Acetyl hexapeptide-3 and retinoid blend
Keep them apart
Use them at different times of day by applying the peptide serum in the morning and the retinoid at night to prevent skin irritation. Using both active ingredients together can cause extra skin irritation and redness because they are both very strong. The shopper can switch to a gentler product strength or wait longer between applying them.
Acetyl hexapeptide-3 products
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The Ordinary
Multi-Peptide + Copper Peptides 1% Serum
€27.95
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The Ordinary
Multi-Peptide + HA Serum
€16.90
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Medik8
Liquid Peptides
€102.00
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La Mer
The Treatment Lotion
€79.90
- Rhode Peptide Glazing Fluid
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The Ordinary
Argireline Solution 10%
€8.96
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Good Molecules
Super Peptide Serum
€23.20
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Clinique
Smart Clinical Repair Wrinkle Correcting Serum
€71.30
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La Mer
The Renewal Oil
€189.00
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Estée Lauder
Micro Essence Treatment Lotion
€109.00
- The INKEY List Collagen Peptide Serum
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La Mer
The Eye Concentrate
€124.58
Retinoid blend products
- Sunday Riley A+ High-Dose Retinoid Serum
Questions and answers
Can you use acetyl hexapeptide-3 and retinoid blend together?
Keep acetyl hexapeptide-3 and retinoid blend apart because combining them may increase irritation. Instead, alternate their usage by applying the retinoid in the PM and the peptides in the AM.
Which goes first, acetyl hexapeptide-3 or retinoid blend?
Keep acetyl hexapeptide-3 and retinoid blend apart because combined stimulation may increase irritation. Alternate their usage by applying the retinoid in the PM and the peptides in the AM.
Are acetyl hexapeptide-3 and retinoid blend good for sensitive skin?
Acetyl hexapeptide-3 and retinoid blend should be kept apart to avoid increased irritation on sensitive skin. Alternate your routine by using the retinoid in the evening and peptides in the morning.
Research on acetyl hexapeptide-3 and retinoid blend
Behind this pairing advice
Lovi checks every pairing with brand-independent rules our dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update.
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Co-founder, Medical Director
Cosmetic chemist, cosmetologist, aesthetic products developer
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Co-founder, CEO and CTO
PhD in computer science, 3x US patent holder, ex-Google, ex-Yandex
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Dr. Sofía Perea Pérez, MD, MSc
Medical Board
Aesthetic medicine practitioner, MSc in Longevity and Anti-Aging Medicine
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Medical Board
Specialist dermatologist, MBBS, MD, IFAAD
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Medical Board
Cosmetic chemist, SCS, IFSCC member
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Medical Board, Medical Advisor
Dermatology MD
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Elina Nazarenko, MD
Medical Board
Dermatology and diagnostic consultant
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Victoria Derkova, MS
Medical Board
Cosmetic chemist, cosmetic development technologist
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