Topical use of dexpanthenol in skin disorders
Panthenol · American Journal of Clinical Dermatology, 2002Improvement of naturally aged skin with vitamin A (retinol)
Retinol · Archives of Dermatology, 2007Topical ascorbic acid on photoaged skin. Clinical, topographical and ultrastructural evaluation: double-blind study vs. placebo
Ascorbic acid activ cg · Experimental Dermatology, 2003Anti-aging and brightening effects of a topical treatment containing vitamin C, vitamin E, and raspberry leaf cell culture extract: A split-face, randomized controlled trial
Tocopherol vitamin e, Tocopherol, Ascorbic acid · Journal of Cosmetic Dermatology, 2020A topical antioxidant solution containing vitamins C and E stabilized by ferulic acid provides protection for human skin against damage caused by ultraviolet irradiation
Ferulic acid · Journal of the American Academy of Dermatology, 2008Protective effects of a topical antioxidant mixture containing vitamin C, ferulic acid, and phloretin against ultraviolet-induced photodamage in human skin
Ferulic acid · Journal of Cosmetic Dermatology, 2008Molecular basis of retinol anti-ageing properties in naturally aged human skin in vivo
Retinol · International Journal of Cosmetic Science, 2017Production and characterization of cosmetic nanoemulsions containing Opuntia ficus-indica (L.) mill extract as moisturizing agent
Hydrolyzed opuntia ficus-indica flower extract · Molecules, 2015Topical anti-inflammatory effects of isorhamnetin glycosides isolated from Opuntia ficus-indica
Hydrolyzed opuntia ficus-indica flower extract · BioMed Research International, 2015Prospective, randomized, double-blind assessment of topical bakuchiol and retinol for facial photoageing
Bakuchiol · The British Journal of Dermatology, 2019Topical delivery of tetrahydrocurcumin lipid nanoparticles effectively inhibits skin inflammation: in vitro and in vivo study
Tetrahydrodiferuloylmethane · Drug Development and Industrial Pharmacy, 2018Vitamin C-squalene bioconjugate promotes epidermal thickening and collagen production in human skin
Squalane · Scientific Reports, 2020Treatment of acne with a combination of propolis, tea tree oil, and Aloe vera compared to erythromycin cream: two double-blind investigations
Aloe barbadensis leaf juice · Clinical Pharmacology, 2018Urea: a comprehensive review of the clinical literature
Urea · Dermatology Online Journal, 2013Effects of glyceryl glucoside on AQP3 expression, barrier function and hydration of human skin
Glyceryl glucoside · Skin Pharmacology and Physiology, 2012Antioxidant Opuntia ficus-indica Extract Activates AHR-NRF2 Signaling and Upregulates Filaggrin and Loricrin Expression in Human Keratinocytes
Hydrolyzed opuntia ficus-indica flower extract · Journal of Medicinal Food, 2015Effect of a topical antioxidant serum containing vitamin C, vitamin E, and ferulic acid after Q-switched 1064-nm Nd:YAG laser for treatment of environment-induced skin pigmentation
Tocopherol vitamin e, Ferulic acid · Journal of Cosmetic Dermatology, 2020Inhibitory effect of mulberroside A and its derivatives on melanogenesis induced by ultraviolet B irradiation
Hydroxyresveratrol · Food and Chemical Toxicology, 2011Clinical, biometric and structural evaluation of the long-term effects of a topical treatment with ascorbic acid and madecassoside in photoaged human skin
Centella asiatica leaf extract · Experimental Dermatology, 2008The 24-hour skin hydration and barrier function effects of a hyaluronic 1%, glycerin 5%, and Centella asiatica stem cells extract moisturizing fluid: an intra-subject, randomized, assessor-blinded study
Glycerin · Clinical, Cosmetic and Investigational Dermatology, 2017Randomized controlled study for the anti-aging effect of human adipocyte-derived mesenchymal stem cell media combined with niacinamide after laser therapy
Niacinamide · Journal of Cosmetic Dermatology, 2021The anti-wrinkle efficacy of argireline, a synthetic hexapeptide, in Chinese subjects: a randomized, placebo-controlled study
Acetyl hexapeptide-8 · American Journal of Clinical Dermatology, 2013Senomorphic activity of a combination of niacinamide and hyaluronic acid: correlation with clinical improvement of skin aging
Niacinamide · Scientific Reports, 2024A new topical panthenol-containing emollient: Results from two randomized controlled studies assessing its skin moisturization and barrier restoration potential, and the effect on skin microflora
Panthenol · The Journal of Dermatological Treatment, 2017A Double-Blinded, Randomized, Vehicle-Controlled Study of the Efficacy of Moisturizer Containing Licochalcone A, Decanediol, L-Carnitine, and Salicylic Acid for Prevention of Acne Relapse in Asian Population
Salicylic acid · BioMed Research International, 2020Efficacy and tolerability assessment of a topical formulation containing copper sulfate and hypericum perforatum on patients with herpes skin lesions: a comparative, randomized controlled trial
Copper sulfate · Journal of Drugs in Dermatology, 2012Adenosine-loaded dissolving microneedle patches to improve skin wrinkles, dermal density, elasticity and hydration
Adenosine · International Journal of Cosmetic Science, 2018Treatment of xerosis with a topical formulation containing glyceryl glucoside, natural moisturizing factors, and ceramide
Moisturizing factors nmf, Glyceryl glucoside · The Journal of Clinical and Aesthetic Dermatology, 2012Comparative study of efficacy and safety of 45% mandelic acid versus 30% salicylic acid peels in mild-to-moderate acne vulgaris
Mandelic acid · Journal of Cosmetic Dermatology, 2020Sunscreens and Cosmetic Formulations Containing Ascorbyl Tetraisopalmitate and Rice Peptides for the Improvement of Skin Photoaging: A Double-blind, Randomized Placebo-controlled Clinical Study
Tetrahexyldecyl ascorbate · Photochemistry and Photobiology, 2021Clinical evidence of the efficacy and safety of a new 3-in-1 anti-aging topical night serum-in-oil containing melatonin, bakuchiol, and ascorbyl tetraisopalmitate: 103 females treated from 28 to 84 days
Tetrahexyldecyl ascorbate · Journal of Cosmetic Dermatology, 2019The efficacy of glycolic acid, salicylic acid, gluconolactone, and licochalcone A combined with 0.1% adapalene vs adapalene monotherapy in mild-to-moderate acne vulgaris: a double-blinded within-person comparative study
Gluconolactone, Glycolic acid · Clinical, Cosmetic and Investigational Dermatology, 2019Efficacy of a topical gel containing chitosan, chlorhexidine, allantoin and dexpanthenol for pain and inflammation control after third molar surgery: A randomized and placebo-controlled clinical trial
Allantoin, Panthenol · Medicina Oral, Patologia Oral Y Cirugia Bucal, 2020Anti-Wrinkle Efficacy of Cross-Linked Hyaluronic Acid-Based Microneedle Patch with Acetyl Hexapeptide-8 and Epidermal Growth Factor on Korean Skin
Acetyl hexapeptide-8 · Annals of Dermatology, 2019Systematic Study of Paeonol/Madecassoside Co-Delivery Nanoemulsion Transdermal Delivery System for Enhancing Barrier Repair and Anti-Inflammatory Efficacy
Centella asiatica leaf extract · Molecules, 2023A comparative study of gluconolactone versus benzoyl peroxide in the treatment of acne
Gluconolactone · The Australasian Journal of Dermatology, 1992Biomimetic hyaluronic acid-stabilized zinc oxide nanoparticles in acne treatment: A preclinical and clinical approach
Zinc oxide · Journal of Controlled Release, 2025An oil-soluble extract of Rubus idaeus cells enhances hydration and water homeostasis in skin cells
Rubus idaeus fruit extract raspberry fruit extract · International Journal of Cosmetic Science, 2015Fatty acids based α-Tocopherol loaded nanostructured lipid carrier gel: In vitro and in vivo evaluation for moisturizing and anti-aging effects
Vitamin e · Journal of Cosmetic Dermatology, 2020Efficacy of a multitargeted, salicylic acid-based dermocosmetic cream compared to benzoyl peroxide 5% in Acne vulgaris: Results from a randomized study
Salicylic acid · Journal of Cosmetic Dermatology, 2024A dermocosmetic containing bakuchiol, Ginkgo biloba extract and mannitol improves the efficacy of adapalene in patients with acne vulgaris: result from a controlled randomized trial
Bakuchiol · Clinical, Cosmetic and Investigational Dermatology, 2015Efficacy of a topical serum containing L-ascorbic acid, neohesperidin, pycnogenol, tocopherol, and hyaluronic acid in relation to skin aging signs
Vitamin e · Journal of Cosmetic Dermatology, 2022Antioxidant-based topical formulations influence on the inflammatory response of Japanese skin: A clinical study using non-invasive techniques
Tetrahexyldecyl ascorbate · European Journal of Pharmaceutics and Biopharmaceutics, 2017Efficacy and safety of moisturizer containing 5% panthenol, madecassoside, and copper-zinc-manganese versus 0.02% triamcinolone acetonide cream in decreasing adverse reaction and downtime after ablative fractional carbon dioxide laser resurfacing: A split-face, double-blinded, randomized, controlled trial
Centella asiatica leaf extract · Journal of Cosmetic Dermatology, 2019Retaining Skin Barrier Function Properties of the Stratum Corneum with Components of the Natural Moisturizing Factor-A Randomized, Placebo-Controlled Double-Blind In Vivo Study
Moisturizing factors nmf · Molecules, 2021A Salicylic Acid-Based Dermocosmetic is Effective as an Adjunct to Benzoyl Peroxide for Mild to Moderate Acne and as Monotherapy in Maintenance Post Benzoyl Peroxide
Salicylic acid · Journal of Drugs in Dermatology, 2023Assessment of the Benefit of a Deep Cleansing Gel Containing Salicylic Acid 2%, Zinc Gluconate 0.2% and Lipohydroxy Acids 0.05% in Patients with Mild to Moderate Truncal Acne: Results from an Exploratory Study
Zinc gluconate · Clinical, Cosmetic and Investigational Dermatology, 2023A new dermocosmetic containing retinaldehyde, delta-tocopherol glucoside and glycylglycine oleamide for managing naturally aged skin: results from in vitro to clinical studies
Tocopheryl glucoside · Clinical, Cosmetic and Investigational Dermatology, 2017Efficacy and safety of non-thermal nitrogen plasma versus long-pulsed Nd:YAG laser for hand rejuvenation
Nitrogen · Lasers in Medical Science, 2022Development of stable tocopherol succinate-loaded ethosomes to enhance transdermal permeation: In vitro and in vivo characterizations
Vitamin e · Journal of Cosmetic Dermatology, 2022Topical application of jojoba (Simmondsia chinensis L.) wax enhances the synthesis of pro-collagen III and hyaluronic acid and reduces inflammation in the ex-vivo human skin organ culture model
Jojoba seed oil · Frontiers in Pharmacology, 2024Clinical evaluation of the efficacy of a facial serum containing dioic acid, glycolic acid, salicylic acid, LHA, citric acid, and HEPES in treating post-inflammatory hyperchromia and controlling oily skin in patients with acne vulgaris
Citric acid · Journal of Cosmetic Dermatology, 2021Evaluation of moisturizing and irritation potential of sacha inchi oil
Plukenetia volubilis seed oil · Journal of Cosmetic Dermatology, 2020Comparative benefit of two thermal spring waters after photodynamic therapy procedure
Avène thermal spring water, Avene thermal spring water avene aqua · Journal of Cosmetic Dermatology, 2007A randomized, double-blind, vehicle-controlled study of a preparation containing undecylenoyl phenylalanine 2% in the treatment of solar lentigines
Undecylenoyl phenylalanine · Clinical and Experimental Dermatology, 2010Wax-oil lubricants to reduce the shear between skin and PPE
Paraffinum liquidum mineral oil · Scientific Reports, 2021Two-phase delivery using a horse oil and adenosine-loaded dissolving microneedle patch for skin barrier restoration, moisturization, and wrinkle improvement
Adenosine · Journal of Cosmetic Dermatology, 2019Development of solid lipid microparticles (SLMs) containing asiatic acid for topical treatment of acne: Characterization, stability, in vitro and in vivo anti-acne assessment
Centella asiatica leaf extract · International Journal of Pharmaceutics, 2024Synergetic Effects of Aloe Vera Extract with Trimethylglycine for Targeted Aquaporin 3 Regulation and Long-Term Skin Hydration
Aloe barbadensis flower extract · Molecules, 2024Squalane as a Promising Agent Protecting UV-Induced Inhibition of Collagen Biosynthesis and Wound Healing in Human Dermal Fibroblast
Squalane · Molecules, 2025Clinical Development and Evaluation of a Multi-Component Dissolving Microneedle Patch for Skin Pigmentation Disorders
3-o-ethyl ascorbic acid · Polymers, 2023Fractional microneedle radiofrequency with the application of vitamin C, E, and ferulic acid serum for neck skin rejuvenation: a prospective, double-blinded, split-neck, placebo-controlled trial
Ferulic acid · The Journal of Dermatological Treatment, 2025Comparison of methods for assessing photoprotection against ultraviolet A in vivo
Butyl methoxydibenzoylmethane · Journal of the American Academy of Dermatology, 1987Using ordered mesoporous silica SBA-15 to limit cutaneous penetration and transdermal permeation of organic UV filters
Butyl methoxydibenzoylmethane · International Journal of Pharmaceutics, 2019Depth-dependent hydration dynamics in human skin: Vehicle-controlled efficacy assessment of a functional 10% urea plus NMF moisturizer by near-infrared confocal spectroscopic imaging (KOSIM IR) and capacitance method complemented by volunteer perception
Moisturizing factors nmf · Skin Research and Technology, 2022Effect of hydroxypropyl-β-cyclodextrin in fluid and semi-solid submicron emulsions on physiological skin parameters during regular in vivo application
Cyclodextrin · International Journal of Cosmetic Science, 2021Topical Zinc Oxide Nanoparticle Formulations for Acne Vulgaris: A Systematic Review of Pre-Clinical and Early-Phase Clinical Evidence
Zinc oxide · Biomedicines, 2025Influence of vitamin E acetate on stratum corneum hydration
Tocopheryl acetate · Arzneimittel-Forschung, 1998Emulgels Containing Perilla frutescens Seed Oil, Moringa oleifera Seed Oil, and Mixed Seed Oil: Microemulsion and Safety Assessment
Moringa oleifera seed oil · Polymers, 2022Assessment of the efficacy and safety of a new complex skin cream in Asian women: A controlled clinical trial
Hydroxyresveratrol · Journal of Cosmetic Dermatology, 2017A randomized controlled trial to compare the effectiveness and safety of adsorbent lotion containing tapioca starch, spent grain wax, Butyrospermum parkii extract, argania spinosa kernel oil, aloe barbadensis, rosehip oil, and allantoin with a low-potency topical corticosteroid in the treatment of intertrigo
Shea butter · Journal of Cosmetic Dermatology, 2022Lactobionic acid in a natural alkylpolyglucoside-based vehicle: assessing safety and efficacy aspects in comparison to glycolic acid
Pha polyhydroxy acid · Journal of Cosmetic Dermatology, 2010Specific protection of sensitive skin against environmental stress by maintenance and improvement of barrier function
Aquaphilus dolomiae extract filtrate · Journal of the European Academy of Dermatology and Venereology, 2022TiO2-embedded mesoporous silica with lower porosity is beneficial to adsorb the pollutants and retard UV filter absorption: A possible application for outdoor skin protection
Butyl methoxydibenzoylmethane · European Journal of Pharmaceutical Sciences, 2023The anti wrinkle efficacy of synthetic hexapeptide (Argireline) in Chinese Subjects
Acetyl hexapeptide-8 · Journal of Cosmetic and Laser Therapy, 2013Tocopherol succinate-loaded ethosomal gel synthesized by cold method technique: Deeper biophysical characterizations for translational application on human skin
Vitamin e · Journal of Cosmetic Dermatology, 2024Evaluation of the Efficacy and Safety of a Panthenol-Enriched Mask for Skin Barrier Recovery After Facial Laser Treatment: Results of a Double-Blind Randomized Controlled Study
Panthenol · Journal of Cosmetic Dermatology, 2025Effect of an Emollient Emulsion Containing 15.0% of Caprylic/Capric Triglyceride on the Urocanic Acid of the Stratum Corneum
Caprylic capric triglyceride · Life, 2023Sustained effect of two antioxidants (oxothiazolidine and δ-tocopheryl glucoside) for immediate and long-term sun protection in a sunscreen emulsion based on their different penetrating properties
Tocopheryl glucoside · International Journal of Cosmetic Science, 2021Comparison of clindamycin 1% and benzoyl peroxide 5% gel to a novel composition containing salicylic acid, capryloyl salicylic acid, HEPES, glycolic acid, citric acid, and dioic acid in the treatment of acne vulgaris
Citric acid · Journal of Drugs in Dermatology, 2013Nanostructured Lipid Carrier Based Gel Containing α-Tocopherol and α-Tocopheryl Acetate for Synergistic Cutaneous Antiaging Efficacy
Tocopheryl acetate · Scientific Reports, 2025Clinical evaluation of anaesthetic-like effect of two dermocosmetic formulations containing Aquaphilus dolomiae extract-G3 in subjects with sensitive facial skin
Aquaphilus dolomiae extract filtrate · Journal of the European Academy of Dermatology and Venereology, 2022The Real-World Effectiveness and Tolerability of a Soothing Cream Containing the Postbiotic Aquaphilus dolomiae Extract-G2 for Skin Healing
Aquaphilus dolomiae extract filtrate · Dermatology and Therapy, 2024A Double-Blind, 12-Week Study to Evaluate the Antiaging Efficacy of a Cream Containing the NFκB Inhibitor 4-Hexyl-1, 3-Phenylenediol and Ascorbic Acid-2 Glucoside in Adult Females
Ascorbyl glucoside · Journal of Drugs in Dermatology, 2016Protective properties of Avène Thermal Spring Water on biomechanical, ultrastructural and clinical parameters of human skin
Thermal spring water, Aqua dolomiae extract · Journal of the European Academy of Dermatology and Venereology, 2020Prospective randomized double-blind comparative study of topical acetyl zingerone with tetrahexyldecyl ascorbate versus tetrahexyldecyl ascorbate alone on facial photoaging
Tetrahexyldecyl ascorbate · Journal of Cosmetic Dermatology, 2024Effects of Malaysian thermal spring water as adjunct therapy for mild to moderate acne vulgaris - a prospective, randomised, controlled, split face study
Avène thermal spring water, Avene thermal spring water avene aqua, Thermal spring water · The Medical Journal of Malaysia, 2024Rapid and Visible Efficacy of a Dermocosmetic in Acne Patients With Fair Skin Phototypes: Results of a Randomized Split-Face Study
Zinc gluconate · Journal of Cosmetic Dermatology, 2026Safety assessment on comedogenicity of dermatological products containing d-alpha tocopheryl acetate in Asian subjects: A double-blind randomized controlled trial
Tocopheryl acetate, Tocopheryl acetate vitamin e · Contemporary Clinical Trials Communications, 2021A cleanser formulated with Tris (hydroxymethyl) aminomethane and l-arginine significantly improves facial acne in male Thai subjects
Arginine · Journal of Cosmetic Dermatology, 2020Treatment with Ascorbyl Glucoside-Arginine Complex Ameliorates Solar Lentigos
Ascorbyl glucoside · International Journal of Molecular Sciences, 2024A Randomized Controlled Trial of the Genistein Plus Bakuchiol and Vitamins (GEN+) Product for Male Facial Skin: Effects on Skin Appearance and Properties
Bakuchiol · Skin Research and Technology, 2026A polyhydroxy acid skin care regimen provides antiaging effects comparable to an alpha-hydroxyacid regimen
Pha polyhydroxy acid · Cutis, 2004Retrospective Review of Dermal Safety Studies of Organic Sunscreens
Ethylhexyl salicylate · Journal of Drugs in Dermatology, 2025Efficacy and safety of combination cream of stimu-tex AS™ (spent grain wax, Argania Spinosa Kernel oil, Butyrospermum Parkii (shea butter) extract), and saccharide isomerate after fractional CO2 laser procedure: split-face, double blinded, randomized controlled trial
Shea butter · Lasers in Medical Science, 2025Clinical Evaluation of a Soap-Free Cleansing Lotion Containing Sodium Cocoyl Apple Amino Acids for Effective Impurity Removal and Skin Barrier Preservation in Healthy Adults With Diverse Skin Types
Cetyl alcohol · Cureus, 2025Dermatological Effects of a Beeswax-Pine Resin Mixture on Abdominal Skin: A Proof-of-Concept Study Supporting the Development of an Affordable Investigational Ostomy Pouching System in Low-Income Regions
Beeswax cera alba cera · Journal of Wound, Ostomy, and Continence Nursing, 2026Prospective, Randomized, Double-Blind Assessment of Supramolecular Bakuchiol and Terminalia Chebula Extract for Facial Photoaging in Chinese Sensitive Skin Population
Bakuchiol · Health Science Reports, 2025Targeting Circadian Rhythm for the Regulation of Skin Collagen Metabolism
Palmitoyl tripeptide-1 · Journal of Cosmetic Dermatology, 2026Split-face evaluation: Gluconolactone plus oxybrasion versus gluconolactone plus microneedling. The effects on skin parameters
Gluconolactone · Skin Research and Technology, 2023Preclinical Safety Evaluation of Dual Drug-Loaded Nanolipidic Carriers of Dissolvable Patches: In-Vitro and In-Vivo Safety Assessment
Tetrahydrodiferuloylmethane · Molecular Pharmaceutics, 2025Acai Oil-Based Organogel Containing Hyaluronic Acid for Topical Cosmetic: In Vitro and Ex Vivo Assessment
Euterpe oleracea fruit extract · Pharmaceutics, 2024