Clarins Double Serum for mature skin

How to apply

Questions and answers

What the research says

• Topical escin promotes angiogenic behavior and enhances adenosine-induced perfusion in humans by activating Wnt signaling via Gsk3beta down-regulation.

  Current Issues in Molecular Biology, 2025

• A topical serum containing vitamin C, vitamin E, and raspberry leaf cell culture extract improved skin color, elasticity, radiance, smoothness, scaliness, and wrinkles compared to the untreated contralateral side in fifty female volunteers.

  Journal of Cosmetic Dermatology, 2020

• Dermatological products containing d-alpha tocopheryl acetate showed non-comedogenic potential with less than a 50% increase in microcomedones in 12 healthy male subjects compared to octyl palmitate.

  Contemporary Clinical Trials Communications, 2021

• Topical application of curcumin or turmeric treats various skin conditions by leveraging antioxidant, anti-inflammatory, and antimicrobial properties.

  Skin Pharmacology and Physiology, 2023

• Topical formulations of curcumin target oxidative damage and inflammation to improve wound healing in animal models.

  Drug Discovery Today, 2017

• A curcumin-loaded spanlastic anti-aging gel utilizing formula F5 incorporated into 2% HPMC E50 demonstrated sustained release action, compatibility, and the ability to penetrate skin layers to a depth of about 112.5 um without signs of irritation.

  Saudi Pharmaceutical Journal, 2024

• Squalane at 0.005-0.015% counteracts UVA-induced oxidative stress, inflammation, and collagen metabolism inhibition while stimulating fibroblast migration in human dermal fibroblasts.

  Molecules, 2025

• Plant-derived squalane protected human dermal fibroblasts against UVA-induced damage by counteracting ROS formation, suppressing apoptosis-related proteins p53, caspase-3, caspase-9, and PARP, and restoring the pro-survival p-Akt/mTOR pathway.

  Antioxidants, 2025

• A repair cream containing Rhealba oat plantlets extract, l-ALA-l-GLU dipeptide, and hyaluronic acid provided immediate relief and was judged by doctors as good or very good in 96.8% of cases for wound healing in 2,363 patients following dermatological acts.

  Clinical, Cosmetic and Investigational Dermatology, 2018

• Topically applied Avena sativa and Avena Rhealba oatmeal extracts significantly reduced skin irritation parameters including a* parameter increase and blood flow increase compared to vehicle in 12 healthy individuals subjected to the sodium lauryl sulfate irritation model.

  Skin Pharmacology and Applied Skin Physiology, 2002

• Colloidal oat extracts diminished pro-inflammatory cytokines in vitro and colloidal oat lotion improved skin dryness, scaling, roughness, and itch intensity in healthy female subjects compared to baseline.

  Journal of Drugs in Dermatology, 2015

• Topical quinoa bioester application upregulated skin barrier proteins and antioxidant enzymes, shifting proteomic profiles to predict lower biological skin ages compared to vehicle-treated skin by median differences of 11 and 16 years for participants under and over 50.

  Communications Biology, 2026

• Quinoa bioester exposure in human reconstructed epidermis tridimensional cell cultures increased the abundance of proteins related to preventing premature aging, homeostasis, tissue regeneration, and protection against ultraviolet radiation and oxidative damage compared to untreated counterparts.

  Scientific Reports, 2020

• Quinoa husk peptide fraction reduces melanin content via Akt signaling and apoptosis pathways in A375 cells and rat skin cells.

  IScience, 2023

• Topical 0.5% silymarin-loaded antioxidant serum applied twice daily significantly reduced clinical acne severity, lesion counts, and melanin pigmentation in 22 Korean acne patients over 4 weeks without associated adverse events.

  Journal of Cosmetic Dermatology, 2023

• Cosmetic eye and facial creams containing palmitoyl peptides, Silybum marianum seed oil, and vitamin E improve facial wrinkles, elasticity, dermal density, and skin tone in healthy volunteers with aged skin after 4 weeks of application compared to pre-application.

  Experimental and Therapeutic Medicine, 2016

• Topical silymarin cream 1.4% showed comparable results to salicylic acid 30% peels in reducing acne severity in 30 patients with mild to moderate acne vulgaris.

  Journal of Cutaneous Medicine and Surgery, 2024

Ingredients

Water, Cetearyl Isononanoate, Glycerin, Isononyl Isononanoate, Caprylic Capric Triglyceride, Pentylene Glycol, Ppg-3 Myristyl Ether, Ethylene Propylene Styrene Copolymer, Dipsacus Sylvestris Extract, Butylene Glycol, Parfum, Phenoxyethanol, Propanediol, Tromethamine, Silybum Marianum Seed Oil, Carbomer, Tocopheryl Acetate, Escin, Chenopodium Quinoa Seed Extract, Ethylhexylglycerin, Squalane, Avena Sativa Kernel Extract Oat Kernel Extract, Theobroma Cacao Extract, Butylene Ethylene Styrene Copolymer, Leontopodium Alpinum Extract, Xanthan Gum, Persea Gratissima Oil Avocado Oil, Caramel, Curcuma Longa Root Extract, Salicyloyl Phytosphingosine, Musa Sapientum Fruit Extract, Salicornia Herbacea Extract, Actinidia Chinensis Fruit Extract, Kalanchoe Pinnata Leaf Extract, Sodium Benzoate, Citric Acid, Myrothamnus Flabellifolia Stem Extract Leaf, Disodium Edta, Tocopherol, Lycium Barbarum Fruit Extract, Maltodextrin, Orthosiphon Stamineus Extract, Hedychium Coronarium Root Extract, Mangifera Indica Leaf Extract, Potassium Sorbate, Pentaerythrityl Tetra-Di-T-Butyl Hydroxyhydrocinnamate, Jania Rubens Extract, Ascorbic Acid, Sodium Citrate, Engelhardtia Chrysolepis Leaf Extract, Ci 14700 Red 4, Callicarpa Japonica Fruit Extract

Behind this fit score

Lovi calculates every fit score from the full ingredient list with brand-independent rules our dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update.