Acetyl hexapeptide-3 and retinoid blend

Rated by Lovi · Unbiased, science-based skincare AI trained on real user outcomes · How the Fit score works

Keep them apart

Use them at different times of day by applying the peptide serum in the morning and the retinoid at night to prevent skin irritation. Using both active ingredients together can cause extra skin irritation and redness because they are both very strong. The shopper can switch to a gentler product strength or wait longer between applying them.

Acetyl hexapeptide-3 products

The Ordinary Multi-Peptide + Copper Peptides 1% Serum
The Ordinary Multi-Peptide + HA Serum
Medik8 Liquid Peptides
La Mer The Treatment Lotion S$238.16
Rhode Peptide Glazing Fluid
The Ordinary Argireline Solution 10%
Good Molecules Super Peptide Serum S$38.42
Clinique Smart Clinical Repair Wrinkle Correcting Serum
La Mer The Renewal Oil S$466.85
Estée Lauder Micro Essence Treatment Lotion
The INKEY List Collagen Peptide Serum
La Mer The Eye Concentrate S$337.38

Retinoid blend products

Sunday Riley A+ High-Dose Retinoid Serum S$119.36

Questions and answers

Can you use acetyl hexapeptide-3 and retinoid blend together?

Keep acetyl hexapeptide-3 and retinoid blend apart because combining them may increase irritation. Instead, alternate their usage by applying the retinoid in the PM and the peptides in the AM.

Which goes first, acetyl hexapeptide-3 or retinoid blend?

Keep acetyl hexapeptide-3 and retinoid blend apart because combined stimulation may increase irritation. Alternate their usage by applying the retinoid in the PM and the peptides in the AM.

Are acetyl hexapeptide-3 and retinoid blend good for sensitive skin?

Acetyl hexapeptide-3 and retinoid blend should be kept apart to avoid increased irritation on sensitive skin. Alternate your routine by using the retinoid in the evening and peptides in the morning.

Research on acetyl hexapeptide-3 and retinoid blend

The anti-wrinkle efficacy of argireline, a synthetic hexapeptide, in Chinese subjects: a randomized, placebo-controlled study
Acetyl hexapeptide-3 · American Journal of Clinical Dermatology, 2013
Anti-Wrinkle Efficacy of Cross-Linked Hyaluronic Acid-Based Microneedle Patch with Acetyl Hexapeptide-8 and Epidermal Growth Factor on Korean Skin
Acetyl hexapeptide-3 · Annals of Dermatology, 2019
The efficacy study of the combination of tripeptide-10-citrulline and acetyl hexapeptide-3. A prospective, randomized controlled study
Acetyl hexapeptide-3 · Journal of Cosmetic Dermatology, 2017
The anti wrinkle efficacy of synthetic hexapeptide (Argireline) in Chinese Subjects
Acetyl hexapeptide-3 · Journal of Cosmetic and Laser Therapy, 2013

Behind this pairing advice

Lovi checks every pairing with brand-independent rules our dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update.

Nadia Kapleva, MS

Co-founder, Medical Director

Cosmetic chemist, cosmetologist, aesthetic products developer
Alexey Shagraev, PhD

Co-founder, CEO and CTO

PhD in computer science, 3x US patent holder, ex-Google, ex-Yandex
Dr. Sofía Perea Pérez, MD, MSc

Medical Board

Aesthetic medicine practitioner, MSc in Longevity and Anti-Aging Medicine
Aishani Shah, MD

Medical Board

Specialist dermatologist, MBBS, MD, IFAAD
Asya Zubkova, MS

Medical Board

Cosmetic chemist, SCS, IFSCC member
Hanna Kurets, MD

Medical Board, Medical Advisor

Dermatology MD
Elina Nazarenko, MD

Medical Board

Dermatology and diagnostic consultant
Victoria Derkova, MS

Medical Board

Cosmetic chemist, cosmetic development technologist

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