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Medicube PDRN Pink Peptide Ampoule for combination skin

Rated by Lovi · Unbiased, science-based skincare AI trained on real user outcomes

Medicube PDRN Pink Peptide Ampoule

Average

  • HighCombination Skin Fit
  • AverageEffectiveness
  • HighSafety

Works for combination skin; other moisturizers fit it better.

This fit is calculated for the concerns frequently associated with combination skin: an oily T-zone, enlarged pores, and dry cheeks. For scores and recommendations based on your full skin profile, including your 12D face scan results and any goals or preferences you have, please use the Lovi app.

Page built Nov 8, 2026How the Fit score works

Lovi Assistant explains

  • Highly suitable for your combination skin, this product utilizes niacinamide for seboregulation and hyaluronic acid for humectant action, offering good benefits for oil control and hydration.
  • The inclusion of Curcuma Longa Root Extract provides soothing properties that can help with oily shine, complementing the general skincare benefits.
  • The safety profile is excellent, with no risks of irritation for your combination skin due to the absence of prohibited or harsh ingredients.

How to apply

  • Use this moisturizer in your AM and PM routine every day to control shine. Always pair with SPF in the morning.
  • Apply this moisturizer after your cleanser and toner, right before your morning SPF.
  • Gently press a small amount of the moisturizer into your skin and avoid harsh rubbing. Let it ⏳absorb for a minute.
  • Apply the moisturizer on slightly damp skin to help it lock in moisture better. This keeps your combination skin balanced.
  • Avoid the eye area when applying the moisturizer. Do a patch test before your first use.

People Say

★4.7Overall rating based on 2.5k+ reviews

Based on a very large amount of data, users consistently report that this ampoule delivers a "glass skin" effect, providing deep hydration and a noticeable plumping effect that benefits dry and aging skin. While it is widely praised for smoothing texture and soothing sensitive skin, results regarding blemish fading are mixed and take longer to appear.

Highlights

  • Deep hydration Mostly Mentioned
    • “skin feels bouncier”
    • “deeply moisturized from within”
    • “plump and radiant”
    • “eliminated deep dryness”
  • Radiant glow Mostly Mentioned
    • “glass skin glow”
    • “healthy dewy look”
    • “complexion looks clearer”
    • “natural inner glow”
  • Fast absorption Often Mentioned
    • “absorbs quickly”
    • “no greasy residue”
    • “lightweight formula”
    • “glides onto skin beautifully”
  • Noticeable fragrance Sometimes Noted
    • “strong rosy scent”
    • “smell isn't my thing”
    • “wish it was fragrance-free”
    • “scent is polarizing”
  • Small volume Sometimes Noted
    • “runs out quickly”
    • “30ml is too small”
    • “pricey for the size”
    • “wish they offered a larger version”
  • Soothing and gentle Sometimes Noted
    • “no irritation”
    • “calmed redness”
    • “good for sensitive skin”
    • “gentle and soothing”
  • Minor breakouts Rarely Noted
    • “small pimple appeared”
    • “caused blemishes on chin”
    • “broke me out slightly”
    • “congestion on forehead”
  • Slight stickiness Rarely Noted
    • “tacky film”
    • “slight sticky feeling”
    • “residue left behind”
    • “hair sticks to face”

Sources: lovi.care, oliveyoung.com, yesstyle.com, hwahae.co.kr, amazon.co.uk, youtube.com, and more

Questions and answers

How well does medicube PDRN Pink Peptide Ampoule work for combination skin?

This product works for combination skin by helping control oil and adding hydration, but other options may fit your skin better. To work best for this skin type, a product needs a rich blend of hydrating and skin-repairing ingredients that balance moisture levels without causing excess oiliness.

Which ingredients make this serum a good fit for combination skin?

This serum works for combination skin because it includes niacinamide to help control oil and hyaluronic acid to provide hydration. It also features soothing ingredients like turmeric root extract to calm oily shine. To be a better fit for this skin type, a product of this type needs additional moisture-locking ingredients like ceramides to keep moisture balanced.

What does Salmon Pdrn do for combination skin?

Salmon PDRN helps balance combination skin by supporting skin barrier recovery and improving overall smoothness without feeling heavy. It may also help keep dry and oily areas calm and resilient.

International Journal of Molecular Sciences, 2025Molecules, 2023

What does Salmon Collagen do for combination skin?

Salmon collagen helps keep combination skin hydrated and smooth while supporting overall firmness. Oral collagen supplements are generally well tolerated and may improve moisture balance and skin elasticity over several weeks.

Journal of Cosmetic Dermatology, 2015Nutrients, 2026

Where does this serum go in a skincare routine for combination skin?

This treatment goes in the evening routine, after cleansing and before moisturizing, to keep things simple and safe around sun exposure. This type of product needs ingredients like niacinamide for oil control and hyaluronic acid for hydration to truly suit combination skin.

Can I use this serum with retinol, and in what order?

You can use this serum with retinol by applying the serum first to hydrate your skin before adding retinol. This combination is unlikely to cause irritation due to its gentle ingredients, but combination skin of this type needs balancing ingredients like niacinamide and hyaluronic acid to keep oil under control while staying smooth.

How often should I use this serum?

You can use this treatment in your evening routine, applying it after cleansing and toning and before moisturizing. Combination skin needs ingredients like hyaluronic acid for hydration and niacinamide for oil control.

Journal of Cosmetic Dermatology, 2020Health Science Reports, 2021

Can this serum clog pores, cause breakouts or purging for combination skin?

This serum is unlikely to clog pores or cause breakouts for combination skin because it has a very safe formula with no harsh or prohibited ingredients that irritate the skin. It also features niacinamide to help balance oil and hyaluronic acid to provide light hydration. To care for combination skin well, a product of this type needs lightweight hydrators and oil-control ingredients that keep the skin clear and comfortable.

Can I use this serum around the eyes or on my body?

You can use this moisturizing treatment around the eyes and on the body because it has a very safe formula with no harsh ingredients. To get the best results on thin areas like the eyes or body skin, this type of product needs hydrating ingredients like hyaluronic acid and soothing plant extracts to keep the skin soft and smooth.

Polymers, 2023

Is this serum fragrance-free and alcohol-free?

Yes, it has no fragrance and no drying alcohol.

What the research says

  • Topical application of Low-Peony PDRN enhanced barrier recovery and improved periorbital skin elasticity in human subjects.

    International Journal of Molecular Sciences, 2025

  • Polydeoxyribonucleotide promotes skin regeneration by increasing ERK phosphorylation, collagen accumulation, and cell proliferation and migration in fibroblasts while inhibiting ERK phosphorylation and inflammatory cytokine expression in keratinocytes.

    Molecular Medicine Reports, 2023

  • A topical mixture of polydeoxyribonucleotide, vitamin C, and niacinamide delivered via a microneedling therapy system decreased skin pigmentation and increased skin elasticity by attenuating melanogenesis and the destruction of collagen and elastin fibers in a UV-B-radiated animal model.

    Molecules, 2022

  • Topical application of TAC/Collagen postbiotics gel improved skin moisture score and inflammation index, and reduced porphyrins and brown spots in 20 volunteers with acne vulgaris.

    Journal of Cosmetic Dermatology, 2022

  • Topical collagen tripeptide application improved skin wrinkles, elasticity, and density while reducing advanced glycated end products in 22 Asian women over 4 weeks.

    International Journal of Molecular Sciences, 2022

  • Marine collagen extracted from Greenland halibut skin showed a non-cytotoxic effect on fibroblast cells and provided a slight skin hydration effect when incorporated into cosmetic hydrogel formulations at dosages of 0.1, 0.25, and 0.5% in 23 healthy volunteers.

    Marine Drugs, 2023

  • Topical application of CoQ10 improves mitochondrial function in aging skin in vivo, combating cellular signs of aging caused by an age-dependent shift to a functionally anaerobic energy metabolism.

    BioFactors, 2008

  • Encapsulating coenzyme Q10 in lipid nanoparticles for topical use improves skin compatibility, protects against degradation, increases skin penetration, and provides controlled release to counteract aging effects.

    Colloids and Surfaces. B, Biointerfaces, 2023

  • Review of topical administration of carotenoids and coenzyme Q10 loaded in lipid nanoparticles highlights their improved bioavailability, chemical stability, skin absorption, and photoprotective effects.

    Antioxidants, 2021

Ingredients

Salmon Pdrn, Salmon Collagen Complex, Ubiquinone, Ocimum Tenuiflorum, Hyaluronic Acid, Niacinamide, Curcuma Longa Root Extract, Adenosine, Ocimum Sanctum Leaf Extract, Peptide Complex, Rose Pdrn Extract Rosa Damascena Sodium Dna Extract

Behind this fit score

Lovi calculates every fit score from the full ingredient list with brand-independent rules our dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update.

  • Nadia Kapleva, MS

    Nadia Kapleva, MS

    Co-founder, Medical Director

    Cosmetic chemist, cosmetologist, aesthetic products developer

  • Alexey Shagraev, PhD

    Alexey Shagraev, PhD

    Co-founder, CEO and CTO

    PhD in computer science, 3x US patent holder, ex-Google, ex-Yandex

  • Dr. Sofía Perea Pérez, MD, MSc

    Dr. Sofía Perea Pérez, MD, MSc

    Medical Board

    Aesthetic medicine practitioner, MSc in Longevity and Anti-Aging Medicine

  • Aishani Shah, MD

    Aishani Shah, MD

    Medical Board

    Specialist dermatologist, MBBS, MD, IFAAD

  • Asya Zubkova, MS

    Asya Zubkova, MS

    Medical Board

    Cosmetic chemist, SCS, IFSCC member

  • Hanna Kurets, MD

    Hanna Kurets, MD

    Medical Board, Medical Advisor

    Dermatology MD

  • Elina Nazarenko, MD

    Elina Nazarenko, MD

    Medical Board

    Dermatology and diagnostic consultant

  • Victoria Derkova, MS

    Victoria Derkova, MS

    Medical Board

    Cosmetic chemist, cosmetic development technologist

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How does it fit your skin?

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QR code: get the Lovi app
Download on theApp Store Get it onGoogle Play