Medicube PDRN Pink Peptide Serum for dry skin
Niacinamide
Hydrolyzed Collagen
Sodium DnaHigh
- HighDry Skin Fit
- HighEffectiveness
- HighSafety
A great choice for dry skin; a few moisturizers fit it even better.
- Clinical, Cosmetic and Investigational Dermatology, 2017
- International Journal of Cosmetic Science, 2013
This fit is calculated for the concerns frequently associated with dry skin: flakiness, tightness, dehydration, fine lines, and wrinkles. For scores and recommendations based on your full skin profile, including your 12D face scan results and any goals or preferences you have, please use the Lovi app.
Page built Nov 8, 2026How the Fit score works
Lovi Assistant explains
- Highly suitable for your dry skin as hyaluronic acid and glycerin provide excellent humectant action, while hydrolyzed collagen supports barrier repair. Salmon egg extract and sodium DNA further enhance hydration and plumpness, addressing your dry or flaky skin concerns effectively.
- Niacinamide offers additional benefits for skin tone and texture, complementing the primary moisturizing ingredients.
- The product is safe for your skin, with no harsh or prohibited ingredients that could cause irritation.
How to apply
- Could be used as part of your AM or PM routine. Start using it 3 times a week and work your way up to daily use.
- Apply your moisturizer after your toner and before your sunscreen in the morning. At night, use it as the final step after your serum.
- Gently press a small amount of the moisturizer into your skin. Avoid rubbing to keep your dry skin happy.
- Apply the moisturizer on slightly damp skin to help lock in extra hydration. This is great for soothing dry and flaky areas .
- Avoid the sensitive eye area and do a patch test before your first use .
People Say
★4.7Overall rating based on 2.1k+ reviewsBased on a very large amount of data, this serum is highly praised for delivering intense hydration and a radiant "glass skin" glow, with users frequently reporting immediate improvements in skin plumpness and elasticity. The viscous texture is often noted for its barrier-repairing qualities. A polarizing feature is the distinct scent, described as floral and fishy, which some users find unpleasant.
Highlights
Deep hydration Mostly Mentioned
- “skin feels bouncier and hydrated”
- “keeps it plump for hours”
- “wake up with soft, plump skin”
- “deeply moisturized underneath”
Radiant glow Often Mentioned
- “healthy, dewy glow”
- “creates a natural inner glow”
- “skin looks radiant”
- “glass skin effect”
Smoother texture Often Mentioned
- “skin feels smoother”
- “refined skin texture”
- “fine lines look softer”
- “makeup applies better”
Soothing and gentle Sometimes Noted
- “no tingling or burning”
- “calmed redness”
- “zero irritation on sensitive skin”
- “feels gentle and soothing”
Unpleasant scent Sometimes Noted
- “slightly fishy smell”
- “strong floral fragrance”
- “scent is underwhelming”
- “can't get past the smell”
Caused breakouts Rarely Noted
- “small pimple appeared”
- “broke me out”
- “caused acne”
- “bumps on cheek”
Small quantity Rarely Noted
- “runs out pretty quickly”
- “wish they offered a larger version”
- “small bottle for the price”
Sticky finish Rarely Noted
- “slight sticky feeling”
- “heavy finish”
- “tacky residue”
- “feels a bit sticky”
Sources: lovi.care, oliveyoung.com, iherb.com, ulta.com, medicube.us, youtube.com, and more
Questions and answers
What makes medicube PDRN Pink Peptide Serum a great fit for dry skin?
This serum is a great fit for dry skin because hyaluronic acid and glycerin bring in deep moisture, while hydrolyzed collagen helps repair the skin barrier. Salmon egg extract and sodium DNA add extra hydration to keep flaky skin looking plump and smooth.
Clinical, Cosmetic and Investigational Dermatology, 2017International Journal of Cosmetic Science, 2013
Which ingredients make this serum a good fit for dry skin?
This serum is a great fit for dry skin because hyaluronic acid and glycerin draw in moisture while hydrolyzed collagen helps repair your skin barrier. Salmon egg extract and sodium DNA add extra plumpness and hydration to tackle flaky patches, and niacinamide smooths out your skin texture.
Clinical, Cosmetic and Investigational Dermatology, 2017International Journal of Cosmetic Science, 2013
What does Niacinamide do for dry skin?
Niacinamide helps dry skin by strengthening the skin barrier, increasing hydration, and reducing water loss. It supports ceramide production and helps keep the surface smooth and calm. This ingredient tends to be very well tolerated and is unlikely to irritate dry skin.
Journal of Cosmetic Dermatology, 2004Journal of Cosmetic Dermatology, 2026
What does Hydrolyzed Collagen do for dry skin?
Hydrolyzed Collagen helps improve skin moisture and keeps dry skin hydrated. Regular use may also reduce wrinkles and make the skin feel more smooth and elastic.
Where does this serum go in a skincare routine for dry skin?
This serum goes in the evening routine after cleansing and before moisturizing, as this timing keeps things simple and safe around sun exposure. Using a treatment at night helps deliver key ingredients like hyaluronic acid and glycerin to boost hydration and plumpness in dry skin.
Clinical, Cosmetic and Investigational Dermatology, 2017The Journal of Dermatological Treatment, 2022
Can I use this serum with retinol, and in what order?
You can use this serum with retinol by applying the serum first to give your skin a boost of hydration and help keep it calm. Follow with your retinol once the serum sinks in, as using a supportive moisturizing treatment beforehand is very likely to help reduce dryness and irritation.
How often should I use this serum?
This serum is a great fit for your dry skin and is meant to be used in your evening routine. Daily application helps boost moisture, plumpness, and barrier repair.
Health Science Reports, 2021Clinical, Cosmetic and Investigational Dermatology, 2017
Can this serum clog pores, cause breakouts or purging for dry skin?
This serum is unlikely to cause breakouts for dry skin as it has a safe profile with no harsh ingredients. Reviewers rarely mention breakouts, and its moisturizing ingredients help keep skin calm and smooth.
Can I use this serum around the eyes or on my body?
You can use this moisturizing treatment around your eyes and on your body, as it has a very safe profile and is unlikely to cause irritation. Hyaluronic acid and glycerin in the formula help keep these delicate areas plump and comfortable, while salmon egg extract supports hydration.
Clinical, Cosmetic and Investigational Dermatology, 2017International Journal of Cosmetic Science, 2013
Is this serum fragrance-free and alcohol-free?
Yes, it has no fragrance and no drying alcohol.
What the research says
A single application of a moisturizing fluid containing hyaluronic acid 1%, glycerin 5%, and Centella asiatica stem cells extract significantly increased skin hydration by 29% and reduced transepidermal water loss at 24 hours compared to baseline and an untreated control site in twenty healthy women.
Clinical, Cosmetic and Investigational Dermatology, 2017Treatment with salmon egg extract at concentrations of 1% and 5% significantly improved wrinkles, pigmentation, redness, brightness, and hydration in 66 healthy female volunteers in a dose- and time-dependent manner compared to baseline.
International Journal of Cosmetic Science, 2013Niacinamide significantly decreased hyperpigmentation and increased skin lightness compared with vehicle alone after 4 weeks of use in women by inhibiting melanosome transfer.
The British Journal of Dermatology, 2002Topical post-laser application of human adipocyte-derived mesenchymal stem cell media combined with niacinamide significantly improved wrinkle index, melanin index, patient satisfaction, and investigator esthetic improvement scores compared to vehicle cream in patients with aging skin.
Journal of Cosmetic Dermatology, 2021Topical nicotinamide prevented solar-simulated UV-induced immunosuppression in healthy volunteers, and men experienced immunosuppression at solar-simulated UV doses three times lower than those required for women.
The Journal of Investigative Dermatology, 2008Topical 5% niacinamide applied twice daily for 12 weeks reduced fine lines and wrinkles, hyperpigmented spots, red blotchiness, and skin sallowness, and improved skin elasticity compared to vehicle control in 50 female white subjects with facial photoaging.
Dermatologic Surgery, 2005Topical 2% niacinamide significantly decreased sebum excretion rate in Japanese individuals and casual sebum levels in Caucasian individuals compared to placebo or baseline.
Journal of Cosmetic and Laser Therapy, 2006Topical application of TAC/Collagen postbiotics gel improved skin moisture score and inflammation index, and reduced porphyrins and brown spots in 20 volunteers with acne vulgaris.
Journal of Cosmetic Dermatology, 2022Topical collagen tripeptide application improved skin wrinkles, elasticity, and density while reducing advanced glycated end products in 22 Asian women over 4 weeks.
International Journal of Molecular Sciences, 2022Marine collagen extracted from Greenland halibut skin showed a non-cytotoxic effect on fibroblast cells and provided a slight skin hydration effect when incorporated into cosmetic hydrogel formulations at dosages of 0.1, 0.25, and 0.5% in 23 healthy volunteers.
Marine Drugs, 2023Topical application of Low-Peony PDRN enhanced barrier recovery and improved periorbital skin elasticity in human subjects.
International Journal of Molecular Sciences, 2025Polydeoxyribonucleotide promotes skin regeneration by increasing ERK phosphorylation, collagen accumulation, and cell proliferation and migration in fibroblasts while inhibiting ERK phosphorylation and inflammatory cytokine expression in keratinocytes.
Molecular Medicine Reports, 2023A topical mixture of polydeoxyribonucleotide, vitamin C, and niacinamide delivered via a microneedling therapy system decreased skin pigmentation and increased skin elasticity by attenuating melanogenesis and the destruction of collagen and elastin fibers in a UV-B-radiated animal model.
Molecules, 2022
Ingredients
Water, Disodium Edta, Niacinamide, Hydrolyzed Collagen, Sodium Dna, Milt Extract, Copper Tripeptide-1, Acetyl Hexapeptide-8, Palmitoyl Pentapeptide-4, Palmitoyl Tripeptide-1, Palmitoyl Tetrapeptide-7, Butylene Glycol, 1,2-Hexanediol, Glycerin, Dipropylene Glycol, Polyglycerin-3, Glyceryl Acrylate Acrylic Acid Copolymer, Pvm Ma Copolymer, Hyaluronic Acid, Ethylhexylglycerin, Glycereth-26, Adenosine, Acrylates C10-30 Alkyl Acrylate Crosspolymer, Isopropyl Myristate, Ubiquinone, Caprylyl Glycol, Tromethamine, Sodium Acrylate Sodium Acryloyldimethyl Taurate Copolymer, Polyisobutene, Caprylyl Capryl Glucoside, Sorbitan Oleate, Atelocollagen, Salmon Egg Extract
Behind this fit score
Lovi calculates every fit score from the full ingredient list with brand-independent rules our dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update.
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Co-founder, Medical Director
Cosmetic chemist, cosmetologist, aesthetic products developer
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Co-founder, CEO and CTO
PhD in computer science, 3x US patent holder, ex-Google, ex-Yandex
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Dr. Sofía Perea Pérez, MD, MSc
Medical Board
Aesthetic medicine practitioner, MSc in Longevity and Anti-Aging Medicine
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Medical Board
Specialist dermatologist, MBBS, MD, IFAAD
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Medical Board
Cosmetic chemist, SCS, IFSCC member
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Medical Board, Medical Advisor
Dermatology MD
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Elina Nazarenko, MD
Medical Board
Dermatology and diagnostic consultant
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Victoria Derkova, MS
Medical Board
Cosmetic chemist, cosmetic development technologist
How does it fit your skin?
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