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Lancôme Rénergie H.P.N. 300-Peptide Cream for combination skin

Rated by Lovi · Unbiased, science-based skincare AI trained on real user outcomes

Lancôme Rénergie H.P.N. 300-Peptide Cream

Average

  • AverageCombination Skin Fit
  • HighEffectiveness
  • ConcerningSafety

Works for combination skin; other moisturizers fit it better.

This fit is calculated for the concerns frequently associated with combination skin: an oily T-zone, enlarged pores, and dry cheeks. For scores and recommendations based on your full skin profile, including your 12D face scan results and any goals or preferences you have, please use the Lovi app.

Page built Nov 8, 2026How the Fit score works

Lovi Assistant explains

  • Offers moderate suitability for your combination skin, as niacinamide can help with oil regulation and glycerin provides hydration, though it may not fully address all your concerns.
  • The formulation provides excellent moisturizing and anti-aging benefits through hydrolyzed hyaluronic acid and adenosine, which hydrate and smooth fine lines.

How to apply

  • Use this moisturizer in your AM and PM routine every day to control shine. Always pair with SPF in the morning.
  • Apply this moisturizer after your cleanser and toner, right before your morning SPF.
  • Gently press a small amount of the moisturizer into your skin and avoid harsh rubbing. Let it ⏳absorb for a minute.
  • Apply the moisturizer on slightly damp skin to help it lock in moisture better. This keeps your combination skin balanced.
  • Avoid the eye area when applying the moisturizer. Do a patch test before your first use.

People Say

★4.7Overall rating based on 7.1k+ reviews

Based on a very large amount of data, this rich cream is highly recommended for mature and dry skin, effectively plumping, firming, and smoothing without greasiness, leading to a radiant complexion. Some users noted sensitivity to the fragrance and found the price to be high.

Highlights

  • Luxurious non-greasy texture Mostly Mentioned
    • “rich cream that absorbs instantly”
    • “feels like butter but not oily”
    • “sinks in beautifully”
    • “perfect under makeup”
  • Deep hydration Often Mentioned
    • “skin feels hydrated all day”
    • “no more dry patches”
    • “leaves face feeling soft”
    • “plumps up dehydration lines”
  • Visible anti-aging results Often Mentioned
    • “jawline looks tighter”
    • “fine lines are less visible”
    • “skin feels plumper”
    • “texture is much smoother”
  • High price point Often Mentioned
    • “very expensive for the amount”
    • “hard to justify the cost”
    • “price is a bit steep”
    • “wish it was more affordable”
  • Pleasant fragrance Sometimes Noted
    • “smells absolutely divine”
    • “light and fresh scent”
    • “fragrance is lovely but not overpowering”
    • “luxurious spa smell”
  • Refillable packaging Sometimes Noted
    • “love that it is refillable”
    • “beautiful heavy glass jar”
    • “great sustainable option”
    • “easy to replace the pod”
  • Heavy for oily skin Rarely Noted
    • “too heavy for my oily zone”
    • “made me look greasy”
    • “clogged my pores”
    • “better for night use only”
  • Lack of dramatic results Rarely Noted
    • “didn't see a difference”
    • “just a basic moisturizer”
    • “not enough for very dry skin”
    • “expected more for the price”
  • Skin irritation Rarely Noted
    • “caused a red rash”
    • “skin felt burning”
    • “broke me out in hives”
    • “irritated my sensitive skin”
  • Strong fragrance Rarely Noted
    • “fragrance is too heavy”
    • “smell lingers too long”
    • “perfume irritated my eyes”
    • “wish it was fragrance-free”

Sources: lovi.care, macys.com, ulta.com, lancome-usa.com, walmart.com, sephora.com, and more

Questions and answers

How well does Lancôme Rénergie Cream work for combination skin?

Lancôme Rénergie H.P.N. 300-Peptide Cream offers moderate suitability for combination skin, as niacinamide helps balance oil while glycerin and hyaluronic acid provide hydration. However, a product for this skin needs ingredients that reduce oily shine and deliver hydration without feeling heavy.

Clinical, Cosmetic and Investigational Dermatology, 2017

Which ingredients make this cream a good fit for combination skin?

Niacinamide helps control oil, and glycerin provides hydration for your combination skin. To fit this skin type even better, products need ingredients that balance oil and reduce shine while keeping skin hydrated without feeling heavy.

Clinical, Cosmetic and Investigational Dermatology, 2017

What do Peptides do for combination skin?

Peptides help combination skin by keeping it smooth, supporting firmness, and boosting hydration. They also help reduce the appearance of lines and encourage skin repair, though absorption depends on the formula.

International Journal of Molecular Sciences, 2025Food & Function, 2019

What does Hyaluronic Acid do for combination skin?

Hyaluronic acid is a great fit for combination skin because it quenches dry areas with a boost of hydration while keeping oily zones balanced. Regular use helps smooth out fine lines and makes your skin feel soft and plump without causing irritation.

Dermatology and Therapy, 2021Journal of Drugs in Dermatology, 2011

Where does this cream go in a skincare routine for combination skin?

This moisturizing treatment goes after your cleanser and hydrating toner in the morning routine, or after your evening cleanser and cleansing toner. Combination skin typically needs a lightweight moisturizer and targeted oil-balancing ingredients to keep the T-zone managed while hydrating dry areas.

The Journal of Dermatological Treatment, 2022International Journal of Cosmetic Science, 2020

Can I use this cream with retinol, and in what order?

You can use this cream with retinol by applying it as a moisturizer to help keep your skin hydrated and smooth while using retinol. A moisturizer of this type works best for combination skin when it includes barrier-strengthening ingredients and lightweight hydrators to comfort dry areas while balancing oil.

Cutis, 2006

How often should I use this cream?

You can use this moisturizing treatment twice a day as part of your morning and evening routine. Regular daily application helps keep your skin hydrated and smooth while supporting your skin barrier.

Journal of Cosmetic Dermatology, 2020Health Science Reports, 2021

Can this cream clog pores, cause breakouts or purging for combination skin?

This cream is unlikely to clog pores or cause breakouts for combination skin, though it may not be the most lightweight choice. Combination skin needs a balanced formula with niacinamide and light hydrators that control oil without feeling heavy.

Can I use this cream around the eyes or on my body?

This moisturizing treatment can be used around the eyes and on the body, but it is an average fit for combination skin. Combination skin needs lightweight hydrators and oil-balancing ingredients like niacinamide and hyaluronic acid to stay smooth without feeling heavy.

Is this cream fragrance-free and alcohol-free?

It contains fragrance (benzyl alcohol, geraniol, limonene, and parfum) and drying alcohol (alcohol denat).

What the research says

  • A single application of a moisturizing fluid containing hyaluronic acid 1%, glycerin 5%, and Centella asiatica stem cells extract significantly increased skin hydration by 29% and reduced transepidermal water loss at 24 hours compared to baseline and an untreated control site in twenty healthy women.

    Clinical, Cosmetic and Investigational Dermatology, 2017

  • Adenosine-loaded dissolving microneedle patches showed similar or better efficacy on skin wrinkles, dermal density, elasticity, and hydration compared to adenosine cream in 22 female subjects.

    International Journal of Cosmetic Science, 2018

  • Horse oil-spread and adenosine-loaded dissolving microneedle patches significantly improved skin elasticity, hydration, dermal density, and wrinkles compared with adenosine-loaded dissolving microneedle patches in 20 women without causing adverse events.

    Journal of Cosmetic Dermatology, 2019

  • Topical application of 0.1% hyaluronic acid formulations of different molecular weights led to significant improvements in skin hydration and elasticity, with low-molecular-weight formulations also significantly reducing wrinkle depth in seventy-six female subjects compared to a vehicle control.

    Journal of Drugs in Dermatology, 2011

  • Topical application of hyaluronic acid in conjunction with free gingival graft significantly reduced donor site postoperative pain until day 7 compared to normal saline, with no significant differences in graft dimensions or patient satisfaction.

    Clinical Oral Investigations, 2022

  • Treatment with a hyaluronic acid-containing mouth rinse or topical gel led to significant lesion reduction, pain relief, and normalization of lesion color in adult patients with minor recurrent aphthous stomatitis, with the gel formulation showing an earlier healing onset at 3 days.

    BMC Oral Health, 2019

  • Topical post-laser application of human adipocyte-derived mesenchymal stem cell media combined with niacinamide significantly improved wrinkle index, melanin index, patient satisfaction, and investigator esthetic improvement scores compared to vehicle cream in patients with aging skin.

    Journal of Cosmetic Dermatology, 2021

  • Topical nicotinamide prevented solar-simulated UV-induced immunosuppression in healthy volunteers, and men experienced immunosuppression at solar-simulated UV doses three times lower than those required for women.

    The Journal of Investigative Dermatology, 2008

  • Topical 5% niacinamide applied twice daily for 12 weeks reduced fine lines and wrinkles, hyperpigmented spots, red blotchiness, and skin sallowness, and improved skin elasticity compared to vehicle control in 50 female white subjects with facial photoaging.

    Dermatologic Surgery, 2005

  • Topical adenosine treatment significantly increased the anagen hair growth rate and thick hair rate compared to placebo in Japanese women with female pattern hair loss over 12 months.

    The Journal of Dermatology, 2008

  • Topical application of a disodium adenosine monophosphate-based formulation reduced wrinkles and hyperpigmentation while improving hydration, barrier function, skin lifting, and epidermal turnover in female participants.

    International Journal of Molecular Sciences, 2026

  • Adenosine and cordycepin stimulate the Wnt/beta-catenin signaling pathway through adenosine receptor and PKA activation, promoting cell proliferation, migration, and growth factor secretion in cultured dermal fibroblasts.

    International Journal of Molecular Sciences, 2021

Ingredients

Water, Glycerin, Dimethicone, Cetearyl Alcohol, Theobroma Grandiflorum Seed Butter, Alcohol Denat, Cetearyl Isononanoate, Niacinamide, Glyceryl Stearate, Peg-100 Stearate, Isopropyl Palmitate, Octyldodecanol, Cyclodextrin, Hydrolyzed Lupine Protein, Pisum Sativum Extract, Adenosine, Capryloyl Salicylic Acid, Hydrolyzed Hyaluronic Acid, Hydrolyzed Linseed Extract, Pentaerythrityl Tetra-Di-T-Butyl Hydroxyhydrocinnamate, Trisodium Ethylenediamine Disuccinate, Tocopheryl Acetate, Alba Cera, Beeswax, Cire Dabeille, Orbignya Oleifera Seed Oil, Jojoba Butter, Cetearyl Glucoside, Citric Acid, Hydroxyethyl Acrylate Sodium Acryloyldimethyl Taurate Copolymer, Polysorbate 60, Potassium Cetyl Phosphate, Sorbitan Isostearate, Tocopherol, Dimethicone Polyglycerin-3 Crosspolymer, Benzyl Alcohol, Geraniol, Limonene, Chlorphenesin, Dipropylene Glycol, Phenoxyethanol, Sodium Benzoate, Parfum

Behind this fit score

Lovi calculates every fit score from the full ingredient list with brand-independent rules our dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update.

  • Nadia Kapleva, MS

    Nadia Kapleva, MS

    Co-founder, Medical Director

    Cosmetic chemist, cosmetologist, aesthetic products developer

  • Alexey Shagraev, PhD

    Alexey Shagraev, PhD

    Co-founder, CEO and CTO

    PhD in computer science, 3x US patent holder, ex-Google, ex-Yandex

  • Dr. Sofía Perea Pérez, MD, MSc

    Dr. Sofía Perea Pérez, MD, MSc

    Medical Board

    Aesthetic medicine practitioner, MSc in Longevity and Anti-Aging Medicine

  • Aishani Shah, MD

    Aishani Shah, MD

    Medical Board

    Specialist dermatologist, MBBS, MD, IFAAD

  • Asya Zubkova, MS

    Asya Zubkova, MS

    Medical Board

    Cosmetic chemist, SCS, IFSCC member

  • Hanna Kurets, MD

    Hanna Kurets, MD

    Medical Board, Medical Advisor

    Dermatology MD

  • Elina Nazarenko, MD

    Elina Nazarenko, MD

    Medical Board

    Dermatology and diagnostic consultant

  • Victoria Derkova, MS

    Victoria Derkova, MS

    Medical Board

    Cosmetic chemist, cosmetic development technologist

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How does it fit your skin?

Scan your face, then any product: Lovi shows how well it fits you and what fits even better.

QR code: get the Lovi app
Download on theApp Store Get it onGoogle Play