid in conjunction with free gingival graft significantly reduced donor site postoperative pain until day 7 compared to normal saline, with no significant differences in graft dimensions or patient satisfaction.

    Clinical Oral Investigations, 2022

  • Treatment with a hyaluronic acid-containing mouth rinse or topical gel led to significant lesion reduction, pain relief, and normalization of lesion color in adult patients with minor recurrent aphthous stomatitis, with the gel formulation showing an earlier healing onset at 3 days.

    BMC Oral Health, 2019

  • Application of a cream containing lactic acid 12% and pramoxine HCl 1% significantly improved skin dryness, hydration, and itch compared with a nontreated control in 24 women with a history of dry itchy skin.

    Cutis, 2004

  • Topical 12% ammonium lactate produced a significant sparing of epidermal and dermal atrophy induced by clobetasol propionate in human volunteers, without influencing the corticosteroid's bioavailability or antiinflammatory properties.

    Journal of the American Academy of Dermatology, 1992

  • A lactic acid/ceramide lotion significantly improved skin moisturization and desquamation compared to no treatment in women with dry, rough skin on the anterior shins.

    The Journal of Clinical and Aesthetic Dermatology, 2020

  • The emollient V0034CR significantly reduced TEWL compared to vehicle and vehicle plus glycerol, and significantly increased corneometry scores compared to vehicle and vehicle plus petrolatum in healthy volunteers with dry skin, demonstrating combined barrier function improvement from petrolatum and hydration improvement from glycerol.

    Journal of Cosmetic Dermatology, 2020

  • Ten days of treatment with a cream containing 20% glycerin significantly increased skin hydration measured by corneometer values in 17 healthy volunteers compared to a placebo cream, but showed no influence on transepidermal water loss or skin sensitivity to an irritating surfactant.

    International Journal of Cosmetic Science, 2001

  • Niacinamide/glycerin body moisturizers provided better rapid and prolonged improvement of cosmetic xerosis through functional improvement of stratum corneum barrier function compared to no treatment and conventional moisturizers in female subjects.

    Journal of Drugs in Dermatology, 2012

Ingredients

Water, Butylene Glycol, Artocarpus Lakoocha Extract Wood, Hydroxyresveratrol, Gluconolactone, Acetyl Glycyl Beta-Alanine, Glycerin, Lactic Acid, Sodium Hyaluronate, Sodium Benzoate, Disodium Edta, Tetrapeptide-30, Xanthan Gum, Sodium Metabisulfite, Calcium Gluconate

Behind this fit score

Lovi calculates every fit score from the full ingredient list with brand-independent rules our dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update.

  • Nadia Kapleva, MS

    Nadia Kapleva, MS

    Co-founder, Medical Director

    Cosmetic chemist, cosmetologist, aesthetic products developer

  • Alexey Shagraev, PhD

    Alexey Shagraev, PhD

    Co-founder, CEO and CTO

    PhD in computer science, 3x US patent holder, ex-Google, ex-Yandex

  • Dr. Sofía Perea Pérez, MD, MSc

    Dr. Sofía Perea Pérez, MD, MSc

    Medical Board

    Aesthetic medicine practitioner, MSc in Longevity and Anti-Aging Medicine

  • Aishani Shah, MD

    Aishani Shah, MD

    Medical Board

    Specialist dermatologist, MBBS, MD, IFAAD

  • Asya Zubkova, MS

    Asya Zubkova, MS

    Medical Board

    Cosmetic chemist, SCS, IFSCC member

  • Hanna Kurets, MD

    Hanna Kurets, MD

    Medical Board, Medical Advisor

    Dermatology MD

  • Elina Nazarenko, MD

    Elina Nazarenko, MD

    Medical Board

    Dermatology and diagnostic consultant

  • Victoria Derkova, MS

    Victoria Derkova, MS

    Medical Board

    Cosmetic chemist, cosmetic development technologist

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How does it fit your skin?

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QR code: get the Lovi app
Download on theApp Store Get it onGoogle Play