Medik8 Liquid Peptides for mature skin
Acetyl Hexapeptide-8
Palmitoyl Tripeptide-1
Palmitoyl Tetrapeptide-7
Average
- HighNormal Skin Fit
- HighEffectiveness
- HighSafety
Works for mature skin; other serums fit it better.
This fit is calculated for the concerns frequently associated with mature skin: fine lines, wrinkles, and loss of firmness. For scores and recommendations based on your full skin profile, including your 12D face scan results and any goals or preferences you have, please use the Lovi app.
Page built Nov 8, 2026How the Fit score works
Lovi Assistant explains
- Offers moderate benefits for wrinkles and fine lines, as Acetyl Hexapeptide-8 and Palmitoyl Tripeptide-1 support collagen production, while Glycerin and Hyaluronic Acid provide excellent humectant action for your normal skin.
- The formulation is safe for your normal skin due to the absence of prohibited or harsh ingredients.
- This product provides visible anti-aging effects with its plumping and firming properties.
How to apply
- Use this serum in your PM routine. Start by applying it 3 times a week, and work up to daily use if your skin likes it.
- Apply this serum after your toner and before your moisturizer.
- Gently press 2-3 drops of the serum into your skin and let it absorb for a minute.
- You can apply the serum on dry skin for the best results against fine lines.
- Always do a patch test before your first use and avoid the sensitive eye area.
People Say
★4.6Overall rating based on 200+ reviewsUsers consistently praise this serum as a "Botox in a bottle" alternative that delivers immediate hydration and visible plumping, particularly for fine lines on the forehead and around the eyes. It is widely celebrated for its ability to smooth skin texture and restore bounce to dry or mature skin without causing irritation, making it a staple for those targeting early to advanced signs of aging.
Highlights
Deeply hydrating Mostly Mentioned
- “Restores moisture”
- “Eliminates dry patches”
- “Leaves skin dewy”
- “'Glass skin' finish”
Elegant, lightweight texture Often Mentioned
- “Absorbs fast”
- “Non-greasy”
- “Silky feel”
- “Layers perfectly under makeup/SPF”
Visibly plumps and smooths Often Mentioned
- “Reduces fine lines”
- “Softens expression lines”
- “'Botox-like' effect”
- “Improves skin bounce”
High price point Often Mentioned
- “Expensive per bottle”
- “Investment skincare”
- “Pricey for the size”
- “Waiting for sales”
Gentle and non-irritating Sometimes Noted
- “Suitable for sensitive skin”
- “No stinging”
- “Works with retinol”
- “Calms redness”
Packaging fragility Sometimes Noted
- “Glass bottle breaks easily”
- “Dropper issues”
- “Difficult to get last drops”
- “Travel concerns”
Results require patience Rarely Noted
- “Subtle initial changes”
- “Takes weeks for deep wrinkles”
- “Not a 'miracle' for everyone”
Slight tackiness Rarely Noted
- “Can feel sticky if over-applied”
- “Needs time to dry”
- “'Glue-like' texture for some”
Sources: lovi.care, dermstore.com, cultbeauty.com, spacenk.com, medik8.com, amazon.com, and more
Questions and answers
How well does Medik8 Liquid Peptides work for mature skin?
Medik8 Liquid Peptides works moderately well for mature skin, helping to smooth fine lines and plump the skin with peptides and hydrating ingredients. To fit mature skin even better, a product needs exceptionally safe, irritation-free formulas with high concentrations of potent antioxidants, skin-repairing components, and high-quality ingredients that target aging effectively.
American Journal of Clinical Dermatology, 2013Journal of Cosmetic and Laser Therapy, 2013
Which ingredients make this serum a good fit for mature skin?
Acetyl Hexapeptide-8 and Palmitoyl Tripeptide-1 help smooth fine lines by supporting collagen production, while Glycerin and Hyaluronic Acid keep your skin hydrated. To fit mature skin even better, this type of product also needs high concentrations of potent antioxidants and skin-repairing ingredients.
American Journal of Clinical Dermatology, 2013Journal of Cosmetic and Laser Therapy, 2013
What does Argireline do for mature skin?
Argireline helps smooth out lines and makes mature skin look firmer and less rough when used twice a day. It may also help keep skin hydrated, though its penetration is naturally limited.
American Journal of Clinical Dermatology, 2013Journal of Cosmetic and Laser Therapy, 2013
What does Palmitoyl Tripeptide-1 do for mature skin?
Palmitoyl tripeptide-1 helps improve firmness, smooths out wrinkles, and enhances skin brightness when used as part of an anti-aging routine. Studies show that when applied at night or combined with complementary peptides, it supports collagen production to make mature skin look more firm and elastic.
Journal of Cosmetic Dermatology, 2026International Journal of Cosmetic Science, 2026
Where does it go in a skincare routine for mature skin?
This treatment goes in the evening routine after cleansing and before moisturizing. Putting treatments in the evening helps keep things simple and gives extra safety around sun exposure.
Can I use this serum with retinol, and in what order?
Yes, you can use this treatment with retinol by applying the peptide serum first and following with your retinol product. This helps firm and plump your skin while supporting collagen production, though mature skin often responds better to formulas with higher concentrations of specialized anti-aging ingredients.
How often should I use it?
You can use this treatment in the evening as part of your routine for mature skin. This product of this type needs firming peptides like Acetyl Hexapeptide-8 and smoothing ingredients to better target lines and wrinkles on your skin.
American Journal of Clinical Dermatology, 2013Journal of Cosmetic and Laser Therapy, 2013
Can this serum clog pores, cause breakouts or purging for mature skin?
This serum is unlikely to clog pores or cause breakouts for mature skin due to the absence of heavy oils and harsh ingredients. To properly care for mature skin, a product of this type needs firming peptides like Acetyl Hexapeptide-8 and hydrating ingredients like Hyaluronic Acid to smooth fine lines and keep the skin soft.
American Journal of Clinical Dermatology, 2013Clinical, Cosmetic and Investigational Dermatology, 2017
Is it fragrance-free and alcohol-free?
Yes, it has no fragrance and no drying alcohol.
What the research says
Argireline treatment twice daily for 4 weeks produced a significant anti-wrinkle effect with 48.9% total efficacy and decreased skin roughness in Chinese subjects compared with 0% efficacy and no decrease in roughness in the placebo group.
American Journal of Clinical Dermatology, 2013Argireline applied twice daily for 4 weeks achieved a total anti-wrinkle efficiency of 48.9% and notably reduced wrinkle depth compared to placebo in Chinese subjects.
Journal of Cosmetic and Laser Therapy, 2013A single application of a moisturizing fluid containing hyaluronic acid 1%, glycerin 5%, and Centella asiatica stem cells extract significantly increased skin hydration by 29% and reduced transepidermal water loss at 24 hours compared to baseline and an untreated control site in twenty healthy women.
Clinical, Cosmetic and Investigational Dermatology, 2017Topical hyaluronic acid filler serum combined with Botulinum toxin type A lengthened the duration of the toxin's effect in reducing wrinkles compared to Botulinum toxin type A alone.
Dermatologic Therapy, 2022Treatment with cross-linked hyaluronic acid-based microneedle patches combined with acetyl hexapeptide-8 or epidermal growth factor significantly improved wrinkles and skin hydration compared to the patch alone in Korean females over 29 days.
Annals of Dermatology, 2019Acetyl hexapeptide-3 and tripeptide-10 citrulline demonstrated antiwrinkle efficacy and decreased transepidermal water loss in twenty-four healthy volunteers compared to control groups, though synergistic effects between the two peptides remained unclear.
Journal of Cosmetic Dermatology, 2017Daily topical acetyl hexapeptide-8 showed a trend toward a longer time until return to baseline Jankovic Blepharospasm Rating Scale scores compared to placebo (3.7 months vs. 3.0 months) in 24 patients with blepharospasm receiving botulinum toxin therapy.
European Journal of Neurology, 2013Dissolving microneedles loaded with 3-O-ethyl ascorbic acid and acetyl hexapeptide-8 achieved higher cumulative transdermal delivery than aqueous solutions and significantly reduced photoaging signs while restoring oxidative balance in a UV/D-galactose-induced mouse model.
International Journal of Biological Macromolecules, 2026A multi-modal methodology combining MALDI-MSI, in vivo RCM, echography, and histology revealed age-related decreases in extracellular matrix and epidermal-dermal junction proteins and undulation depth, while a blend of palmitoyl oligopeptide and palmitoyl tetrapeptide-7 improved subepidermal low-echogenic band thickness, density, and extracellular matrix structure compared to placebo.
Journal of Cosmetic Dermatology, 2015Chronomodulated daytime application of baicalin and nighttime application of palmitoyl tripeptide-1 synergistically improved skin luminance by 16.29%, nasolabial fold depth by -36.35%, and firmness by 24.35% in 30 female participants.
Journal of Cosmetic Dermatology, 2026Palmitoyl tetrapeptide-7, acetyl hexapeptide-8, palmitoyl tripeptide-1, and palmitoyl tetrapeptide-10 significantly increased type III collagen levels in human dermal fibroblasts following UV exposure, with their combination demonstrating a greater effect in vitro and enhancing type I, III, and IV collagen levels in ex vivo skin tissues compared to individual components.
International Journal of Cosmetic Science, 2026
Ingredients
Water, Glycerin, Acetyl Hexapeptide-8, Palmitoyl Tripeptide-1, Palmitoyl Tetrapeptide-7, Carbomer, Phenoxyethanol, Ethylhexylglycerin, Hyaluronic Acid, Lecithin, Caprylyl Glycol, Disodium Edta, Citric Acid
Behind this fit score
Lovi calculates every fit score from the full ingredient list with brand-independent rules our dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update.
-
Co-founder, Medical Director
Cosmetic chemist, cosmetologist, aesthetic products developer
-
Co-founder, CEO and CTO
PhD in computer science, 3x US patent holder, ex-Google, ex-Yandex
-
Dr. Sofía Perea Pérez, MD, MSc
Medical Board
Aesthetic medicine practitioner, MSc in Longevity and Anti-Aging Medicine
-
Medical Board
Specialist dermatologist, MBBS, MD, IFAAD
-
Medical Board
Cosmetic chemist, SCS, IFSCC member
-
Medical Board, Medical Advisor
Dermatology MD
-
Elina Nazarenko, MD
Medical Board
Dermatology and diagnostic consultant
-
Victoria Derkova, MS
Medical Board
Cosmetic chemist, cosmetic development technologist
How does it fit your skin?
Scan your face, then any product: Lovi shows how well it fits you and what fits even better.