La Mer The Eye Concentrate for mature skin

Questions and answers

What the research says

• Argireline treatment twice daily for 4 weeks produced a significant anti-wrinkle effect with 48.9% total efficacy and decreased skin roughness in Chinese subjects compared with 0% efficacy and no decrease in roughness in the placebo group.

  American Journal of Clinical Dermatology, 2013

• Treatment with cross-linked hyaluronic acid-based microneedle patches combined with acetyl hexapeptide-8 or epidermal growth factor significantly improved wrinkles and skin hydration compared to the patch alone in Korean females over 29 days.

  Annals of Dermatology, 2019

• Argireline applied twice daily for 4 weeks achieved a total anti-wrinkle efficiency of 48.9% and notably reduced wrinkle depth compared to placebo in Chinese subjects.

  Journal of Cosmetic and Laser Therapy, 2013

• Treatment with lipid algae extract reduced the level of oxidized proteins in human keratinocytes and stratum corneum skin cells.

  Annals of the New York Academy of Sciences, 2004

• Topical astaxanthin-loaded algae extract hydrogel and lipogel formulations exhibited the highest antioxidant activity and successful in vitro release, suggesting their potential as anti-aging formulations.

  Journal of Cosmetic Dermatology, 2019

• Antarctic marine algae extracts increased cell viability, protected against inflammation, and enhanced the barrier integrity of human intestinal and keratinocyte cell lines damaged by lipopolysaccharide or ultraviolet radiation.

  Marine Drugs, 2022

• Treatment with bone marrow mesenchymal stem cells combined with Cystoseira algae extract significantly improved wound closure, tissue thickness, layer density, and skin elasticity while reducing oxidative indicators, pro-inflammatory cytokines, and immune markers in immunosuppressed rats compared to the control group.

  PloS One, 2024

• Acetyl hexapeptide-3 and tripeptide-10 citrulline demonstrated antiwrinkle efficacy and decreased transepidermal water loss in twenty-four healthy volunteers compared to control groups, though synergistic effects between the two peptides remained unclear.

  Journal of Cosmetic Dermatology, 2017

• Daily topical acetyl hexapeptide-8 showed a trend toward a longer time until return to baseline Jankovic Blepharospasm Rating Scale scores compared to placebo (3.7 months vs. 3.0 months) in 24 patients with blepharospasm receiving botulinum toxin therapy.

  European Journal of Neurology, 2013

• Dissolving microneedles loaded with 3-O-ethyl ascorbic acid and acetyl hexapeptide-8 achieved higher cumulative transdermal delivery than aqueous solutions and significantly reduced photoaging signs while restoring oxidative balance in a UV/D-galactose-induced mouse model.

  International Journal of Biological Macromolecules, 2026

• A topical cosmetic slimming product containing tetrahydroxypropyl ethylenediamine, caffeine, carnitine, forskolin and retinol significantly reduced body circumferences and improved skin aspect compared with placebo in 78 women over 12 weeks.

  International Journal of Cosmetic Science, 2011

• Topical sunscreen formulations containing caffeine combined with UV filters increased in vivo anti-UVB protection by approximately 25% and showed higher SPF values compared to caffeine-free sunscreen, while being well tolerated by the skin of healthy subjects.

  Frontiers in Physiology, 2019

• Caffeine gel combined with choline geranate showed high skin permeation capacity and superior clinical results in cellulite treatment compared to caffeine gel without ionic liquid.

  AAPS PharmSciTech, 2021

• A single application of a moisturizing fluid containing hyaluronic acid 1%, glycerin 5%, and Centella asiatica stem cells extract significantly increased skin hydration by 29% and reduced transepidermal water loss at 24 hours compared to baseline and an untreated control site in twenty healthy women.

  Clinical, Cosmetic and Investigational Dermatology, 2017

• The emollient V0034CR significantly reduced TEWL compared to vehicle and vehicle plus glycerol, and significantly increased corneometry scores compared to vehicle and vehicle plus petrolatum in healthy volunteers with dry skin, demonstrating combined barrier function improvement from petrolatum and hydration improvement from glycerol.

  Journal of Cosmetic Dermatology, 2020

• Ten days of treatment with a cream containing 20% glycerin significantly increased skin hydration measured by corneometer values in 17 healthy volunteers compared to a placebo cream, but showed no influence on transepidermal water loss or skin sensitivity to an irritating surfactant.

  International Journal of Cosmetic Science, 2001

• Application of creams and emulgels containing immortelle extract and hemp oil increased skin hydration and reduced TEWL in 25 healthy volunteers compared to placebo samples and a non-treated control, with emulgels demonstrating enhanced herbal active delivery and better sensory properties than creams.

  Pharmaceutics, 2021

• Polypropylene non-woven fabric impregnated with H. italicum extract using ethanol as a cosolvent demonstrated significantly greater potential for skin protection compared to other investigated samples on artificially irritated human skin without causing irritation or redness.

  Journal of Ethnopharmacology, 2023

• A night cream containing melatonin, carnosine, and Helichrysum italicum extract reduced oxidative stress ex vivo and improved hydration, reduced transepidermal water loss, decreased wrinkles and spots, and lowered skin reactivity in 117 individuals over up to 12 weeks of nightly use.

  Dermatology and Therapy, 2020

Ingredients

Algae Extract, Water, Cyclopentasiloxane, Glycerin, Dimethicone, Vinyl Dimethicone Methicone Silsesquioxane Crosspolymer, Caprylic Capric Triglyceride, Caprylic Capric Myristic Stearic Triglyceride, Yeast Faex Extrait De Levure Extract, Sea Salt Maris Sal Sel Marin, Saccharomyces Copper Ferment, Helichrysum Italicum Extract, Polysilicone-11, Gelidium Cartilagineum Extract, Tourmaline, Polygonum Fagopyrum Seed Extract, Saccharomyces Lysate Extract, Sesamum Indicum Seed Oil, Medicago Sativa Seed Powder, Helianthus Annuus Seedcake Sunflower Seedcake, Prunus Amygdalus Dulcis Seed Meal Seed, Eucalyptus Globulus Oil Leaf Eucalyptus Oil Leaf, Sodium Gluconate, Calcium Gluconate, Copper Gluconate, Magnesium Gluconate, Zinc Gluconate, Tocopheryl Succinate, Niacin, Sesamum Indicum Seed Powder, Corallina Officinalis Extract, Ferrous Gluconate, Glyceryl Triacetyl Ricinoleate, Hydrogenated Oil, Macadamia Ternifolia Seed Oil, Palmitoyl Tetrapeptide-7, Acetyl Hexapeptide-8, Whey Lactis Proteine Du Petit-Lait Protein, Hesperidin Methyl Chalcone, Cyclohexasiloxane, Linoleic Acid, Caffeine, Cholesterol, Tetraacetylphytosphingosine, Sigesbeckia Orientalis Extract, Butylene Glycol, Crithmum Maritimum Extract, Acetyl Glucosamine, Steareth-20, Amino Propyl Ascorbyl Phosphate, Nylon-12, Triethylhexanoin, Avena Sativa Kernel Extract Oat Kernel Extract, Prunus Amygdalus Dulcis Seed Extract, Isononyl Isononanoate, Glycine Soja Protein Soybean Protein, Cetyl Peg Ppg-10 1 Dimethicone, Phytosphingosine, Hydrogenated Polyisobutene, Propylene Glycol Dioctanoate, Calcium Chloride, Sucrose, Dipeptide-2, Dimethicone Crosspolymer, Triethoxycaprylylsilane, Caprylyl Glycol, Trimethylsiloxysilicate, Isododecane, Peg Ppg-18 18 Dimethicone, Silica, Alumina, Parfum, Phenoxyethanol, Mica, Titanium Dioxide Ci 77891

Behind this fit score

Lovi calculates every fit score from the full ingredient list with brand-independent rules our dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update.