Benefits of topical hyaluronic acid for skin quality and signs of skin aging: From literature review to clinical evidence
Hyaluronic acid, Sodium hyaluronate · Dermatologic Therapy, 2022Topical use of dexpanthenol in skin disorders
Panthenol · American Journal of Clinical Dermatology, 2002Cutaneous photoprotection from ultraviolet injury by green tea polyphenols
Camellia sinensis extract · Journal of the American Academy of Dermatology, 2001Epigallocatechin-3-gallate improves acne in humans by modulating intracellular molecular targets and inhibiting P. acnes
Camellia sinensis · The Journal of Investigative Dermatology, 2013Regulatory effects of Lactobacillus plantarum-GMNL6 on human skin health by improving skin microbiome
Probiotics · International Journal of Medical Sciences, 2021Anti-aging and brightening effects of a topical treatment containing vitamin C, vitamin E, and raspberry leaf cell culture extract: A split-face, randomized controlled trial
Tocopherol vitamin e, Tocopherol, Ascorbic acid · Journal of Cosmetic Dermatology, 2020A topical antioxidant solution containing vitamins C and E stabilized by ferulic acid provides protection for human skin against damage caused by ultraviolet irradiation
Ferulic acid · Journal of the American Academy of Dermatology, 2008Protective effects of a topical antioxidant mixture containing vitamin C, ferulic acid, and phloretin against ultraviolet-induced photodamage in human skin
Ferulic acid · Journal of Cosmetic Dermatology, 2008Anti-microbial and -inflammatory activity and efficacy of phytosphingosine: an in vitro and in vivo study addressing acne vulgaris
Phytosphingosine · International Journal of Cosmetic Science, 2007Production and characterization of cosmetic nanoemulsions containing Opuntia ficus-indica (L.) mill extract as moisturizing agent
Hydrolyzed opuntia ficus-indica flower extract · Molecules, 2015Topical anti-inflammatory effects of isorhamnetin glycosides isolated from Opuntia ficus-indica
Hydrolyzed opuntia ficus-indica flower extract · BioMed Research International, 2015Prospective, randomized, double-blind assessment of topical bakuchiol and retinol for facial photoageing
Bakuchiol · The British Journal of Dermatology, 2019Moisturizing and Antiinflammatory Properties of Cosmetic Formulations Containing Centella asiatica Extract
Centella asiatica extract · Indian Journal of Pharmaceutical Sciences, 2016Topical delivery of tetrahydrocurcumin lipid nanoparticles effectively inhibits skin inflammation: in vitro and in vivo study
Tetrahydrodiferuloylmethane · Drug Development and Industrial Pharmacy, 2018Topical Application of Centella asiatica in Wound Healing: Recent Insights into Mechanisms and Clinical Efficacy
Centella asiatica extract · Pharmaceutics, 2024Vitamin C-squalene bioconjugate promotes epidermal thickening and collagen production in human skin
Squalane · Scientific Reports, 2020Treatment of acne with a combination of propolis, tea tree oil, and Aloe vera compared to erythromycin cream: two double-blind investigations
Aloe barbadensis leaf juice · Clinical Pharmacology, 2018Urea: a comprehensive review of the clinical literature
Urea · Dermatology Online Journal, 2013Alteration of barrier properties, stratum corneum ceramides and microbiome composition in response to lotion application on cosmetic dry skin
Sphingolipids · Scientific Reports, 2022Effects of glyceryl glucoside on AQP3 expression, barrier function and hydration of human skin
Glyceryl glucoside · Skin Pharmacology and Physiology, 2012Antioxidant Opuntia ficus-indica Extract Activates AHR-NRF2 Signaling and Upregulates Filaggrin and Loricrin Expression in Human Keratinocytes
Hydrolyzed opuntia ficus-indica flower extract · Journal of Medicinal Food, 2015Ceramide 1 and ceramide 3 act synergistically on skin hydration and the transepidermal water loss of sodium lauryl sulfate-irritated skin
Ceramide np · International Journal of Dermatology, 2008Effect of a topical antioxidant serum containing vitamin C, vitamin E, and ferulic acid after Q-switched 1064-nm Nd:YAG laser for treatment of environment-induced skin pigmentation
Tocopherol vitamin e, Ferulic acid · Journal of Cosmetic Dermatology, 2020Injectable thermo-sensitive and wide-crack self-healing hydrogel loaded with antibacterial anti-inflammatory dipotassium glycyrrhizate for full-thickness skin wound repair
Dipotassium glycyrrhizate · Acta Biomaterialia, 2022Inhibitory effect of mulberroside A and its derivatives on melanogenesis induced by ultraviolet B irradiation
Hydroxyresveratrol · Food and Chemical Toxicology, 2011Green tea extract reduces induction of p53 and apoptosis in UVB-irradiated human skin independent of transcriptional controls
Camellia sinensis leaf extract · Experimental Dermatology, 2009Clinical, biometric and structural evaluation of the long-term effects of a topical treatment with ascorbic acid and madecassoside in photoaged human skin
Centella asiatica leaf extract · Experimental Dermatology, 2008The 24-hour skin hydration and barrier function effects of a hyaluronic 1%, glycerin 5%, and Centella asiatica stem cells extract moisturizing fluid: an intra-subject, randomized, assessor-blinded study
Glycerin · Clinical, Cosmetic and Investigational Dermatology, 2017Randomized controlled study for the anti-aging effect of human adipocyte-derived mesenchymal stem cell media combined with niacinamide after laser therapy
Niacinamide · Journal of Cosmetic Dermatology, 2021Cytotoxicity of lecithin-based nanoemulsions on human skin cells and ex vivo skin permeation: Comparison to conventional surfactant types
Hydrogenated lecithin · International Journal of Pharmaceutics, 2019The anti-wrinkle efficacy of argireline, a synthetic hexapeptide, in Chinese subjects: a randomized, placebo-controlled study
Acetyl hexapeptide-8 · American Journal of Clinical Dermatology, 2013A new topical panthenol-containing emollient: Results from two randomized controlled studies assessing its skin moisturization and barrier restoration potential, and the effect on skin microflora
Panthenol · The Journal of Dermatological Treatment, 2017Senomorphic activity of a combination of niacinamide and hyaluronic acid: correlation with clinical improvement of skin aging
Niacinamide · Scientific Reports, 2024A Double-Blinded, Randomized, Vehicle-Controlled Study of the Efficacy of Moisturizer Containing Licochalcone A, Decanediol, L-Carnitine, and Salicylic Acid for Prevention of Acne Relapse in Asian Population
Salicylic acid · BioMed Research International, 2020Effects of lecithin-based nanoemulsions on skin: Short-time cytotoxicity MTT and BrdU studies, skin penetration of surfactants and additives and the delivery of curcumin
Hydrogenated lecithin · International Journal of Pharmaceutics, 2020Comparative study of efficacy and safety of 45% mandelic acid versus 30% salicylic acid peels in mild-to-moderate acne vulgaris
Mandelic acid · Journal of Cosmetic Dermatology, 2020Treatment of xerosis with a topical formulation containing glyceryl glucoside, natural moisturizing factors, and ceramide
Moisturizing factors nmf, Glyceryl glucoside · The Journal of Clinical and Aesthetic Dermatology, 2012The efficacy of glycolic acid, salicylic acid, gluconolactone, and licochalcone A combined with 0.1% adapalene vs adapalene monotherapy in mild-to-moderate acne vulgaris: a double-blinded within-person comparative study
Gluconolactone, Glycolic acid · Clinical, Cosmetic and Investigational Dermatology, 2019Sunscreens and Cosmetic Formulations Containing Ascorbyl Tetraisopalmitate and Rice Peptides for the Improvement of Skin Photoaging: A Double-blind, Randomized Placebo-controlled Clinical Study
Tetrahexyldecyl ascorbate · Photochemistry and Photobiology, 2021Clinical evidence of the efficacy and safety of a new 3-in-1 anti-aging topical night serum-in-oil containing melatonin, bakuchiol, and ascorbyl tetraisopalmitate: 103 females treated from 28 to 84 days
Tetrahexyldecyl ascorbate · Journal of Cosmetic Dermatology, 2019Efficacy of a topical gel containing chitosan, chlorhexidine, allantoin and dexpanthenol for pain and inflammation control after third molar surgery: A randomized and placebo-controlled clinical trial
Allantoin, Panthenol · Medicina Oral, Patologia Oral Y Cirugia Bucal, 2020A comparative study of gluconolactone versus benzoyl peroxide in the treatment of acne
Gluconolactone · The Australasian Journal of Dermatology, 1992Systematic Study of Paeonol/Madecassoside Co-Delivery Nanoemulsion Transdermal Delivery System for Enhancing Barrier Repair and Anti-Inflammatory Efficacy
Centella asiatica leaf extract · Molecules, 2023Characterization of Acne-Prone Skin with Reflectance Confocal Microscopy and Optical Coherence Tomography and Modifications Induced by Topical Treatment and Probiotic Supplementation
Hydroxypinacolone retinoate · Journal of Clinical Medicine, 2023Anti-Wrinkle Efficacy of Cross-Linked Hyaluronic Acid-Based Microneedle Patch with Acetyl Hexapeptide-8 and Epidermal Growth Factor on Korean Skin
Acetyl hexapeptide-8 · Annals of Dermatology, 2019The pivotal role of Bifida Ferment Lysate on reinforcing the skin barrier function and maintaining homeostasis of skin defenses in vitro
Bifida ferment filtrate · Journal of Cosmetic Dermatology, 2023Biomimetic hyaluronic acid-stabilized zinc oxide nanoparticles in acne treatment: A preclinical and clinical approach
Zinc · Journal of Controlled Release, 2025Fatty acids based α-Tocopherol loaded nanostructured lipid carrier gel: In vitro and in vivo evaluation for moisturizing and anti-aging effects
Vitamin e · Journal of Cosmetic Dermatology, 2020Efficacy of a multitargeted, salicylic acid-based dermocosmetic cream compared to benzoyl peroxide 5% in Acne vulgaris: Results from a randomized study
Salicylic acid · Journal of Cosmetic Dermatology, 2024A Lipid Mixture Enriched by Ceramide NP with Fatty Acids of Diverse Chain Lengths Contributes to Restore the Skin Barrier Function Impaired by Topical Corticosteroid
Ceramide np · Skin Pharmacology and Physiology, 2022Preparation and evaluation of anti-wrinkle cream containing saffron extract and avocado oil
Avocado oil · Journal of Cosmetic Dermatology, 2020Chemical peels for acne vulgaris: a systematic review of randomised controlled trials
Mandelic acid · BMJ Open, 2018A dermocosmetic containing bakuchiol, Ginkgo biloba extract and mannitol improves the efficacy of adapalene in patients with acne vulgaris: result from a controlled randomized trial
Bakuchiol · Clinical, Cosmetic and Investigational Dermatology, 2015Efficacy of a topical serum containing L-ascorbic acid, neohesperidin, pycnogenol, tocopherol, and hyaluronic acid in relation to skin aging signs
Vitamin e · Journal of Cosmetic Dermatology, 2022Antioxidant-based topical formulations influence on the inflammatory response of Japanese skin: A clinical study using non-invasive techniques
Tetrahexyldecyl ascorbate · European Journal of Pharmaceutics and Biopharmaceutics, 2017Efficacy and safety of moisturizer containing 5% panthenol, madecassoside, and copper-zinc-manganese versus 0.02% triamcinolone acetonide cream in decreasing adverse reaction and downtime after ablative fractional carbon dioxide laser resurfacing: A split-face, double-blinded, randomized, controlled trial
Centella asiatica leaf extract · Journal of Cosmetic Dermatology, 2019Retaining Skin Barrier Function Properties of the Stratum Corneum with Components of the Natural Moisturizing Factor-A Randomized, Placebo-Controlled Double-Blind In Vivo Study
Moisturizing factors nmf · Molecules, 2021A Salicylic Acid-Based Dermocosmetic is Effective as an Adjunct to Benzoyl Peroxide for Mild to Moderate Acne and as Monotherapy in Maintenance Post Benzoyl Peroxide
Salicylic acid · Journal of Drugs in Dermatology, 2023Effects of 1,3-propanediol associated, or not, with butylene glycol and/or glycerol on skin hydration and skin barrier function
Propanediol · International Journal of Cosmetic Science, 2024Topical application of jojoba (Simmondsia chinensis L.) wax enhances the synthesis of pro-collagen III and hyaluronic acid and reduces inflammation in the ex-vivo human skin organ culture model
Jojoba seed oil · Frontiers in Pharmacology, 2024Assessment of the Benefit of a Deep Cleansing Gel Containing Salicylic Acid 2%, Zinc Gluconate 0.2% and Lipohydroxy Acids 0.05% in Patients with Mild to Moderate Truncal Acne: Results from an Exploratory Study
Zinc gluconate · Clinical, Cosmetic and Investigational Dermatology, 2023Development of stable tocopherol succinate-loaded ethosomes to enhance transdermal permeation: In vitro and in vivo characterizations
Vitamin e · Journal of Cosmetic Dermatology, 2022Antiacne and antiblotch activities of a formulated combination of Aloe barbadensis leaf powder, Garcinia mangostana peel extract, and Camellia sinensis leaf extract
Camellia sinensis leaf extract · Clinical, Cosmetic and Investigational Dermatology, 2019Whitening effect of alpha-bisabolol in Asian women subjects
Bisabolol · International Journal of Cosmetic Science, 2010Expanding the anti-inflammatory potential of Moringa oleifera: topical effect of seed oil on skin inflammation and hyperproliferation
Moringa seed oil · Journal of Ethnopharmacology, 2020Positive and ecobiological contribution in skin photoprotection of ectoine and mannitol combined in vivo with UV filters
Ectoin · Journal of Cosmetic Dermatology, 2024New clinical approach in facial mild-moderate acne: Re-stabilization of skin microbiota balance with a topical biotechnological phytocomplex
Succinic acid · Journal of Cosmetic Dermatology, 2024Evaluation of moisturizing and irritation potential of sacha inchi oil
Plukenetia volubilis seed oil · Journal of Cosmetic Dermatology, 2020Effect of a botanical cleansing lotion on skin sebum and erythema of the face: A randomized controlled blinded half-side comparison
Willow bark extract · Journal of Cosmetic Dermatology, 2019Anti-Inflammatory Effect of a Novel Topical Herbal Composition (VEL-091604) Consisting of Gentian Root, Licorice Root and Willow Bark Extract
Willow bark extract · Planta Medica, 2019An evaluation of the effect of a topical product containing salicin on the visible signs of human skin aging
Willow bark extract · Journal of Cosmetic Dermatology, 2010The synergistic effect of retinyl propionate and hydroxypinacolone retinoate on skin aging
Hydroxypinacolone retinoate · Journal of Cosmetic Dermatology, 2023A randomized, double-blind, vehicle-controlled study of a preparation containing undecylenoyl phenylalanine 2% in the treatment of solar lentigines
Undecylenoyl phenylalanine · Clinical and Experimental Dermatology, 2010Repair of acetone- and sodium lauryl sulphate-damaged human skin barrier function using topically applied emulsions containing barrier lipids
Phytosphingosine · Journal of the European Academy of Dermatology and Venereology, 2002Squalane as a Promising Agent Protecting UV-Induced Inhibition of Collagen Biosynthesis and Wound Healing in Human Dermal Fibroblast
Squalane · Molecules, 2025Betula alba Bark Extract and Empetrum nigrum Fruit Juice, a Natural Alternative to Niacinamide for Skin Barrier Benefits
Betula alba juice · International Journal of Molecular Sciences, 2022A clinical evaluation of the efficacy and tolerability of a novel topical antioxidant formulation featuring vitamin C, astaxanthin, and fermented turmeric
Astaxanthin · Journal of Cosmetic Dermatology, 2023Clinical Development and Evaluation of a Multi-Component Dissolving Microneedle Patch for Skin Pigmentation Disorders
3-o-ethyl ascorbic acid · Polymers, 2023Development of solid lipid microparticles (SLMs) containing asiatic acid for topical treatment of acne: Characterization, stability, in vitro and in vivo anti-acne assessment
Centella asiatica leaf extract · International Journal of Pharmaceutics, 2024Synergetic Effects of Aloe Vera Extract with Trimethylglycine for Targeted Aquaporin 3 Regulation and Long-Term Skin Hydration
Aloe barbadensis flower extract · Molecules, 2024Fractional microneedle radiofrequency with the application of vitamin C, E, and ferulic acid serum for neck skin rejuvenation: a prospective, double-blinded, split-neck, placebo-controlled trial
Ferulic acid · The Journal of Dermatological Treatment, 2025Lipid ingredients in moisturizers can modulate skin responses to UV in barrier-disrupted human skin in vivo
Phytosphingosine · Journal of Dermatological Science, 2012Epigallocatechin Gallate Enzymatic Alpha Glucosylation Potentiates Its Skin-Lightening Activity-Involvement of Skin Microbiota
Camellia sinensis leaf extract · Molecules, 2024Salicyloyl-phytosphingosine: a novel agent for the repair of photoaged skin
Phytosphingosine · International Journal of Cosmetic Science, 2007Randomized prospective study of low-dose isotretinoin alone and combination with salicylic acid and mandelic peel against acne tarda
Mandelic acid · Journal of Cosmetic Dermatology, 2022Depth-dependent hydration dynamics in human skin: Vehicle-controlled efficacy assessment of a functional 10% urea plus NMF moisturizer by near-infrared confocal spectroscopic imaging (KOSIM IR) and capacitance method complemented by volunteer perception
Moisturizing factors nmf · Skin Research and Technology, 2022Effect of hydroxypropyl-β-cyclodextrin in fluid and semi-solid submicron emulsions on physiological skin parameters during regular in vivo application
Cyclodextrin · International Journal of Cosmetic Science, 2021Emulgels Containing Perilla frutescens Seed Oil, Moringa oleifera Seed Oil, and Mixed Seed Oil: Microemulsion and Safety Assessment
Moringa oleifera seed oil · Polymers, 2022Influence of vitamin E acetate on stratum corneum hydration
Tocopheryl acetate · Arzneimittel-Forschung, 1998A new topical biotechnological phytocomplex for truncal mild-moderate acne restores skin microbiota balance
Succinic acid · Skin Research and Technology, 2024Assessment of the efficacy and safety of a new complex skin cream in Asian women: A controlled clinical trial
Hydroxyresveratrol · Journal of Cosmetic Dermatology, 2017A randomized controlled trial to compare the effectiveness and safety of adsorbent lotion containing tapioca starch, spent grain wax, Butyrospermum parkii extract, argania spinosa kernel oil, aloe barbadensis, rosehip oil, and allantoin with a low-potency topical corticosteroid in the treatment of intertrigo
Shea butter · Journal of Cosmetic Dermatology, 2022Lactobionic acid in a natural alkylpolyglucoside-based vehicle: assessing safety and efficacy aspects in comparison to glycolic acid
Pha polyhydroxy acid · Journal of Cosmetic Dermatology, 2010Evaluation of the Efficacy and Safety of a Panthenol-Enriched Mask for Skin Barrier Recovery After Facial Laser Treatment: Results of a Double-Blind Randomized Controlled Study
Panthenol · Journal of Cosmetic Dermatology, 2025Moisturizing Effects of Diglycerol Combined with Glycerol on Human Stratum Corneum
Diglycerin · Journal of Oleo Science, 2016Preparation and characterization of astaxanthin-loaded biodegradable polyhydroxybutyrate (PHB) microbeads for personal care and cosmetic applications
Astaxanthin · International Journal of Biological Macromolecules, 2024Efficacy and Tolerability of Stable Hybrid Cooperative Complexes of High- and Low-Molecular Weight Hyaluronic Acid in Asian Patients: An Open-Label Study
Hydrolyzed hyaluronic acid · Aesthetic Plastic Surgery, 2026Antioxidant and membrane-protective effects of the 3-O-ethyl ascorbic acid-cannabigerol system on UVB-irradiated human keratinocytes
3-o-ethyl ascorbic acid · Free Radical Biology & Medicine, 2025The anti wrinkle efficacy of synthetic hexapeptide (Argireline) in Chinese Subjects
Acetyl hexapeptide-8 · Journal of Cosmetic and Laser Therapy, 2013Tocopherol succinate-loaded ethosomal gel synthesized by cold method technique: Deeper biophysical characterizations for translational application on human skin
Vitamin e · Journal of Cosmetic Dermatology, 2024Poly-γ-Glutamic Acid from a Novel Bacillus subtilis Strain: Strengthening the Skin Barrier and Improving Moisture Retention in Keratinocytes and a Reconstructed Skin Model
Polyglutamic acid · International Journal of Molecular Sciences, 2025Effects of a Postbiotic Saccharomyces and Lactobacillus Ferment Complex on the Scalp Microbiome of Chinese Women with Sensitive Scalp Syndrome
Lactobacillus ferment · Clinical, Cosmetic and Investigational Dermatology, 2023Clinical study of a spray containing birch juice for repairing sensitive skin
Betula alba juice · Archives of Dermatological Research, 2023Effect of an Emollient Emulsion Containing 15.0% of Caprylic/Capric Triglyceride on the Urocanic Acid of the Stratum Corneum
Caprylic capric triglyceride · Life, 2023Hippophae rhamnoides oil-in-water (O/W) emulsion improves barrier function in healthy human subjects
Hippophae rhamnoides oil · Pakistan Journal of Pharmaceutical Sciences, 2014Nanostructured Lipid Carrier Based Gel Containing α-Tocopherol and α-Tocopheryl Acetate for Synergistic Cutaneous Antiaging Efficacy
Tocopheryl acetate · Scientific Reports, 2025Thermostable hyaluronic acid-based dissolving microneedles with high-loading capacity: design, optimization, and transdermal delivery of anti-aging ingredients
3-o-ethyl ascorbic acid · International Journal of Biological Macromolecules, 2026Prospective randomized double-blind comparative study of topical acetyl zingerone with tetrahexyldecyl ascorbate versus tetrahexyldecyl ascorbate alone on facial photoaging
Tetrahexyldecyl ascorbate · Journal of Cosmetic Dermatology, 2024Efficacy of Topical Hydroxypinacolone Retinoate-Peptide Product Versus Fractional CO2 Laser in Facial Aging
Hydroxypinacolone retinoate · Journal of Cosmetic Dermatology, 2025Safety assessment on comedogenicity of dermatological products containing d-alpha tocopheryl acetate in Asian subjects: A double-blind randomized controlled trial
Tocopheryl acetate, Tocopheryl acetate vitamin e · Contemporary Clinical Trials Communications, 2021Rapid and Visible Efficacy of a Dermocosmetic in Acne Patients With Fair Skin Phototypes: Results of a Randomized Split-Face Study
Zinc gluconate · Journal of Cosmetic Dermatology, 2026A Randomized Controlled Trial of the Genistein Plus Bakuchiol and Vitamins (GEN+) Product for Male Facial Skin: Effects on Skin Appearance and Properties
Bakuchiol · Skin Research and Technology, 2026A polyhydroxy acid skin care regimen provides antiaging effects comparable to an alpha-hydroxyacid regimen
Pha polyhydroxy acid · Cutis, 2004Split-face evaluation: Gluconolactone plus oxybrasion versus gluconolactone plus microneedling. The effects on skin parameters
Gluconolactone · Skin Research and Technology, 2023Efficacy of a Topical Formulation on Skin Hydration and Barrier Function in Individuals With Xerosis: A 28-Day Randomized, Split-Leg, Untreated-Controlled Trial
Dipotassium glycyrrhizate · Journal of Cosmetic Dermatology, 2026Efficacy and safety of combination cream of stimu-tex AS™ (spent grain wax, Argania Spinosa Kernel oil, Butyrospermum Parkii (shea butter) extract), and saccharide isomerate after fractional CO2 laser procedure: split-face, double blinded, randomized controlled trial
Shea butter · Lasers in Medical Science, 2025Prospective, Randomized, Double-Blind Assessment of Supramolecular Bakuchiol and Terminalia Chebula Extract for Facial Photoaging in Chinese Sensitive Skin Population
Bakuchiol · Health Science Reports, 2025Targeting Circadian Rhythm for the Regulation of Skin Collagen Metabolism
Palmitoyl tripeptide-1 · Journal of Cosmetic Dermatology, 2026Preclinical Safety Evaluation of Dual Drug-Loaded Nanolipidic Carriers of Dissolvable Patches: In-Vitro and In-Vivo Safety Assessment
Tetrahydrodiferuloylmethane · Molecular Pharmaceutics, 2025Acai Oil-Based Organogel Containing Hyaluronic Acid for Topical Cosmetic: In Vitro and Ex Vivo Assessment
Euterpe oleracea fruit extract · Pharmaceutics, 2024